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Osteoporosis International
Published in: Osteoporosis International 12/2005

01-12-2005 | Original Article

Bone mineral density reference norms for Hong Kong Chinese

Authors: H. S. Lynn, E. M. C. Lau, B. Au, P. C. Leung

Published in: Osteoporosis International | Issue 12/2005

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Abstract

The aim of this study was to establish bone mineral density (BMD) reference norms for Hong Kong Chinese using Hologic QDR 2000 and 4500 densitometers, and to estimate the prevalence of osteoporosis in the population. Altogether, 4,274 subjects (2,415 females and 1,859 males), aged 9–94 years old, were recruited using a combination of private solicitation and public advertising from schools, community centers, nursing homes, housing estates, and the general community in Hong Kong. Among females, BMD increased by 20% at the total hip and 48% at the lumbar spine between ages 10 and 20 but remained essentially constant between ages 20 and 40. Between ages 40 and 70, BMD declined by 17% at the total hip and 23% at the spine. Total hip BMD continued to drop after age 70 but little change in spine BMD was observed. Among males, BMD increased by 45% at the total hip and 77% at the spine between age 10 and 30. Between ages 30 and 80, total hip BMD decreased by 20%. Lumbar spine BMD decrease was milder, showing a loss of 4% between ages 30 to 50 and remaining relatively constant afterwards. The prevalence of osteoporosis was consistently overestimated when using Hologic-supplied Caucasian cutoffs as compared with local Chinese cutoffs. The prevalence of osteoporosis among Chinese women 50 years or older was 37% and 16% at the spine and total hip, respectively, while that among Chinese men 50 years or older was 7% and 6% at the spine and total hip, respectively. Prior studies have been limited by size or restricted to women. This study represents the largest sample of Hong Kong Chinese amassed to date, provides continuous BMD reference values from ages 10 to 85 for both women and men, and yields more reliable estimates of the prevalence of osteoporosis for the population.
Literature
1.
Lau EMC (1997) The epidemiology of osteoporosis in Asia. In: Lau EMC (ed) Osteoporosis in Asia: Crossing the frontiers. World Scientific Publishers pp 1–9
2.
Cummings SR, Black DM, Nevitt MC (1993) Bone density at various sites for prediction of hip fractures. Lancet 341:72–75
3.
Cundy T, Cornish J, Evans MC, Gamble G, Stapleton J, Reid IR (1995) Sources of interracial variation in bone mineral density. J Bone Miner Res 10:368–373
4.
Russell-Aulet M, Wang J, Thornston JC, Cott EW, Pierson RN Jr (1993) Bone mineral density and mass in a cross-sectional study of white and Asian women. J Bone Miner Res 8:575–582
5.
Tobias JH, Cook DG, Chambers TJ, Dalzell N (1994) A comparison of bone mineral density between Caucasian, Asian and Afro-Caribbean women. Clin Sci 87:587–591
6.
Ho S, Lau EMC, Woo J, Sham A, Chan KM, Lee S, Leung PC (1999) The prevalence of osteoporosis in the Hong Kong Chinese female population. Maturitas 32:171–178
7.
Liao EY, Wu XP, Deng XG, Huang G, Zhu XP, Long ZF, Wang WB, Tang WL, Zhang H (2002) Age-related bone mineral density, accumulated bone loss rate and prevalence of osteoporosis at multiple skeletal sites in Chinese women. Osteoporos Int 13(8):669–676
8.
Woo J, Li M, Lau E (2001) Population bone mineral density measurements for Chinese women and men in Hong Kong. Osteoporos Int 12:289–295
9.
Stone CJ (1985) Additive regression and other nonparametric methods. Ann Stat 13:689–705
10.
Eubank RL (1988) Spline smoothing and nonparametric regression. Dekker, New York
11.
Wahba G (1983) Bayesian confidence intervals for the cross validated smoothing spline. J R Stat Soc Ser B 45:133–150
12.
WHO study group (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series 843. WHO, Geneva
13.
Tsai SC, Kao CH, Wang SJ, Chang Lai SP, Yen RF, Chieng PU (1997) Normal data for lumbar spine bone mineral content in healthy Chinese men. Calcif Tissue Int 61:114–116
14.
Liao EY, Wu XP, Luo XH, Zhang H, Dai RC, Huang G, Wang WB (2003) Establishment and evaluation of bone mineral density reference databases appropriate for diagnosis and evaluation of osteoporosis in Chinese women. J Bone Miner Metab 21(3):184–192
15.
Xiaoge D, Eryuan L, Xianping W, Zhiguang Z, Gan H, Zaijing J, Xiaoli P, Hongzhuan T, Hanwen W (2000) Bone mineral density differences at the femoral neck and Ward’s triangle: a comparison study on the reference data between Chinese and Caucasian women. Calcif Tissue Int 67(3):195–198
16.
Bachrach LK, Hastie T, Wang MC, Narasimhan B, Marcus R (1999) Bone mineral acquisition in healthy Asian, Hispanic, Black, and Caucasian youth: a longitudinal study. J Clin Endocrinol Metab 84:4702–4712
17.
Kessenich CR, Rosen CJ (1996) The pathophysiology of osteoporosis. In: Osteoporosis: Diagnosis and Therapeutic Principles. CJ Rosen (ed) Humana, Totowa, NJ, USA, pp 47-63
18.
Rosenthal DI, Mayo-Smith W, Hayes CW et al (1989) Age and bone mass in premenopausal women. J Bone Miner Res 4:533–538
19.
Hannan MT, Felson DT, Anderson JJ (1992) Bone mineral density in elderly men and women: results from the Framingham Osteoporosis Study. J Bone Miner Res 7:547–553
20.
Meier DE, Orwoll ES, Jones JM (1984) Marked disparity between trabecular and cortical bone loss with age in healthy men: measurement by vertebral computed tomography and radial photon absorptiometry. Ann Intern Med 101:605–612
21.
Mazess RB, Barden HS, Drinka PJ, Baumens SF, Orwoll ES, Bell NH (1990) Influence of age and body weight on spine and femur bone density in US white men. J Bone Miner Res 5:645–652
22.
Tobin JD, Fox KM, Cejku ML (1993) Bone density changes in normal men: a 4–19 year longitudinal study. J Bone Miner Res 8:102
23.
Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA (1994) Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. Br Med J 309:691–695
24.
Yoshimura N, Kinoshita H, Danjoh S, Takijiri T, Morioka S, Kasamatsu T, Sakata K, Hashimoto T (2002) Bone loss at the lumbar spine and the proximal femur in a rural Japanese community, 1990–2000: the Miyama study. Osteoporos Int 13(10):803–808
25.
Gurlek A, Bayraktar M, Ariyurek M (2000) Inappropriate reference range for peak bone mineral density in dual-energy X-ray absorptiometry: implications for the interpretation of T-scores. Osteoporos Int 11(9):809–813
26.
Tenenhouse A, Joseph L, Kreiger N, Poliquin S, Murray TM, Blondeau L, Berger C, Hanley DA, Prior JC, CaMos Research Group (2000) Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int 11(10):897–904
27.
Looker A, Orwoll E, Johnston C, Lindsay R, Wahner H, Dunn W, Calvo M, Harris T, Heyse S (1997) Prevalence of low femoral bone density in older US Adults from NHANES III. J Bone Miner Res 12(11):1761–1768
28.
Carter DR, Bouxsein ML, Marcus R (1992) New approaches for interpreting projected bone densitometry. J Bone Miner Res 7:137–145
29.
Cummings SR, Marcus R, Palermo L, Ensrud KE, Genant HK (1994) Does estimating volumetric bone density of femoral neck improve the prediction of hip fracture? A prospective study. J Bone Miner Res 9:1429–1432
30.
Lau EMC, Lynn H, Woo J, Melton LJ 3rd (2003) Areal and volumetric bone density in Hong Kong Chinese: a comparison with Caucasians living in the United States. Osteoporos Int 14:583–588
31.
Lau EM, Lee JK, Suriwongpaisal P, Saw SM, Das De S, Khir A, Sambrook P (2001) The incidence of hip fracture in four Asian countries: the Asian Osteoporosis Study (AOS). Osteoporos Int 12(3):239–243
32.
Chie WC, Yang RS, Liu JP, Tsai KS (2004) High incidence rate of hip fracture in Taiwan: estimated from a nationwide health insurance database. Osteoporos Int 15(12):998–1002
33.
Ling X, Cummings SR, Mingwei Q, Xihe Z, Xioashu C, Nevitt M, Stone K (2000) Vertebral fractures in Beijing, China: the Beijing Osteoporosis Project. J Bone Miner Res 15(10):2019–2025
Metadata
Title
Bone mineral density reference norms for Hong Kong Chinese
Authors
H. S. Lynn
E. M. C. Lau
B. Au
P. C. Leung
Publication date
01-12-2005
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 12/2005
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-005-1899-z

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