Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Osteoporosis International
Published in: Osteoporosis International 3/2006

01-03-2006 | Original Article

Increased bone fracture prevalence in postmenopausal women suffering from pollen-allergy

Authors: Viktoria Ferencz, Szilvia Meszaros, Emoke Csupor, Edit Toth, Katalin Bors, Andras Falus, Csaba Horvath

Published in: Osteoporosis International | Issue 3/2006

Login to get access

Abstract

Introduction

Our aim was to investigate whether pollen-allergy can affect bone mass and fractures in postmenopausal women.

Methods

A total of 125 postmenopausal pollen-allergic women (mean age: 61.26 yr) were split into four groups: (1) treated with neither H1 histamine receptor (H1R) antagonist nor inhaled corticosteroid (n=43); (2) treated only with H1R antagonist (n=53); (3) treated with both H1R antagonist and inhaled corticosteroid (n=17); (4) treated with only inhaled corticosteroid (n=12). Treatment, in the appropriate groups, had occurred for at least 5 years, seasonally. One-hundred non-allergic postmenopausal subjects matched for age, body mass index (BMI), and age at menopause served as controls.

Results

Overweight and obesity (25 kg/m2≤BMI) were common among the allergic women (76%). Allergic patients without treatment had a slightly lower bone density than their non-allergic counterparts. The rate (34.9%) of prevalent low-energy fractures (distal forearm, hip, and clinical vertebral fractures) in untreated allergic patients was almost triple that observed in non-allergic women (13%, chi2 p=0.003). Bone fracture occurred more often in H1R-only treated patients (30.19%) than in controls (chi2 p=0.01); however, clinical vertebral or hip fractures developed neither in those treated only with H1R antagonist nor in those who received both H1R antagonist and inhaled corticosteroid. Bone fractures were more frequent among patients with inhaled steroid treatment than among patients with a combined treatment of inhaled steroid and antihistamine (50 versus 29.4%). BMI predicted prevalent fractures at 1.278 (95% CI: 1.047–1.559, p=0.016) for a 1 kg/m2 increase among untreated allergic patients.

Conclusion

In conclusion, we found a high prevalence of low-energy fractures among pollen-allergic postmenopausal women which was associated with obesity. It is possible that the H1R antagonists compensate for both the negative effect of pollen-allergy and the adverse effect of inhaled corticosteroid treatment on bone fracture risk.
Literature
1.
McKenna MJ, Frame B (1985) The mast cell and bone. Clin Ortop 200:226–233PubMed
2.
Feik SA, Storey E (1979) Low-calcium/high phosphorus rickets in rats. Mast cell changes. Pathology 11:641–652PubMedCrossRef
3.
de Gennes C, Kuntz D, de Vernejoul MC (1992) Bone mastocytosis. A report of nine cases with a bone histomorphometric study. Clin Orthop 279:281–291
4.
Dobigny C, Saffar JL (1997) H1 and H2 histamine receptors modulate osteoclastic resorption by different pathways: evidence obtained by using receptor antagonists in a rat synchronized resorption model. J Cell Physiol 173:10–18PubMedCrossRef
5.
Nakamura M, Kuroda H, Narita K, Endo Y (1996) Parathyroid hormone induces a rapid increase in the number of active osteoclasts by releasing histamine from mast cells. Life Sci 58:1861–1868PubMedCrossRef
6.
Deyama Y, Kikuiri T, Ohnishi G, Feng YG, Takeyama S, Hatta M, Yoshimura Y, Suzuki K (2002) Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-kappaB ligand by osteoblasts. Biochem Biophys Res Commun 298:240–246PubMedCrossRef
7.
Klein I, Lehotay DC, Watson CG, Rogerson B, Levey GS (1981) Human parathyroid adenoma adenylate cyclase: stimulation by histamine that is blocked by cimetidine. Metabolism 30:635–637PubMedCrossRef
8.
Brumsen C, Papapoulos SE, Lentjes EG, Kluin PM, Hamdy NA (2002) A potential role for the mast cell in the pathogenesis of idiopathic osteoporosis in men. Bone 31:556–561PubMedCrossRef
9.
Fitzpatrick LA, Buzas E, Gagne TJ, Nagy A, Horvath C, Ferencz V, Mester A, Kari B, Ruan M, Falus A, Barsony J (2003) Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss. Proc Natl Acad Sci USA 100:6027–6032PubMedCrossRef
10.
Lippert U, Kruger–Krasagakes S, Moller A, Kiessling U, Czarnetzki BM (1995) Pharmacological modulation of IL-6 and IL-8 secretion by the H1-antagonist decarboethoxy-loratadine and dexamethasone by human mast and basophilic cell lines. Exp Dermatol 4:272–276PubMedCrossRef
11.
Vannier E, Dinarello CA (1994) Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. J Biol Chem 269:9952–9956PubMed
12.
Rasmussen LA, Nielsen HJ, Sorensen S, Sorensen C, Rasmussen R, Sorensen S, Moesgaard F, Larsen J (1995) Ranitidine reduces postoperative interleukin-6 induced C-reactive protein synthesis. J Am Coll Surg 181:138–144PubMed
13.
Rico H, Gomez M, Revilla M. Gonzalez-Riola J, Seco C, Hernandez ER, Villa LF, Gervas JJ (1999) Effects of promethazine on bone mass and on bone remodeling in ovariectomized rats: A morphometric, densitometric, and histomorphometric experimental study. Calcif Tissue Int 65:272–275PubMedCrossRef
14.
Lesclous P, Guez D, Saffar JL (2002) Short-term prevention of osteoclastic resorption and osteopenia in ovariectomized rats treated with the H2 receptor antagonist cimetidine. Bone 30:131–136PubMedCrossRef
15.
Stechschulte DJ, Sharma R, Dileepan KN, Simpson KM, Aggrawal N, Clancy J Jr, Jilka RL (1987) Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57Bl/6J mice. J Cell Physiol 132:565–570CrossRefPubMed
16.
Lippert U, Moller A, Welker P, Artuc M, Henz BM (2000) Inhibition of cytokine secretion from human leukemic mast cells and basophils by H1- and H2-receptor antagonists. Exp Dermatol 9:118–124CrossRefPubMed
17.
18.
19.
Osteoporosis Task Force (2001) American association of clinical endocrinologists. 2001 medical guidelines for clinical practice for the prevention and management of postmenopausal osteoporosis. Endocr Pract 7:293–312
20.
McCloskey EV, Spector TD, Eyres KS, Fern ED, O’Rourke N, Vasikaran S, Kanis JA. (1993) The assessment of vertebral deformity: a method for use in population studies and clinical trials. Osteoporos Int 3:138–147CrossRefPubMed
21.
Tangsinmankong N, Bahna SL, Good RA (1999) Osteoporosis for the allergist. Ann Allergy Asthma Immunol 82:5–12PubMedCrossRef
22.
Langhammer A, Norjavaara E, de Verdier MG, Johnsen R, Bjermer L (2004) Use of inhaled corticosteroids and bone mineral density in a population based study: the Nord-Trondelag Health Study (the HUNT Study). Pharmacoepidemiol Drug Saf 13:569–579CrossRefPubMed
23.
Fujita K, Kasayama S, Hashimoto J, Nagasaka Y, Nakano N, Morimoto Y, Barnes PJ, Miyatake A (2001) Inhaled corticosteroids reduce bone mineral density in early postmenopausal but not premenopausal asthmatic women. J Bone Miner Res 16:782–787PubMedCrossRef
24.
Vestergaard P, Rejnmark L, Mosekilde L (2005) Fracture risk associated with systemic and topical corticosteroids. J Intern Med 257:374–384PubMedCrossRef
25.
Tyan ML (1993) Effect of promethazine on lumbar vertebral bone mass in postmenopausal women. J Intern Med 234:143–148PubMedCrossRef
26.
van Lenthe GH, van den Bergh JP, Hermus AR, Huiskes R (2001) The prospects of estimating trabecular bone tissue properties from the combination of ultrasound, dual-energy X-ray absorptiometry, microcomputed tomography, and microfinite element analysis. J Bone Miner Res 16:550–555PubMedCrossRef
27.
Karlsson MK, Duan Y, Ahlborg H, Obrant KJ, Johnell O, Seeman E (2001) Age, gender, and fragility fractures are associated with differences in quantitative ultrasound independent of bone mineral density. Bone 28:118–122CrossRefPubMed
28.
Bauer DC, Gluer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, Black DM, for the study of osteoporotic fractures research group (1997) Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women: a prospective study. Arch Intern Med 157:629–634CrossRefPubMed
29.
Njeh CF, Fuerst T, Diessel E, Genant HK (2001) Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporos Int 12:1–15PubMed
30.
Hernandez JL, Marin F, Gonzalez-Macias J, Diez-Perez A, Vila J, Gimenez S, Galan B, Arenas MS, Suarez F, Gayola L, Guillen G, Sagredo T, Belenguer R, Moron A, Arriaza E, ECOSAP study investigators (2004) Discriminative capacity of calcaneal quantitative ultrasound and of osteoporosis and fracture risk factors in postmenopausal women with osteoporotic fractures. Calcif Tissue Int 74:357–365CrossRefPubMed
31.
Drozdzowska B, Pluskiewicz W (2002) The ability of quantitative ultrasound at the calcaneus to identify postmenopausal women with different types of nontraumatic fractures. Ultrasound Med Biol 28:1491–1497CrossRefPubMed
32.
Cepollaro C, Gonnelli S, Rottoli P, Montagnani A, Caffarelli C, Bruni D, Nikiforakis N, Fossi A, Rossi S, Nuti R (2005) Bone ultrasonography in glucocorticoid-induced osteoporosis. Osteoporos Int 16:743–748CrossRefPubMed
33.
Hans D, Dargent-Molina P, Schott AM, Sebert JL, Cormier C, Kotzki PO, Delmas PD, Pouilles JM, Breart G, Meunier PJ, for the EPIDOS prospective study group (1996) Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet 348:511–514CrossRefPubMed
34.
Joakimsen RM, Fonnebo V, Magnus JH, Tollan A, Sogaard AJ (1998) The Tromso Study: body height, body mass index and fractures. Osteoporos Int 8:436–442CrossRefPubMed
35.
Broussard DL, Magnus JH (2004) Risk assessment and screening for low bone mineral density in a multi-ethnic population of women and men: does one approach fit all? Osteoporos Int 15:349–360CrossRefPubMed
36.
Akerman MJ, Calacanis CM, Madsen MK (2004) Relationship between asthma severity and obesity. J Asthma 41:521–526PubMedCrossRef
37.
Nystad W, Meyer HE, Nafstad P, Tverdal A, Engeland A (2004) Body mass index in relation to adult asthma among 135,000 Norwegian men and women. Am J Epidemiol 160:969–976CrossRefPubMed
38.
Mai XM, Bottcher MF, Leijon I (2004) Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 15:523–530CrossRefPubMed
39.
Metadata
Title
Increased bone fracture prevalence in postmenopausal women suffering from pollen-allergy
Authors
Viktoria Ferencz
Szilvia Meszaros
Emoke Csupor
Edit Toth
Katalin Bors
Andras Falus
Csaba Horvath
Publication date
01-03-2006
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 3/2006
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-005-0011-z

Other articles of this Issue 3/2006

Osteoporosis International 3/2006 Go to the issue

Original Article

Racial variations in antiresorptive medication use: results from the 2000 Medical Expenditure Panel Survey (MEPS)

Original Article

Intensity of exercise is associated with bone density change in premenopausal women

Original Article

The long-term predictive value of bone mineral density measurements for fracture risk is independent of the site of measurement and the age at diagnosis: results from the Prospective Epidemiological Risk Factors study

Original Article

Changes in bone mass and bone turnover following tibial shaft fracture

Original Article

Use of dental panoramic radiographs in identifying younger postmenopausal women with osteoporosis

Original Article

Methodological issues in the identification of hip fractures using routine hospital data: a database study