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Published in: International Urogynecology Journal 8/2020

01-08-2020 | Cystectomy | Original Article

Total laparoscopic bladder resection in the management of deep endometriosis: “take it or leave it.” Radicality versus persistence

Authors: Marcello Ceccaroni, Roberto Clarizia, Matteo Ceccarello, Paola De Mitri, Giovanni Roviglione, Daniele Mautone, Giuseppe Caleffi, Alberto Molinari, Giacomo Ruffo, Stefano Cavalleri

Published in: International Urogynecology Journal | Issue 8/2020

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Abstract

Background

Bladder endometriosis (BE) is the most common external site of deep-infiltrating endometriosis (DIE) affecting the urinary tract. Frequently associated with other DIE lesions, it can be strongly related to a ventral spread of adenomyosis. Possible symptoms are urinary frequency, tenesmus and hematuria, and they are frequently related to DIE of the posterior and lateral compartment. Hormonal therapy can be used in non-symptomatic patients; conversely, in other cases surgical treatment is the management of choice.

Methods

Retrospective cohort study of a series of consecutive patients treated between September 2004 and December 2017 in a tertiary care referral center. Only full-thickness detrusor involvement was considered as BE. All patients underwent laparoscopic bladder resection with concomitant radical excision of DIE.

Results

BE was found in 264 patients and was associated with simultaneous bowel DIE requiring bowel resection in 140 patients (53%). Twenty-five patients (9.5%) had associated obstructive ureteral signs requiring ureteroneocystostomy. Mean hospital stay and time of catheter removal were 9.7 and 9.1 days, respectively. Postoperative major complications (< 28 days) were observed in 19 patients (7.2%). Follow-up was performed at 1, 6 and 12 months after surgery, with a 2.3% recurrence rate observed.

Conclusions

Laparoscopic partial cystectomy for BE is a feasible and safe technique, and experienced laparoscopic surgeons should consider it the gold standard treatment. Surgical eradication leads to excellent surgical outcomes in terms of reduction of symptoms and recurrence rates, considering the need to maintain an adenomyotic uterus for fertility purposes.
Literature
1.
go back to reference Koninckx PR, Ussia A, Adamyan L, Wattiez A, Donnez J. Deep endometriosis: definition, diagnosis, and treatment. Fertil Steril. 2012;98:564–71.CrossRef Koninckx PR, Ussia A, Adamyan L, Wattiez A, Donnez J. Deep endometriosis: definition, diagnosis, and treatment. Fertil Steril. 2012;98:564–71.CrossRef
2.
go back to reference Nezhat C, Falik R, McKinney S, King LP. Pathophysiology and management of urinary tract endometriosis. Nat Rev Urol. 2017;14(6):359–72.CrossRef Nezhat C, Falik R, McKinney S, King LP. Pathophysiology and management of urinary tract endometriosis. Nat Rev Urol. 2017;14(6):359–72.CrossRef
3.
go back to reference Vercellini P, Meschia M, De Giorgio O, Panazza S, Cortesi I, Crosignani PG. Bladder detrusor endometriosis: clinical and pathogenetic implications. J Urol. 1996;155:770–1.CrossRef Vercellini P, Meschia M, De Giorgio O, Panazza S, Cortesi I, Crosignani PG. Bladder detrusor endometriosis: clinical and pathogenetic implications. J Urol. 1996;155:770–1.CrossRef
4.
go back to reference Somigliana E, Vercellini P, Gattei U, Chopin N, Chiodo I, Chapron C. Bladder endometriosis: getting closer and closer to the unifying metastatic hypothesis. Fertil Steril. 2007;87:1287–90.CrossRef Somigliana E, Vercellini P, Gattei U, Chopin N, Chiodo I, Chapron C. Bladder endometriosis: getting closer and closer to the unifying metastatic hypothesis. Fertil Steril. 2007;87:1287–90.CrossRef
5.
go back to reference Donnez J, Spada F, Squifflet J, Nisolle M. Bladder endometriosis must be considered as bladder adenomyosis. Fertil Steril. 2000;74:1175–81.CrossRef Donnez J, Spada F, Squifflet J, Nisolle M. Bladder endometriosis must be considered as bladder adenomyosis. Fertil Steril. 2000;74:1175–81.CrossRef
6.
go back to reference Donnez J, Van Langendonckt A, Casanas Roux F, Van Gossum JP, Pirard C, Jadoul P, et al. Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Investig. 2002;54:52–62.CrossRef Donnez J, Van Langendonckt A, Casanas Roux F, Van Gossum JP, Pirard C, Jadoul P, et al. Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Investig. 2002;54:52–62.CrossRef
7.
go back to reference Chapron C, Chopin N, Borghese B, Foulot H, Dousset B, Vacher Lavenu MC, et al. Deeply infiltrating endometriosis: pathogenetic implications of the anatomical distribution. Hum Reprod. 2006;21:1839–45.CrossRef Chapron C, Chopin N, Borghese B, Foulot H, Dousset B, Vacher Lavenu MC, et al. Deeply infiltrating endometriosis: pathogenetic implications of the anatomical distribution. Hum Reprod. 2006;21:1839–45.CrossRef
8.
go back to reference Mettler L, Gaikwad V, Riebe B, Schollmeyer T. Bladder endometriosis: possibility of treatment by laparoscopy. JSLS. 2008;12:162–5.PubMedPubMedCentral Mettler L, Gaikwad V, Riebe B, Schollmeyer T. Bladder endometriosis: possibility of treatment by laparoscopy. JSLS. 2008;12:162–5.PubMedPubMedCentral
9.
go back to reference Villa G, Mabrouk M, Guerrini M, Mignemi G, Montanari G, Fabbri E, et al. Relationship between site and size of bladder endometriotic nodules and severity of dysuria. J Minim Invasive Gynecol. 2007;14:628–32.CrossRef Villa G, Mabrouk M, Guerrini M, Mignemi G, Montanari G, Fabbri E, et al. Relationship between site and size of bladder endometriotic nodules and severity of dysuria. J Minim Invasive Gynecol. 2007;14:628–32.CrossRef
10.
go back to reference Roberti Maggiore UL, Ferrero S, Candiani M, Somigliana E, Viganò P, Vercellini P. Bladder endometriosis: a systematic review of pathogenesis, diagnosis, treatment, impact on fertility, and risk of malignant transformation. Eur Urol. 2017;71:790–817.CrossRef Roberti Maggiore UL, Ferrero S, Candiani M, Somigliana E, Viganò P, Vercellini P. Bladder endometriosis: a systematic review of pathogenesis, diagnosis, treatment, impact on fertility, and risk of malignant transformation. Eur Urol. 2017;71:790–817.CrossRef
11.
go back to reference Vercellini P, Buggio L, Berlanda N, Barbara G, Somigliana E, Bosari S. Estrogen-progestins and progestins for the management of endometriosis. Fertil Steril. 2016;106:1552–71.CrossRef Vercellini P, Buggio L, Berlanda N, Barbara G, Somigliana E, Bosari S. Estrogen-progestins and progestins for the management of endometriosis. Fertil Steril. 2016;106:1552–71.CrossRef
12.
go back to reference Chapron C, Bourret A, Chopin N, Dousset B, Leconte M, Amsellem Ouazana D, et al. Surgery for bladder endometriosis: long-term results and concomitant management of associated posterior deep lesions. Hum Reprod. 2010;25:884–9.CrossRef Chapron C, Bourret A, Chopin N, Dousset B, Leconte M, Amsellem Ouazana D, et al. Surgery for bladder endometriosis: long-term results and concomitant management of associated posterior deep lesions. Hum Reprod. 2010;25:884–9.CrossRef
13.
go back to reference Dubuisson JB, Chapron C, Aubriot FX, Osman M, Zerbib M. Pregnancy after laparoscopic partial cystectomy for bladder endometriosis. Hum Reprod. 1994;9:730–2.CrossRef Dubuisson JB, Chapron C, Aubriot FX, Osman M, Zerbib M. Pregnancy after laparoscopic partial cystectomy for bladder endometriosis. Hum Reprod. 1994;9:730–2.CrossRef
14.
go back to reference Ceccaroni M, Pontrelli G, Scioscia M, Ruffo G, Bruni F, Minelli L. Nerve-sparing laparoscopic radical excision of deep endometriosis with rectal and parametrial resection. J Minim Invasive Gynecol. 2010;17:14–5.CrossRef Ceccaroni M, Pontrelli G, Scioscia M, Ruffo G, Bruni F, Minelli L. Nerve-sparing laparoscopic radical excision of deep endometriosis with rectal and parametrial resection. J Minim Invasive Gynecol. 2010;17:14–5.CrossRef
15.
go back to reference Ceccaroni M, Clarizia R, Bruni F, et al. Nerve-sparing laparoscopic eradication of deep endometriosis with segmental rectal and parametrial resection: the Negrar method. A single center, prospective, clinical trial. Surg Endosc. 2012;26:2029–45.CrossRef Ceccaroni M, Clarizia R, Bruni F, et al. Nerve-sparing laparoscopic eradication of deep endometriosis with segmental rectal and parametrial resection: the Negrar method. A single center, prospective, clinical trial. Surg Endosc. 2012;26:2029–45.CrossRef
16.
go back to reference Joseph J, Hitendra RH. Patel. Retroperitoneal robotic and laparoscopic surgery, Springer 2011. Joseph J, Hitendra RH. Patel. Retroperitoneal robotic and laparoscopic surgery, Springer 2011.
17.
go back to reference Testut L. Appareil urogenital, Peritoine. In: Latarget A. Traité d’anatomie humaine. 8th edn revue par, G Doin et Cie Editeurs, Paris. 1931. Testut L. Appareil urogenital, Peritoine. In: Latarget A. Traité d’anatomie humaine. 8th edn revue par, G Doin et Cie Editeurs, Paris. 1931.
18.
go back to reference Scarperi S, Pontrelli G, Campana C, Steinkasserer M, Ercoli A, Minelli L, Bergamini V, Ceccaroni M. Laparoscopic radiofrequency thermal ablation for uterine adenomyosis. JSLS. 2015;19(4). Scarperi S, Pontrelli G, Campana C, Steinkasserer M, Ercoli A, Minelli L, Bergamini V, Ceccaroni M. Laparoscopic radiofrequency thermal ablation for uterine adenomyosis. JSLS. 2015;19(4).
19.
go back to reference Ceccaroni M, Ceccarello M, Caleffi G, Clarizia R, Scarperi S, Pastorello M, Molinari A, Ruffo G, Cavalleri S. Total laparoscopic ureteroneocystostomy for ureteral endometriosis: a single-center experience of 160 consecutive patients. J Minim Invasive Gynecol, 2019. Ceccaroni M, Ceccarello M, Caleffi G, Clarizia R, Scarperi S, Pastorello M, Molinari A, Ruffo G, Cavalleri S. Total laparoscopic ureteroneocystostomy for ureteral endometriosis: a single-center experience of 160 consecutive patients. J Minim Invasive Gynecol, 2019.
20.
go back to reference Bergmark K, Avall-Lundqvist E, Dickman PW, Henningson L, Steineck G. Vaginal changes and sexuality in women with a history of cervical cancer. N Engl J Med. 1999;340:1383–9.CrossRef Bergmark K, Avall-Lundqvist E, Dickman PW, Henningson L, Steineck G. Vaginal changes and sexuality in women with a history of cervical cancer. N Engl J Med. 1999;340:1383–9.CrossRef
21.
go back to reference Diagnostic and Statistical Manual of Mental Disorders, 4th ed., American Psychiatric Association, Washington D.C. 2000. Diagnostic and Statistical Manual of Mental Disorders, 4th ed., American Psychiatric Association, Washington D.C. 2000.
22.
go back to reference The World Health Organization quality of life instruments. 1997. The World Health Organization quality of life instruments. 1997.
23.
go back to reference Ceccaroni M, Roviglione G, Spagnolo E, Casadio P, Clarizia R, Peiretti M, et al. Pelvic dysfunctions and quality of life after nerve-sparing radical hysterectomy: a multicenter comparative study. Anticancer Res. 2012;32(2):581–8.PubMed Ceccaroni M, Roviglione G, Spagnolo E, Casadio P, Clarizia R, Peiretti M, et al. Pelvic dysfunctions and quality of life after nerve-sparing radical hysterectomy: a multicenter comparative study. Anticancer Res. 2012;32(2):581–8.PubMed
24.
go back to reference American Society for Reproductive Medicine. Revised American society for reproductive medicine classification of endometriosis. 1996. American Society for Reproductive Medicine. Revised American society for reproductive medicine classification of endometriosis. 1996.
25.
go back to reference Mitropoulos D, Artibani W, Graefen M, Remzi M, Rouprêt M, Truss M, et al. Reporting and grading of complications after urologic surgical procedures: an ad hoc EAU guidelines panel assessment and recommendations. Eur Urol. 2012;61(2):341–9.CrossRef Mitropoulos D, Artibani W, Graefen M, Remzi M, Rouprêt M, Truss M, et al. Reporting and grading of complications after urologic surgical procedures: an ad hoc EAU guidelines panel assessment and recommendations. Eur Urol. 2012;61(2):341–9.CrossRef
26.
go back to reference Scioscia M, Bruni F, Ceccaroni M, Steinkasserer M, Stepniewska A, Minelli L. Distribution of endometriotic lesions in endometriosis stage IV supports the menstrual reflux theory and requires specific preoperative assessment and therapy. Acta Obstet Gynecol Scand. 2011;90:136–9.CrossRef Scioscia M, Bruni F, Ceccaroni M, Steinkasserer M, Stepniewska A, Minelli L. Distribution of endometriotic lesions in endometriosis stage IV supports the menstrual reflux theory and requires specific preoperative assessment and therapy. Acta Obstet Gynecol Scand. 2011;90:136–9.CrossRef
27.
go back to reference Maccagnano C, Pellucchi F, Rocchini L, Ghezzi M, Scattoni V, Montorsi F, et al. Diagnosis and treatment of bladder endometriosis: state of the art. Urol Int. 2012;89(3):249–58.CrossRef Maccagnano C, Pellucchi F, Rocchini L, Ghezzi M, Scattoni V, Montorsi F, et al. Diagnosis and treatment of bladder endometriosis: state of the art. Urol Int. 2012;89(3):249–58.CrossRef
28.
go back to reference Abrao MS, Dias JA Jr, Bellelis P, Podgaec S, Bautzer CR, Gromatsky C. Endometriosis of the ureter and bladder are not associated diseases. Fertil Steril. 2009;91(5):1662–7.CrossRef Abrao MS, Dias JA Jr, Bellelis P, Podgaec S, Bautzer CR, Gromatsky C. Endometriosis of the ureter and bladder are not associated diseases. Fertil Steril. 2009;91(5):1662–7.CrossRef
29.
go back to reference Vercellini P, Pisacreta A, Pesole A, Vincentini S, Stellato G, Crosignan PG. Is ureteral endometriosis an asymmetric disease? BJOG. 2000;4:559–61.CrossRef Vercellini P, Pisacreta A, Pesole A, Vincentini S, Stellato G, Crosignan PG. Is ureteral endometriosis an asymmetric disease? BJOG. 2000;4:559–61.CrossRef
30.
go back to reference Schonman R, Dotan Z, Weintraub AY, Bibi G, Eisenberg VH, Seidman DS, et al. Deep endometriosis inflicting the bladder: long-term outcomes of surgical management. Arch Gynecol Obstet. 2013;288(6):1323–8.CrossRef Schonman R, Dotan Z, Weintraub AY, Bibi G, Eisenberg VH, Seidman DS, et al. Deep endometriosis inflicting the bladder: long-term outcomes of surgical management. Arch Gynecol Obstet. 2013;288(6):1323–8.CrossRef
31.
go back to reference Kovoor E, Nassif J, Miranda-Mendoza I, Wattiez A. Endometriosis of bladder: outcomes after laparoscopic surgery. J Minim Invasive Gynecol. 2010;17(5):600–4.CrossRef Kovoor E, Nassif J, Miranda-Mendoza I, Wattiez A. Endometriosis of bladder: outcomes after laparoscopic surgery. J Minim Invasive Gynecol. 2010;17(5):600–4.CrossRef
32.
go back to reference Sánchez Merino JM, Guillán Maquieira C, García Alonso J. The treatment of bladder endometriosis. Arch Esp Urol. 2005;58:189–94.PubMed Sánchez Merino JM, Guillán Maquieira C, García Alonso J. The treatment of bladder endometriosis. Arch Esp Urol. 2005;58:189–94.PubMed
33.
go back to reference Vignali M, Bianchi S, Candiani M, Spadaccini G, Oggioni G, Busacca M. Surgical treatment of deep endometriosis and risk of recurrence. J Minim Invasive Gynecol. 2005;12:508–13 1990; 13: 227-236.CrossRef Vignali M, Bianchi S, Candiani M, Spadaccini G, Oggioni G, Busacca M. Surgical treatment of deep endometriosis and risk of recurrence. J Minim Invasive Gynecol. 2005;12:508–13 1990; 13: 227-236.CrossRef
Metadata
Title
Total laparoscopic bladder resection in the management of deep endometriosis: “take it or leave it.” Radicality versus persistence
Authors
Marcello Ceccaroni
Roberto Clarizia
Matteo Ceccarello
Paola De Mitri
Giovanni Roviglione
Daniele Mautone
Giuseppe Caleffi
Alberto Molinari
Giacomo Ruffo
Stefano Cavalleri
Publication date
01-08-2020
Publisher
Springer International Publishing
Published in
International Urogynecology Journal / Issue 8/2020
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-019-04107-4

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