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International Urogynecology Journal
Published in: International Urogynecology Journal 7/2018

01-07-2018 | Original Article

Comparison of inflammatory urine markers in patients with interstitial cystitis and overactive bladder

Authors: Akira Furuta, Tokunori Yamamoto, Yasuyuki Suzuki, Momokazu Gotoh, Shin Egawa, Naoki Yoshimura

Published in: International Urogynecology Journal | Issue 7/2018

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Abstract

Introduction and hypothesis

Chronic inflammatory conditions seem to be a shared characteristic in patients with interstitial cystitis (IC) and overactive bladder (OAB). Thus, we measured 40 inflammatory urine markers in IC patients with or without Hunner’s lesions (HIC and NHIC respectively) and OAB patients.

Methods

Urine was collected from consecutive HIC patients, NHIC patients, and age and gender-matched OAB patients with no history of IC, recurrent urinary tract infection or bladder cancer. The diagnosis of IC was based on the Asian IC guideline criteria. A representative 40 inflammatory growth factors, cytokines, and chemokines in urine were measured using a MILLIPLEX immunoassay kit. Statistical differences in these markers among the groups were determined by nonparametric ANOVA followed by multiple comparison test. The diagnostic efficiency of these markers was measured using receiver operating characteristic analysis.

Results

Vascular endothelial growth factor (VEGF), interleukin-1α (IL-1α), IL-6, and chemokines including CCL2, CCL5, CXCL1, CXCL8, and CXCL10 were significantly increased in HIC (n = 30) and NHIC (n = 30) patients compared with OAB (n = 28) patients. The significant increases in CXCL8 and CXCL10 were also found in HIC patients compared with NHIC patients. However, there were no significant differences in the other urine markers among the groups. Area under the curves for VEGF, CXCL10, CXCL8, IL-1α, CCL5, CCL2, IL-6, and CXCL1 to detect IC in these patients were 0.87, 0.86, 0.81, 0.80, 0.80, 0.71, 0.66, and 0.50 respectively.

Conclusions

The increases in angiogenesis-associated proteins such as VEGF and CXCL10 may be pathophysiologically important for the development of IC.
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Metadata
Title
Comparison of inflammatory urine markers in patients with interstitial cystitis and overactive bladder
Authors
Akira Furuta
Tokunori Yamamoto
Yasuyuki Suzuki
Momokazu Gotoh
Shin Egawa
Naoki Yoshimura
Publication date
01-07-2018
Publisher
Springer London
Published in
International Urogynecology Journal / Issue 7/2018
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-017-3547-5

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Commentary on: Comparison of inflammatory urine markers in patients with interstitial cystitis and overactive bladder