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Published in:

01-02-2011 | Original Article

Intrasphincteric injections of autologous muscular cells in women with refractory stress urinary incontinence: a prospective study

Authors: Philippe Sèbe, Christelle Doucet, Jean-Nicolas Cornu, Calin Ciofu, Pierre Costa, Sixtina Gil Diez de Medina, Christian Pinset, Francois Haab

Published in: International Urogynecology Journal | Issue 2/2011

Abstract

Introduction and hypothesis

Cell therapy for stress urinary incontinence (SUI) management has been experienced with encouraging results.

Methods

We conducted an open prospective study on 12 women presenting severe SUI with fixed urethra, after previous failed surgical management. Patients underwent intrasphincteric injections of autologous progenitor muscular cells isolated from a biopsy of deltoid muscle. Primary endpoint focused on safety (measurement of Q _max variation after 3 months). Secondary endpoints assessed side effects and efficacy.

Results

No variation was diagnosed on Q _max measurements. Efficacy data show that three of 12 patients are dry at 12 months, seven other patients are improved on pad test but not on voiding diary, and two patients were slightly worsened by the procedure. Quality of life was improved in half of patients.

Conclusions

Cell therapy for severe multioperated cases of SUI is a mini-invasive, feasible, and safe procedure that can improve urinary condition in as a second line therapy.

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Title: Intrasphincteric injections of autologous muscular cells in women with refractory stress urinary incontinence: a prospective study
Authors: Philippe Sèbe
Christelle Doucet
Jean-Nicolas Cornu
Calin Ciofu
Pierre Costa
Sixtina Gil Diez de Medina
Christian Pinset
Francois Haab
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 2/2011
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1255-5

At a glance: The STEP trials

Springer Medicine

Intrasphincteric injections of autologous muscular cells in women with refractory stress urinary incontinence: a prospective study

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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