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01-02-2009 | Original Article

Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse

Authors: Peter Takacs, Mehdi Nassiri, Anita Viciana, Keith Candiotti, Alessia Fornoni, Carlos A. Medina

Published in: International Urogynecology Journal | Issue 2/2009

Abstract

The aim of this study was to compare fibulin-5 expression in women with and without anterior vaginal wall prolapse. Vaginal tissues were sampled in a standardized fashion from women with (n = 12) or without (n = 10) anterior vaginal wall prolapse. Quantitative real-time polymerase chain reaction was performed to measure mRNA levels of fibulin-5 (FIB-5). FIB-5 protein expression was assessed by immunohistochemistry. There were no significant differences in demographic data between the two groups. FIB-5 mRNA expression was significantly decreased in women with anterior vaginal wall prolapse compared to women without prolapse [(FIB-5 mean ± SD mRNA expression in relative units) 0.01 ± 0.01 vs. 0.09 ± 0.14, P = 0.04]. Fibulin-5 staining intensity was diminished in women with prolapse compared to women without prolapse [intensity score, median (range), 1 (1–2) vs. 3 (2–3), P = 0.04]. Fibulin-5 expression is decreased in vaginal biopsies from women with prolapse. Changes in fibulin expression may play a role in the development of pelvic organ prolapse.

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Title: Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse
Authors: Peter Takacs
Mehdi Nassiri
Anita Viciana
Keith Candiotti
Alessia Fornoni
Carlos A. Medina
Publication date: 01-02-2009
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 2/2009
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-008-0757-x

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Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse

Abstract

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Abstract

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