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01-01-2007 | Original Article

Changes in the extracellular matrix in the anterior vagina of women with or without prolapse

Authors: Sheng-Yen Lin, Yi-Torng Tee, Soo-Cheen Ng, Han Chang, PinPin Lin, Gin-Den Chen

Published in: International Urogynecology Journal | Issue 1/2007

Abstract

To investigate the changes in the connective tissues located in the upper portion of the anterior vaginal wall, which are associated with anterior vaginal wall prolapse, 23 women with anterior vaginal wall prolapse were included in the study group and 15 women with normal genital support served as control group. The anterior vaginal wall tissue samples were obtained for immunohistochemical staining of collagen (type I, III, IV, V, VI), elastin, and glycoproteins from the extracellular matrix (fibronectin, vitronectin, laminin). The number of capillaries per arteriole and mitochondria numbers per smooth muscle cell were evaluated for demonstrating whether the anatomical prolapse affect on blood supply to these tissues. Collagen III was significantly less in the anterior vaginal wall of patients with anterior vaginal wall prolapse. Quantitative immunoreactivity of collagen I and III had significant positive correlations with ageing.

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Title: Changes in the extracellular matrix in the anterior vagina of women with or without prolapse
Authors: Sheng-Yen Lin
Yi-Torng Tee
Soo-Cheen Ng
Han Chang
PinPin Lin
Gin-Den Chen
Publication date: 01-01-2007
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 1/2007
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-006-0090-1

ACC 2024 Congress

Springer Medicine

Changes in the extracellular matrix in the anterior vagina of women with or without prolapse

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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