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Knee Surgery, Sports Traumatology, Arthroscopy
Published in: Knee Surgery, Sports Traumatology, Arthroscopy 6/2019

Open Access 01-06-2019 | Osteoarthrosis | KNEE

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

Authors: Norman Waugh, Hema Mistry, Andrew Metcalfe, Emma Loveman, Jill Colquitt, Pamela Royle, Nick A. Smith, Tim Spalding

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 6/2019

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Abstract

Purpose

To assess the clinical effectiveness and cost-effectiveness of meniscal allograft transplantation (MAT) after meniscal injury and subsequent meniscectomy.

Methods

Systematic review of clinical effectiveness and cost-effectiveness analysis.

Results

There is considerable evidence from observational studies, of improvement in symptoms after meniscal allograft transplantation, but we found only one small pilot trial with a randomised comparison with a control group that received non-surgical care. MAT has not yet been proven to be chondroprotective. Cost-effectiveness analysis is not possible due to a lack of data on the effectiveness of MAT compared to non-surgical care.

Conclusion

The benefits of MAT include symptomatic relief and restoration of at least some previous activities, which will be reflected in utility values and hence in quality-adjusted life years, and in the longer term, prevention or delay of osteoarthritis, and avoidance or postponement of some knee replacements, with resulting savings. It is likely to be cost-effective, but this cannot be proven on the basis of present evidence.

Level of evidence

IV.
Appendix
Available only for authorised users
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Metadata
Title
Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness
Authors
Norman Waugh
Hema Mistry
Andrew Metcalfe
Emma Loveman
Jill Colquitt
Pamela Royle
Nick A. Smith
Tim Spalding
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 6/2019
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-019-05504-4

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