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Knee Surgery, Sports Traumatology, Arthroscopy
Published in: Knee Surgery, Sports Traumatology, Arthroscopy 6/2019

Open Access 01-06-2019 | KNEE

Autograft or allograft for reconstruction of anterior cruciate ligament: a health economics perspective

Authors: Hema Mistry, Andrew Metcalfe, Jill Colquitt, Emma Loveman, Nick A. Smith, Pamela Royle, Norman Waugh

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 6/2019

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Abstract

Purpose

To assess the clinical and cost-effectiveness of allografts versus autografts in the reconstruction of anterior cruciate ligaments.

Methods

Systematic review of comparative clinical effectiveness and cost-effectiveness analysis.

Results

Both autograft and allograft reconstruction are highly effective. Recent studies show little difference in failure rates between autografts and allografts (about 6% and 7%, respectively). In cost-effectiveness analysis, the price differential is the main factor, making autografts the first choice. However, there will be situations, particularly in revision ACL reconstruction, where an allograft may be preferred, or may be the only reasonable option available.

Conclusion

In ACL reconstruction, clinical results with autografts are as good as or slightly better than with allografts. Allografts cost more, indicating that autografts are more cost-effective and should usually be first choice.

Level of evidence

II.
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Metadata
Title
Autograft or allograft for reconstruction of anterior cruciate ligament: a health economics perspective
Authors
Hema Mistry
Andrew Metcalfe
Jill Colquitt
Emma Loveman
Nick A. Smith
Pamela Royle
Norman Waugh
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 6/2019
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-019-05436-z

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