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Knee Surgery, Sports Traumatology, Arthroscopy

Published in:

01-01-2009 | Shoulder

Release of growth factors after arthroscopic acromioplasty

Authors: Pietro Randelli, Fabrizio Margheritini, Paolo Cabitza, Giada Dogliotti, Massimiliano M. Corsi

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 1/2009

Abstract

It has recently been postulated that a variety of growth factors may be released from cancellous bone after an acromioplasty. The aim of this study was to demonstrate the presence of growth factors in the subacromial space after acromioplasty. Between October 2006 and March 2007, 23 patients underwent arthroscopic acromioplasty. A sample of at least 3 ml of fluid from the shoulder was obtained 15 min after the end of the procedure. At the same time another sample of 3 ml of the patient’s venous blood was obtained as a control. The concentrations of growth factors in the fluids collected were determined using enzyme-linked immunosorbent assay (ELISA). The growth factors assayed were platelet-derived growth factor-AB (PDGF-AB), basic fibroblast growth factor basic (bFGF) and transforming growth factor beta 1 (TGF-β1). The concentrations of TGF-β1 (p = 0.0001), PDGF-AB (p = 0.02), and bFGF (p < 0.0001) were significantly higher in the fluid from the subacromial space than in the blood sample. There are high concentrations of several growth factors in the subacromial space after acromioplasty.

Adolfsson L, Lysholm J (1993) Results of arthroscopic acromioplasty related to rotator cuff lesions. Int Orthop 17:228–231PubMedCrossRef

Altchek DW, Warren RF, Wickiewicz TL et al (1990) Arthroscopic acromioplasty: techniques and results. J Bone Joint Surg 72A:1198–1207

Alvarez RH, Kantarjian HM, Cortes JE (2006) Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 81:1241–1257PubMedCrossRef

Anitua E, Andia I, Sanchez M et al (2005) Autologous preparation rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res 23:281–286PubMedCrossRef

Bigliani L, Morrison DV, April EW (1986) The morphology of the acromion and its relationship to rotator cuff tears. Orthop Trans 10:216

Burkhart SS, Morgan CD, Kibler WB (2003) The disabled throwing shoulder: spectrum of pathology. Part II: evaluation and treatment of SLAP lesions in throwers. Arthroscopy 19:531–539PubMed

Canalis E, Centrella M, McCarthy T (1988) Effects of basic fibroblast growth factor on bone formation in vitro. J Clin Invest 81:1572–1577PubMedCrossRef

Canalis E, McCarthy TL, Centrella M (1989) Effects of platelet-derived growth factor on bone formation in vitro. J Cell Physiol 140:530–537PubMedCrossRef

Chan BP, Chan K, Maffulli N et al (1997) Effect of basic fibroblast growth factor: an in vitro study of tendon healing. Clin Orthop Rel Res 342:239–247

10.

Creaney L, Hamilton B (2008) Growth factor delivery methods in the management of sports injuries: the state of play. Br J Sports Med 42:314–320PubMedCrossRef

11.

Efthimiadou A, Asimakopoulos B, Nikolettos N et al (2006) Angiogenic effect of intramuscular administration of basic and acidic fibroblast growth factor on skeletal muscles and influence of exercise on muscle angiogenesis. Br J Sports Med 40:35–39PubMedCrossRef

12.

Ellman H (1987) Arthroscopic subacromial decompression: analysis of one- to three-year results. Arthroscopy 3:173–181PubMed

13.

Ellman H (1990) Diagnosis and treatment of incomplete rotator cuff tears. Clin Orthop Rel Res 254:64–74

14.

Esch JC, Ozerkis LR, Helgager JA et al (1988) Arthroscopic subacromial decompression: results according to the degree of rotator cuff tear. Arthroscopy 4:241–249PubMed

15.

Everts PA, Devilee RJ, Oosterbos CJ et al (2007) Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis. Knee Surg Sports Traumatol Arthrosc 15:888–894PubMedCrossRef

16.

Gartsman GM (1990) Arthroscopic acromioplasty for lesions of the rotator cuff. J Bone Joint Surg 72A:169–180

17.

Gotoh M, Hamada K, Yamakawa H et al (2001) Interleukin-1-induced subacromial synovitis and shoulder pain in rotator cuff diseases. Rheumatology 40:995–1001PubMedCrossRef

18.

Gruber P, Varga F, Fischer M et al (2002) Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, microparticles, and membranes. Clin Oral Impl Res 13:529–535CrossRef

19.

Itoi E, Tabata S (1992) Incomplete rotator cuff tears. Results of operative treatment. Clin Orthop Rel Res 284:128–135

20.

Kobayashi D, Kurosaka M, Yoshiya S et al (1997) Effect of basic fibroblast growth factor on the healing of defects in the canine anterior cruciate ligament. Knee Surg Sports Traumatol Arthrosc 5:189–194PubMedCrossRef

21.

Menetrey J, Kasemkijwattana C, Day CS et al (2000) Growth factors improve muscle healing in vivo. J Bone Joint Surg 82B:131–137CrossRef

22.

Mishra A, Pavelko T (2006) Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 34:1774–1778PubMedCrossRef

23.

Miyazono F, Okabe T, Urabe A et al (1985) A platelet factor that stimulates the proliferation of vascular endothelial cells. Biochem Biophys Res Commun 126:83–88PubMedCrossRef

24.

Molloy T, Wang Y, Murrell G (2003) The roles of growth factors in tendon and ligament healing. Sports Med 33:381–394PubMedCrossRef

25.

Neer CS 2nd (1972) Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. J Bone Joint Surg 54-A:41–50

26.

Neer CS 2nd (1983) Impingement lesions. Clin Orthop Rel Res 173:70–77

27.

Patel VR, Singh D, Calvert PT et al (1999) Arthroscopic subacromial decompression: results and factors affecting outcome. J Shoulder Elbow Surg 8:231–237PubMedCrossRef

28.

Payne LZ, Altchek DW, Craig EV et al (1997) Arthroscopic treatment of partial rotator cuff tears in young athletes: a preliminary report. Am J Sports Med 25:299–305PubMedCrossRef

29.

Raisz LG (1999) Physiology and pathophysiology of bone remodeling. Clin Chem 45:1353–1358PubMed

30.

Ryu RKN (1992) Arthroscopic subacromial decompression: a clinical review. Arthroscopy 8:141–147PubMed

31.

Sampson TG, Nisbet JK, Glick JM (1991) Precision acromioplasty in arthroscopic subacromial decompression of the shoulder. Arthroscopy 7:301–307PubMed

32.

Sanchez AR, Sheridan PJ, Kupp LI (2003) Is platelet-rich plasma the perfect enhancement factor? A current review. Int J Oral Maxillofac Implants 18:93–103PubMed

33.

Sanchez M, Anitua E, Azofra J, Andia I, Padilla S, Muljika I (2007) Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 35:245–251PubMedCrossRef

34.

Snyder SJ, Pachelli AF, Del Pizzo W et al (1991) Partial thickness rotator cuff tears: results of arthroscopic treatment. Arthroscopy 7:1–7PubMed

35.

Stephens SR, Warren RF, Payne LZ et al (1998) Arthroscopic acromioplasty: a 6- to 10-year follow-up. Arthroscopy 14:382–388PubMedCrossRef

36.

Thornton SC, Por SB, Penny R, Richter M, Shelley L, Breit SN (1991) Identification of the major fibroblast growth factors released spontaneously in inflammatory arthritis as platelet derived growth factor and tumour necrosis factor-alpha. Clin Exp Immunol 86:79–86PubMed

37.

Weber SC (1999) Arthroscopic debridement and acromioplasty versus mini-open repair in the treatment of significant partial-thickness rotator cuff tears. Arthroscopy 15:126–131PubMedCrossRef

38.

Wolf EM, Pennington WT, Agrawal V (2005) Arthroscopic side-to-side rotator cuff repair. Arthroscopy 21:881–887PubMed

39.

Wright SA, Cofield RH (1996) Management of partial-thickness rotator cuff tears. J Shoulder Elbow Surg 5:458–466PubMedCrossRef

40.

Yoshikawa Y, Abrahamsson S (2001) Dose-related cellular effects of platelet-derived growth factor-BB differ in various types of rabbit tendons in vitro. Acta Orthop Scand 72:287–292PubMedCrossRef

Title: Release of growth factors after arthroscopic acromioplasty
Authors: Pietro Randelli
Fabrizio Margheritini
Paolo Cabitza
Giada Dogliotti
Massimiliano M. Corsi
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 1/2009
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-008-0653-4

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Release of growth factors after arthroscopic acromioplasty

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