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Published in: Intensive Care Medicine 7/2020

01-07-2020 | Cardiopulmonary Resuscitation | Imaging in Intensive Care Medicine

Liquefactive necrosis of the brain

Author: Eelco F. M. Wijdicks

Published in: Intensive Care Medicine | Issue 7/2020

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Excerpt

A 63-year-old woman remained in a prolonged comatose state following anoxic–ischemic injury after cardiopulmonary resuscitation. She was cared for at home by her family for 3 years, but was readmitted with acute on chronic hypercarbic and hypoxic respiratory failure, worsening pleural effusions, and a brief episode of pulseless electrical activity not requiring chest compression. On admission repeated neurologic examinations showed no awareness, no mouthing of words with a tracheostomy in situ, spontaneous eye drifts with a quick phase of nystagmus, not tracking nor fixating on objects or persons approaching the bedside. Winces were random and brief. There was severe spasticity, extensor posturing, hyperreflexia, and contractures. Her next of kin were convinced there was improvement and emotional connection. Now, MRI showed a residual scaffold of the brain due to global atrophy and cystic encephalomalacia with preponderance in the parietal-occipital watershed regions (Fig. 1). The pathophysiology is an intensive destructive process from ischemia by hydrolytic enzymes resulting in cavitation filled with liquid fluid. Cystification of the brain due to liquefactive necrosis and mineralization is rarely longitudinally imaged and a result of frequently instituted withdrawal of support when the initial neurologic and MRI findings are very worrisome. With such extensive loss of critical brain structures involving thalamocortical and subcortical circuitry, improvement is inconceivable.
Metadata
Title
Liquefactive necrosis of the brain
Author
Eelco F. M. Wijdicks
Publication date
01-07-2020
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 7/2020
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-019-05856-y

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