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At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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Intensive Care Medicine
Appendix
Available only for authorised users
Literature
1.
Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRef
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Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, Stewart TE, Briel M, Talmor D, Mercat A, Richard JC, Carvalho CR, Brower RG (2015) Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med 372:747–755CrossRefPubMed
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Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, Protti A, Gotti M, Chiurazzi C, Carlesso E, Chiumello D, Quintel M (2016) Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med 42:1567–1575CrossRefPubMed
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de Jager P, Burgerhof JG, van Heerde M, Albers MJ, Markhorst DG, Kneyber MC (2014) Tidal volume and mortality in mechanically ventilated children: a systematic review and meta-analysis of observational studies. Crit Care Med 42:2461–2472CrossRefPubMed
Metadata
Title
High-fidelity computational simulation to refine strategies for lung-protective ventilation in paediatric acute respiratory distress syndrome
Authors
Sina Saffaran
Anup Das
Jonathan G. Hardman
Nadir Yehya
Declan G. Bates
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 7/2019
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-019-05559-4

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