A central catheter was inserted without difficulty through the left internal jugular (LIJ) vein in a 69-year-old male patient. Anteroposterior chest X-ray showed the central catheter entering from the LIJ vein and descending through the left mediastinal border (Fig. 1). A transthoracic echocardiogram (TTE) showed gross dilatation of the coronary sinus (CS) (Fig. 2). A 10-ml agitated saline bolus through the central catheter demonstrated the bubbles filling first the coronary sinus and then the right atrium through it, confirming the diagnosis of persistent left superior vena cava (PLSVC) (Video 1). Chest computed tomography (CT) corroborated this diagnosis (Fig. 3).