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Intensive Care Medicine
Published in: Intensive Care Medicine 2/2018

01-02-2018 | Letter

Is ticagrelor safe in intensive care unit patients? Focus on bradycardic events

Authors: Xavier Valette, Suzanne Goursaud, Joachim Alexandre, Maxime Leclerc, Vincent Roule, Farzin Beygui, Damien du Cheyron

Published in: Intensive Care Medicine | Issue 2/2018

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Excerpt

Dear Editor, …
Appendix
Available only for authorised users
Literature
1.
Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, Horrow J, Husted S, James S, Katus H, Mahaffey KW, Scirica BM, Skene A, Steg PG, Storey RF, Harrington RA, PLATO Investigators, Freij A, Thorsén M (2009) Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361:1045–1057CrossRefPubMed
2.
Scirica BM, Cannon CP, Emanuelsson H, Michelson EL, Harrington RA, Husted S, James S, Katus H, Pais P, Raev D, Spinar J, Steg PG, Storey RF, Wallentin L, PLATO Investigators (2011) The incidence of bradyarrhythmias and clinical bradyarrhythmic events in patients with acute coronary syndromes treated with ticagrelor or clopidogrel in the PLATO (platelet inhibition and patient outcomes) trial. J Am Coll Cardiol 57:1908–1916CrossRefPubMed
3.
Cattaneo M, Schulz R, Nylander S (2014) Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevance. J Am Coll Cardiol 63:2503–2509CrossRefPubMed
4.
Bonello L, Laine M, Kipson N, Mancini J, Helal O, Fromonot J, Gariboldi V, Condo J, Thuny F, Frere C, Camoin-Jau L, Paganelli F, Dignat-George F, Guieu R (2014) Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome. J Am Coll Cardiol 63:872–877CrossRefPubMed
Metadata
Title
Is ticagrelor safe in intensive care unit patients? Focus on bradycardic events
Authors
Xavier Valette
Suzanne Goursaud
Joachim Alexandre
Maxime Leclerc
Vincent Roule
Farzin Beygui
Damien du Cheyron
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 2/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-5006-7

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