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Published in: Intensive Care Medicine 2/2018

01-02-2018 | What's New in Intensive Care

Fever control

Authors: Paul J. Young, Niklas Nielsen, Manoj Saxena

Published in: Intensive Care Medicine | Issue 2/2018

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Excerpt

Fever is a commonly encountered phenomenon in the intensive care unit (ICU) which has both potential benefits and potential risks for patients. Among patients with infections who are admitted to the ICU, increasing fever is independently associated with a decreasing risk of in-hospital mortality [1, 2]. From an evolutionary perspective, fever is a broadly conserved biological response to infection, and thus one might expect that for patients with infection, the febrile response could have benefits. Even in the absence of infection, low-grade fever appears to be independently associated with reduced mortality risk compared with normothermia [1]. …
Literature
1.
go back to reference Young PJ, Saxena M, Beasley R, Bellomo R, Bailey M, Pilcher D, Finfer S, Harrison D, Myburgh J, Rowan K (2012) Early peak temperature and mortality in critically ill patients with or without infection. Intensive Care Med 38:437–444CrossRef Young PJ, Saxena M, Beasley R, Bellomo R, Bailey M, Pilcher D, Finfer S, Harrison D, Myburgh J, Rowan K (2012) Early peak temperature and mortality in critically ill patients with or without infection. Intensive Care Med 38:437–444CrossRef
2.
go back to reference Saxena M, Young P, Pilcher D, Bailey M, Harrison D, Bellomo R, Finfer S, Beasley R, Hyam J, Menon D, Rowan K, Myburgh J (2015) Early temperature and mortality in critically ill patients with acute neurological diseases: trauma and stroke differ from infection. Intensive Care Med 41:823–832CrossRefPubMedPubMedCentral Saxena M, Young P, Pilcher D, Bailey M, Harrison D, Bellomo R, Finfer S, Beasley R, Hyam J, Menon D, Rowan K, Myburgh J (2015) Early temperature and mortality in critically ill patients with acute neurological diseases: trauma and stroke differ from infection. Intensive Care Med 41:823–832CrossRefPubMedPubMedCentral
3.
go back to reference Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP (2015) Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Hum Mol Genet 24:1801–1812CrossRefPubMed Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP (2015) Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Hum Mol Genet 24:1801–1812CrossRefPubMed
4.
go back to reference Manthous CA, Hall JB, Olson D, Singh M, Chatila W, Pohlman A, Kushner R, Schmidt GA, Wood LD (1995) Effect of cooling on oxygen consumption in febrile critically ill patients. Am J Respir Crit Care Med 151:10–14CrossRefPubMed Manthous CA, Hall JB, Olson D, Singh M, Chatila W, Pohlman A, Kushner R, Schmidt GA, Wood LD (1995) Effect of cooling on oxygen consumption in febrile critically ill patients. Am J Respir Crit Care Med 151:10–14CrossRefPubMed
5.
go back to reference Saxena MK, Taylor C, Billot L, Bompoint S, Gowardman J, Roberts JA (2015) The effect of paracetamol on core body temperature in acute traumatic brain injury: a randomised, controlled clinical trial. Plos One 10:e0144740CrossRefPubMedPubMedCentral Saxena MK, Taylor C, Billot L, Bompoint S, Gowardman J, Roberts JA (2015) The effect of paracetamol on core body temperature in acute traumatic brain injury: a randomised, controlled clinical trial. Plos One 10:e0144740CrossRefPubMedPubMedCentral
6.
go back to reference Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, Haren F (2015) Acetaminophen for fever in critically ill patients with suspected infection. N Engl J Med 373:2215–2224CrossRefPubMed Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, Haren F (2015) Acetaminophen for fever in critically ill patients with suspected infection. N Engl J Med 373:2215–2224CrossRefPubMed
7.
go back to reference Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, Janis LS, Wilde E, Taylor P, Harshman K, Conley A, Puccio A, Levin HS, McCauley SR, Bucholz RD, Smith KR, Schmidt JH, Scott JN, Yonas H, Okonkwo DO (2011) Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol 10:131–139CrossRefPubMed Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, Janis LS, Wilde E, Taylor P, Harshman K, Conley A, Puccio A, Levin HS, McCauley SR, Bucholz RD, Smith KR, Schmidt JH, Scott JN, Yonas H, Okonkwo DO (2011) Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol 10:131–139CrossRefPubMed
8.
go back to reference Andrews PJ, Sinclair HL, Rodriguez A, Harris BA, Battison CG, Rhodes JK (2015) Hypothermia for intracranial hypertension after traumatic brain injury. N Engl J Med 373:2403–2412CrossRefPubMed Andrews PJ, Sinclair HL, Rodriguez A, Harris BA, Battison CG, Rhodes JK (2015) Hypothermia for intracranial hypertension after traumatic brain injury. N Engl J Med 373:2403–2412CrossRefPubMed
9.
go back to reference Ntaios G, Dziedzic T, Michel P, Papavasileiou V, Petersson J, Staykov D, Thomas B, Steiner T, European Stroke O (2015) European Stroke Organisation (ESO) guidelines for the management of temperature in patients with acute ischemic stroke. Int J Stroke 10:941–949CrossRefPubMed Ntaios G, Dziedzic T, Michel P, Papavasileiou V, Petersson J, Staykov D, Thomas B, Steiner T, European Stroke O (2015) European Stroke Organisation (ESO) guidelines for the management of temperature in patients with acute ischemic stroke. Int J Stroke 10:941–949CrossRefPubMed
10.
go back to reference den Hertog HM, van der Worp HB, van Gemert HM, Algra A, Kappelle LJ, van Gijn J, Koudstaal PJ, Dippel DW, PAIS Investigators (2009) The Paracetamol (Acetaminophen) in Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. Lancet Neurol 8:434–440CrossRef den Hertog HM, van der Worp HB, van Gemert HM, Algra A, Kappelle LJ, van Gijn J, Koudstaal PJ, Dippel DW, PAIS Investigators (2009) The Paracetamol (Acetaminophen) in Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. Lancet Neurol 8:434–440CrossRef
11.
go back to reference Nielsen N, Friberg H, Gluud C, Herlitz J, Wetterslev J (2011) Hypothermia after cardiac arrest should be further evaluated–a systematic review of randomised trials with meta-analysis and trial sequential analysis. Int J Cardiol 151:333–341CrossRefPubMed Nielsen N, Friberg H, Gluud C, Herlitz J, Wetterslev J (2011) Hypothermia after cardiac arrest should be further evaluated–a systematic review of randomised trials with meta-analysis and trial sequential analysis. Int J Cardiol 151:333–341CrossRefPubMed
12.
go back to reference Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Aneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Kober L, Langorgen J, Lilja G, Moller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H, TTM Trial Investigators (2013) Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 369:2197–2206CrossRefPubMed Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Aneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Kober L, Langorgen J, Lilja G, Moller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H, TTM Trial Investigators (2013) Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 369:2197–2206CrossRefPubMed
13.
go back to reference Mourvillier B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D, Chillet P, Clair B, Constantin JM, Duguet A, Galliot R, Bayle F, Hyvernat H, Ouchenir K, Plantefeve G, Quenot JP, Richecoeur J, Schwebel C, Sirodot M, Esposito-Farese M, Le Tulzo Y, Wolff M (2013) Induced hypothermia in severe bacterial meningitis: a randomized clinical trial. JAMA 310:2174–2183CrossRefPubMed Mourvillier B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D, Chillet P, Clair B, Constantin JM, Duguet A, Galliot R, Bayle F, Hyvernat H, Ouchenir K, Plantefeve G, Quenot JP, Richecoeur J, Schwebel C, Sirodot M, Esposito-Farese M, Le Tulzo Y, Wolff M (2013) Induced hypothermia in severe bacterial meningitis: a randomized clinical trial. JAMA 310:2174–2183CrossRefPubMed
14.
go back to reference Schortgen F, Clabault K, Katsahian S, Devaquet J, Mercat A, Deye N (2012) Fever control using external cooling in septic shock: a randomized controlled trial. Am J Respir Crit Care Med 185:1088–1095CrossRefPubMed Schortgen F, Clabault K, Katsahian S, Devaquet J, Mercat A, Deye N (2012) Fever control using external cooling in septic shock: a randomized controlled trial. Am J Respir Crit Care Med 185:1088–1095CrossRefPubMed
15.
go back to reference Young PJ, Bailey MJ, Beasley RW, Freebairn RC, Hammond NE, Haren FM, Harward ML, Henderson SJ, Mackle DM, McArthur CJ, McGuinness SP, Myburgh JA, Saxena MK, Turner A, Webb SA, Bellomo R, the ANZICS CTG (2017) Protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial. Crit Care Resusc 19:81–87PubMed Young PJ, Bailey MJ, Beasley RW, Freebairn RC, Hammond NE, Haren FM, Harward ML, Henderson SJ, Mackle DM, McArthur CJ, McGuinness SP, Myburgh JA, Saxena MK, Turner A, Webb SA, Bellomo R, the ANZICS CTG (2017) Protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial. Crit Care Resusc 19:81–87PubMed
Metadata
Title
Fever control
Authors
Paul J. Young
Niklas Nielsen
Manoj Saxena
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 2/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-4969-8

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