Skip to main content
Top
Published in: Intensive Care Medicine 7/2017

01-07-2017 | Focus Editorial

Focus on severe infections

Authors: Kevin B. Laupland, Jose-Artur Paiva, Jean-Francois Timsit

Published in: Intensive Care Medicine | Issue 7/2017

Login to get access

Excerpt

The epidemiology of severe infections is changing worldwide. As a result of many complex factors not limited to globalization of economies and increased travel, intensivists are increasingly challenged to manage patients with unusual etiologies and increased resistance profiles with the associated risk of treatment failure. While a comprehensive review of this area is beyond the scope of this series, this article aims to highlight some selected recent publications examining severe tropical viral diseases, early diagnosis of infection, and means to optimize therapies for infected patients admitted to the ICU. …
Literature
1.
go back to reference Jog S, Prayag S, Rajhans P, Zirpe K, Dixit S, Pillai L, Shah J, Penurkar M, Kakrani A, Yadav A, Kadapatti K, Pawar B, Salunke D, Joshi P, Deshpande A, Gurav S, Patel D (2015) Dengue infection with multiorgan dysfunction: SOFA score, arterial lactate and serum albumin levels are predictors of outcome. Intensive Care Med 41:2029–2030CrossRefPubMed Jog S, Prayag S, Rajhans P, Zirpe K, Dixit S, Pillai L, Shah J, Penurkar M, Kakrani A, Yadav A, Kadapatti K, Pawar B, Salunke D, Joshi P, Deshpande A, Gurav S, Patel D (2015) Dengue infection with multiorgan dysfunction: SOFA score, arterial lactate and serum albumin levels are predictors of outcome. Intensive Care Med 41:2029–2030CrossRefPubMed
2.
go back to reference Bozza FA, Grinsztejn B (2016) Key points on Zika infection for the intensivist. Intensive Care Med 42:1490–1492CrossRefPubMed Bozza FA, Grinsztejn B (2016) Key points on Zika infection for the intensivist. Intensive Care Med 42:1490–1492CrossRefPubMed
3.
go back to reference Cao-Lormeau VM, Blake A, Mons S, Lastere S, Roche C, Vanhomwegen J, Dub T, Baudouin L, Teissier A, Larre P, Vial AL, Decam C, Choumet V, Halstead SK, Willison HJ, Musset L, Manuguerra JC, Despres P, Fournier E, Mallet HP, Musso D, Fontanet A, Neil J, Ghawche F (2016) Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 387:1531–1539CrossRefPubMedPubMedCentral Cao-Lormeau VM, Blake A, Mons S, Lastere S, Roche C, Vanhomwegen J, Dub T, Baudouin L, Teissier A, Larre P, Vial AL, Decam C, Choumet V, Halstead SK, Willison HJ, Musset L, Manuguerra JC, Despres P, Fournier E, Mallet HP, Musso D, Fontanet A, Neil J, Ghawche F (2016) Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 387:1531–1539CrossRefPubMedPubMedCentral
4.
go back to reference Yazdanpanah Y, Arribas JR, Malvy D (2015) Treatment of Ebola virus disease. Intensive Care Med 41:115–117CrossRefPubMed Yazdanpanah Y, Arribas JR, Malvy D (2015) Treatment of Ebola virus disease. Intensive Care Med 41:115–117CrossRefPubMed
5.
go back to reference Bordes J, Janvier F, Aletti M, de Greslan T, Gagnon N, Cotte J, Rousseau C, Billhot M, Cournac JM, Karkowski L, Moroge S, Duron S, Carmoi T, Cellarier G (2015) Organ failures on admission in patients with Ebola virus disease. Intensive Care Med 41:1504–1505CrossRefPubMed Bordes J, Janvier F, Aletti M, de Greslan T, Gagnon N, Cotte J, Rousseau C, Billhot M, Cournac JM, Karkowski L, Moroge S, Duron S, Carmoi T, Cellarier G (2015) Organ failures on admission in patients with Ebola virus disease. Intensive Care Med 41:1504–1505CrossRefPubMed
6.
go back to reference Uyeki TM, Mehta AK, Davey RT Jr, Liddell AM, Wolf T, Vetter P, Schmiedel S, Grunewald T, Jacobs M, Arribas JR, Evans L, Hewlett AL, Brantsaeter AB, Ippolito G, Rapp C, Hoepelman AI, Gutman J (2016) Clinical management of Ebola virus disease in the United States and Europe. N Engl J Med 374:636–646CrossRefPubMedPubMedCentral Uyeki TM, Mehta AK, Davey RT Jr, Liddell AM, Wolf T, Vetter P, Schmiedel S, Grunewald T, Jacobs M, Arribas JR, Evans L, Hewlett AL, Brantsaeter AB, Ippolito G, Rapp C, Hoepelman AI, Gutman J (2016) Clinical management of Ebola virus disease in the United States and Europe. N Engl J Med 374:636–646CrossRefPubMedPubMedCentral
7.
go back to reference Decousser JW, Poirel L, Nordmann P (2017) Recent advances in biochemical and molecular diagnostics for the rapid detection of antibiotic-resistant Enterobacteriaceae: a focus on ss-lactam resistance. Exp Rev Mol Diagn 17:327–350CrossRef Decousser JW, Poirel L, Nordmann P (2017) Recent advances in biochemical and molecular diagnostics for the rapid detection of antibiotic-resistant Enterobacteriaceae: a focus on ss-lactam resistance. Exp Rev Mol Diagn 17:327–350CrossRef
8.
go back to reference Warhurst G, Maddi S, Dunn G, Ghrew M, Chadwick P, Alexander P, Bentley A, Moore J, Sharman M, Carlson GL, Young D, Dark P (2015) Diagnostic accuracy of SeptiFast multi-pathogen real-time PCR in the setting of suspected healthcare-associated bloodstream infection. Intensive Care Med 41:86–93CrossRefPubMed Warhurst G, Maddi S, Dunn G, Ghrew M, Chadwick P, Alexander P, Bentley A, Moore J, Sharman M, Carlson GL, Young D, Dark P (2015) Diagnostic accuracy of SeptiFast multi-pathogen real-time PCR in the setting of suspected healthcare-associated bloodstream infection. Intensive Care Med 41:86–93CrossRefPubMed
9.
go back to reference Dark P, Blackwood B, Gates S, McAuley D, Perkins GD, McMullan R, Wilson C, Graham D, Timms K, Warhurst G (2015) Accuracy of LightCycler(®) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis. Intensive Care Med 41:21–33CrossRefPubMed Dark P, Blackwood B, Gates S, McAuley D, Perkins GD, McMullan R, Wilson C, Graham D, Timms K, Warhurst G (2015) Accuracy of LightCycler(®) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis. Intensive Care Med 41:21–33CrossRefPubMed
10.
go back to reference Jamal W, Al Roomi E, AbdulAziz LR, Rotimi VO (2014) Evaluation of Curetis Unyvero, a multiplex PCR-based testing system, for rapid detection of bacteria and antibiotic resistance and impact of the assay on management of severe nosocomial pneumonia. J Clin Microbiol 52:2487–2492CrossRefPubMedPubMedCentral Jamal W, Al Roomi E, AbdulAziz LR, Rotimi VO (2014) Evaluation of Curetis Unyvero, a multiplex PCR-based testing system, for rapid detection of bacteria and antibiotic resistance and impact of the assay on management of severe nosocomial pneumonia. J Clin Microbiol 52:2487–2492CrossRefPubMedPubMedCentral
11.
go back to reference Douglas IS, Price CS, Overdier KH, Wolken RF, Metzger SW, Hance KR, Howson DC (2015) Rapid automated microscopy for microbiological surveillance of ventilator-associated pneumonia. Am J Respir Crit Care Med 191:566–573CrossRefPubMedPubMedCentral Douglas IS, Price CS, Overdier KH, Wolken RF, Metzger SW, Hance KR, Howson DC (2015) Rapid automated microscopy for microbiological surveillance of ventilator-associated pneumonia. Am J Respir Crit Care Med 191:566–573CrossRefPubMedPubMedCentral
12.
go back to reference Le Dorze M, Gault N, Foucrier A, Ruppe E, Mourvillier B, Woerther PL, Birgand G, Montravers P, Dilly MP, Tubach F, Andremont A, Timsit JF, Wolff M, Armand-Lefevre L (2015) Performance and impact of a rapid method combining mass spectrometry and direct antimicrobial susceptibility testing on treatment adequacy of patients with ventilator-associated pneumonia. Clin Microbiol Infect 21(468):e461–466 Le Dorze M, Gault N, Foucrier A, Ruppe E, Mourvillier B, Woerther PL, Birgand G, Montravers P, Dilly MP, Tubach F, Andremont A, Timsit JF, Wolff M, Armand-Lefevre L (2015) Performance and impact of a rapid method combining mass spectrometry and direct antimicrobial susceptibility testing on treatment adequacy of patients with ventilator-associated pneumonia. Clin Microbiol Infect 21(468):e461–466
13.
go back to reference Gutierrez-Gutierrez B, Perez-Galera S, Salamanca E, de Cueto M, Calbo E, Almirante B, Viale P, Oliver A, Pintado V, Gasch O, Martinez-Martinez L, Pitout J, Akova M, Pena C, Molina J, Hernandez A, Venditti M, Prim N, Origuen J, Bou G, Tacconelli E, Tumbarello M, Hamprecht A, Giamarellou H, Almela M, Perez F, Schwaber MJ, Bermejo J, Lowman W, Hsueh PR, Mora-Rillo M, Natera C, Souli M, Bonomo RA, Carmeli Y, Paterson DL, Pascual A, Rodriguez-Bano J (2016) A multinational, preregistered cohort study of beta-lactam/beta-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-beta-lactamase-producing Enterobacteriaceae. Antimicrob Agents Chemother 60:4159–4169CrossRefPubMedPubMedCentral Gutierrez-Gutierrez B, Perez-Galera S, Salamanca E, de Cueto M, Calbo E, Almirante B, Viale P, Oliver A, Pintado V, Gasch O, Martinez-Martinez L, Pitout J, Akova M, Pena C, Molina J, Hernandez A, Venditti M, Prim N, Origuen J, Bou G, Tacconelli E, Tumbarello M, Hamprecht A, Giamarellou H, Almela M, Perez F, Schwaber MJ, Bermejo J, Lowman W, Hsueh PR, Mora-Rillo M, Natera C, Souli M, Bonomo RA, Carmeli Y, Paterson DL, Pascual A, Rodriguez-Bano J (2016) A multinational, preregistered cohort study of beta-lactam/beta-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-beta-lactamase-producing Enterobacteriaceae. Antimicrob Agents Chemother 60:4159–4169CrossRefPubMedPubMedCentral
14.
go back to reference Bassetti M, Rodriguez-Bano J (2016) Should we take into account ESBLs in empirical antibiotic treatment? Intensive Care Med 42:2059–2062CrossRef Bassetti M, Rodriguez-Bano J (2016) Should we take into account ESBLs in empirical antibiotic treatment? Intensive Care Med 42:2059–2062CrossRef
15.
16.
go back to reference Abdul-Aziz MH, Sulaiman H, Mat-Nor MB, Rai V, Wong KK, Hasan MS, Abd Rahman AN, Jamal JA, Wallis SC, Lipman J, Staatz CE, Roberts JA (2016) Beta-lactam infusion in severe sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Med 42:1535–1545CrossRefPubMed Abdul-Aziz MH, Sulaiman H, Mat-Nor MB, Rai V, Wong KK, Hasan MS, Abd Rahman AN, Jamal JA, Wallis SC, Lipman J, Staatz CE, Roberts JA (2016) Beta-lactam infusion in severe sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Med 42:1535–1545CrossRefPubMed
17.
go back to reference Burnham JP, Kirby JP, Kollef MH (2016) Diagnosis and management of skin and soft tissue infections in the intensive care unit: a review. Intensive Care Med 42:1899–1911CrossRefPubMed Burnham JP, Kirby JP, Kollef MH (2016) Diagnosis and management of skin and soft tissue infections in the intensive care unit: a review. Intensive Care Med 42:1899–1911CrossRefPubMed
18.
go back to reference Falcone M, Russo A, Farcomeni A, Pieralli F, Vannucchi V, Vullo V, Violi F, Venditti M (2016) Septic shock from community-onset pneumonia: is there a role for aspirin plus macrolides combination? Intensive Care Med 42:301–302CrossRefPubMed Falcone M, Russo A, Farcomeni A, Pieralli F, Vannucchi V, Vullo V, Violi F, Venditti M (2016) Septic shock from community-onset pneumonia: is there a role for aspirin plus macrolides combination? Intensive Care Med 42:301–302CrossRefPubMed
19.
go back to reference De Waele JJ, Schouten J, Dimopoulos G (2016) Understanding antibiotic stewardship for the critically ill. Intensive Care Med 42:2063–2065CrossRefPubMed De Waele JJ, Schouten J, Dimopoulos G (2016) Understanding antibiotic stewardship for the critically ill. Intensive Care Med 42:2063–2065CrossRefPubMed
Metadata
Title
Focus on severe infections
Authors
Kevin B. Laupland
Jose-Artur Paiva
Jean-Francois Timsit
Publication date
01-07-2017
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 7/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-4835-8

Other articles of this Issue 7/2017

Intensive Care Medicine 7/2017 Go to the issue