Skip to main content
Top
Published in: Intensive Care Medicine 1/2018

01-01-2018 | What's New in Intensive Care

Intensive care medicine in 2050: ventilator-induced lung injury

Authors: Luciano Gattinoni, Tommaso Tonetti, Michael Quintel

Published in: Intensive Care Medicine | Issue 1/2018

Login to get access

Excerpt

The side effects of mechanical ventilation belong to two mainstreams: the first involves the lung, the second the hemodynamics. The former relates to the transpulmonary pressure (i.e., the always-positive force distending the lung parenchyma), the latter relates to the intrathoracic pressure (i.e., the positive or negative force hindering or favoring the venous return though a variety of mechanisms). …
Literature
1.
go back to reference Kumar A et al (1973) Pulmonary barotrauma during mechanical ventilation. Crit Care Med 1(4):181–186CrossRefPubMed Kumar A et al (1973) Pulmonary barotrauma during mechanical ventilation. Crit Care Med 1(4):181–186CrossRefPubMed
2.
go back to reference Dreyfuss D et al (1988) High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 137(5):1159–1164CrossRefPubMed Dreyfuss D et al (1988) High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 137(5):1159–1164CrossRefPubMed
3.
go back to reference Tremblay L et al (1997) Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Investig 99(5):944–952CrossRefPubMedPubMedCentral Tremblay L et al (1997) Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Investig 99(5):944–952CrossRefPubMedPubMedCentral
4.
go back to reference Bellani G et al (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315(8):788–800CrossRefPubMed Bellani G et al (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315(8):788–800CrossRefPubMed
5.
go back to reference Esteban A et al (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287(3):345–355CrossRefPubMed Esteban A et al (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287(3):345–355CrossRefPubMed
6.
go back to reference Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342(18):1301–1308CrossRef Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342(18):1301–1308CrossRef
7.
go back to reference Brochard L et al (1998) Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. Am J Respir Crit Care Med 158(6):1831–1838CrossRefPubMed Brochard L et al (1998) Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. Am J Respir Crit Care Med 158(6):1831–1838CrossRefPubMed
8.
go back to reference Stewart TE et al (1998) Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med 338(6):355–361CrossRefPubMed Stewart TE et al (1998) Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med 338(6):355–361CrossRefPubMed
9.
go back to reference Brower RG et al (1999) Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 27(8):1492–1498CrossRefPubMed Brower RG et al (1999) Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 27(8):1492–1498CrossRefPubMed
10.
go back to reference Fanelli V et al (2016) Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome. Crit Care 20:36CrossRefPubMedPubMedCentral Fanelli V et al (2016) Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome. Crit Care 20:36CrossRefPubMedPubMedCentral
11.
go back to reference Dreyfuss D, Ricard JD, Gaudry S (2015) Did studies on HFOV fail to improve ARDS survival because they did not decrease VILI? On the potential validity of a physiological concept enounced several decades ago. Intensive Care Med 41(12):2076–2086CrossRefPubMed Dreyfuss D, Ricard JD, Gaudry S (2015) Did studies on HFOV fail to improve ARDS survival because they did not decrease VILI? On the potential validity of a physiological concept enounced several decades ago. Intensive Care Med 41(12):2076–2086CrossRefPubMed
12.
go back to reference Gattinoni L et al (2003) Physical and biological triggers of ventilator-induced lung injury and its prevention. Eur Respir J Suppl 47:15s–25sCrossRefPubMed Gattinoni L et al (2003) Physical and biological triggers of ventilator-induced lung injury and its prevention. Eur Respir J Suppl 47:15s–25sCrossRefPubMed
13.
go back to reference Gattinoni L et al (2016) Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med 42(10):1567–1575CrossRefPubMed Gattinoni L et al (2016) Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med 42(10):1567–1575CrossRefPubMed
14.
go back to reference Cressoni M et al (2014) Lung inhomogeneity in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 189(2):149–158PubMed Cressoni M et al (2014) Lung inhomogeneity in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 189(2):149–158PubMed
15.
go back to reference Pesenti A et al (2016) Imaging in acute respiratory distress syndrome. Intensive Care Med 42(5):686–698CrossRefPubMed Pesenti A et al (2016) Imaging in acute respiratory distress syndrome. Intensive Care Med 42(5):686–698CrossRefPubMed
Metadata
Title
Intensive care medicine in 2050: ventilator-induced lung injury
Authors
Luciano Gattinoni
Tommaso Tonetti
Michael Quintel
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 1/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-4770-8

Other articles of this Issue 1/2018

Intensive Care Medicine 1/2018 Go to the issue

Imaging in Intensive Care Medicine

Yellow urticaria following plasma transfusion