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01-09-2017 | Research Agenda

The intensive care medicine clinical research agenda in paediatrics

Authors: Mark J. Peters, Andrew Argent, Marino Festa, Stéphane Leteurtre, Jefferson Piva, Ann Thompson, Douglas Willson, Pierre Tissières, Marisa Tucci, Jacques Lacroix

Published in: Intensive Care Medicine | Issue 9/2017

Abstract

Background

Intensive Care Medicine set us the task of outlining a global clinical research agenda for paediatric intensive care (PIC). In line with the clinical focus of this journal, we have limited this to research that may directly influence patient care.

Methods

Clinician researchers from PIC research networks of varying degrees of formality from around the world were invited to answer two main questions: (1) What have been the major recent advances in paediatric critical care research? (2) What are the top 10 studies for the next 10 years?

Results

(1) Inclusive databases are well established in many countries. These registries allow detailed observational studies and feasibility testing of clinical trial protocols. Recent trials are larger and more valuable, and (2) most common interventions in PIC are not evidenced-based. Clinical studies for the next 10 years should address this deficit, including: ventilation techniques and interfaces; fluid, transfusion and feeding strategies; optimal targets for vital signs; multiple organ failure definitions, mechanisms and treatments; trauma, prevention and treatment; improving safety; comfort of the patient and their family; appropriate care in the face of medical complexity; defining post-PICU outcomes; and improving knowledge generation and adoption, with novel trial design and implementation strategies. The group specifically highlighted the need for research in resource-limited environments wherein mortality remains often tenfold higher than in well-resourced settings.

Conclusion

Paediatric intensive care research has never been healthier, but many gaps in knowledge remain. We need to close these urgently. The impact of new knowledge will be greatest in resource-limited environments.

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Title: The intensive care medicine clinical research agenda in paediatrics
Authors: Mark J. Peters
Andrew Argent
Marino Festa
Stéphane Leteurtre
Jefferson Piva
Ann Thompson
Douglas Willson
Pierre Tissières
Marisa Tucci
Jacques Lacroix
Publication date: 01-09-2017
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 9/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-017-4729-9

At a glance: The STEP trials

Springer Medicine

The intensive care medicine clinical research agenda in paediatrics

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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