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Intensive Care Medicine
Published in: Intensive Care Medicine 4/2017

01-04-2017 | Editorial

What do sepsis-induced coagulation test result abnormalities mean to intensivists?

Authors: Marcel Levi, Marcus J. Schultz

Published in: Intensive Care Medicine | Issue 4/2017

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Excerpt

Sepsis is frequently associated with abnormal coagulation test results, with deviations ranging from delicate activation of coagulation that can only be recognized by highly sensitive assays to stronger hemostatic activation like a fall in platelet count and elongations of global clotting assays and more outspoken manifestations of coagulation activation such as fulminant disseminated intravascular coagulation (DIC) [1]. …
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Angstwurm MW, Dempfle CE, Spannagl M (2006) New disseminated intravascular coagulation score: a useful tool to predict mortality in comparison with acute physiology and chronic health evaluation II and logistic organ dysfunction scores. Crit Care Med 34(2):314–320 (quiz 28)CrossRefPubMed
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Couto-Alves A, Wright VJ, Perumal K, Binder A, Carrol ED, Emonts M et al (2013) A new scoring system derived from base excess and platelet count at presentation predicts mortality in paediatric meningococcal sepsis. Crit Care 17(2):R68CrossRefPubMedPubMedCentral
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Schwameis M, Steiner MM, Schoergenhofer C, Lagler H, Buchtele N, Jilma-Stohlawetz P et al (2015) D-dimer and histamine in early stage bacteremia: a prospective controlled cohort study. Eur J Intern Med 26(10):782–786CrossRefPubMed
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Vincent JL, Ramesh MK, Ernest D, LaRosa SP, Pachl J, Aikawa N et al (2013) A randomized, double-blind, placebo-controlled, phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med 41(9):2069–2079CrossRefPubMed
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Davies GR, Pillai S, Lawrence M, Mills GM, Aubrey R, D’Silva L et al (2016) The effect of sepsis and its inflammatory response on mechanical clot characteristics: a prospective observational study. Intensive Care Med 42(12):1990–1998. doi:10.​1007/​s00134-016-4496-z CrossRefPubMed
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Levi M, Hunt BJ (2015) A critical appraisal of point-of-care coagulation testing in critically ill patients. J Thromb Haemost 13(11):1960–1967
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Muller MC, Meijers JC, Vroom MB, Juffermans NP (2014) Utility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review. Crit Care 18(1):R30CrossRefPubMedPubMedCentral
Metadata
Title
What do sepsis-induced coagulation test result abnormalities mean to intensivists?
Authors
Marcel Levi
Marcus J. Schultz
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 4/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-4725-0

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