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01-01-2017 | Editorial

Paediatric cardiopulmonary bypass surgery: the challenges of heterogeneity and identifying a meaningful endpoint for clinical trials

Authors: V. J. Pappachan, K. L. Brown, S. M. Tibby

Published in: Intensive Care Medicine | Issue 1/2017

Excerpt

Survival following paediatric surgery for congenital heart disease (CHD) has improved dramatically over the past two decades; 30-day mortality estimates are now 2.5–4% [1]. However short- and long-term morbidity remain significant issues and hospital length of stay remains unchanged [1]. Both are costly and are linked to poorer long-term neurodevelopmental outcomes [2]. We are now operating on a greater proportion of younger, smaller patients; many with associated extra-cardiac anomalies and chromosomal disorders [3]. Ideally trials should report both immediate perioperative and post-discharge outcomes [4]. …

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Title: Paediatric cardiopulmonary bypass surgery: the challenges of heterogeneity and identifying a meaningful endpoint for clinical trials
Authors: V. J. Pappachan
K. L. Brown
S. M. Tibby
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 1/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-016-4622-y

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