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Intensive Care Medicine
Published in: Intensive Care Medicine 12/2016

01-12-2016 | Letter

De-escalation of pivotal beta-lactam in ventilator-associated pneumonia does not impact outcome and marginally affects MDR acquisition

Authors: E. Weiss, J. R. Zahar, M. Garrouste-Orgeas, S. Ruckly, W. Essaied, C. Schwebel, J. F. Timsit, On behalf of the OUTCOMEREA Study Group

Published in: Intensive Care Medicine | Issue 12/2016

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Excerpt

De-escalation (DE) consists in reappraisal of antimicrobial therapy as soon as microbiological susceptibility data are available. One of its aims is to limit the emergence and spread of multidrug-resistant (MDR) pathogens by reducing broad-spectrum antibiotic use [1]. …
Appendix
Available only for authorised users
Literature
1.
Tabah A, Cotta MO, Garnacho-Montero J, Schouten J, Roberts JA, Lipman J, Tacey M, Timsit JF, Leone M, Zahar JR, De Waele JJ, Working Group for Antimicrobial Use in the ICU (2016) A systematic review of the definitions, determinants, and clinical outcomes of antimicrobial de-escalation in the intensive care unit. Clin Infect Dis 62(8):1009–1017CrossRefPubMed
2.
Weiss E, Zahar JR, Lesprit P, Ruppe E, Leone M, Chastre J, Lucet JC, Paugam-Burtz C, Brun-Buisson C, Timsit JF, De-escalation Study Group (2015) Elaboration of a consensual definition of de-escalation allowing a ranking of beta-lactams. Clin Microbiol Infect 21(7):649 e1–649 e10CrossRef
3.
Armand-Lefevre L, Angebault C, Barbier F, Hamelet E, Defrance G, Ruppe E, Bronchard R, Lepeule R, Lucet JC, El Mniai A, Wolff M, Montravers P, Plesiat P, Andremont A (2013) Emergence of imipenem-resistant gram-negative bacilli in intestinal flora of intensive care patients. Antimicrob Agents Chemother 57(3):1488–1495CrossRefPubMedPubMedCentral
Metadata
Title
De-escalation of pivotal beta-lactam in ventilator-associated pneumonia does not impact outcome and marginally affects MDR acquisition
Authors
E. Weiss
J. R. Zahar
M. Garrouste-Orgeas
S. Ruckly
W. Essaied
C. Schwebel
J. F. Timsit
On behalf of the OUTCOMEREA Study Group
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 12/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-016-4448-7

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