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01-04-2016 | Focus Editorial

Focus on infection and sepsis in intensive care patients

Authors: Ignacio Martin-Loeches, Anders Perner

Published in: Intensive Care Medicine | Issue 4/2016

Excerpt

Over the last year, several papers have shed light on the management of severe infections and sepsis in intensive care units (ICU). With this overview, we will highlight the important new findings with a focus on infectious disease and sepsis in critically ill patients. …

Martin-Loeches I, Torres A, Rinaudo M et al (2015) Resistance patterns and outcomes in intensive care unit (ICU)-acquired pneumonia. Validation of European Centre for Disease Prevention and Control (ECDC) and the Centers for Disease Control and Prevention (CDC) classification of multidrug resistant organi. J Infect 70:213–222. doi:10.1016/j.jinf.2014.10.004 CrossRefPubMed

Vallés J, Martin-Loeches I, Torres A et al (2014) Epidemiology, antibiotic therapy and clinical outcomes of healthcare-associated pneumonia in critically ill patients: a Spanish cohort study. Intensive Care Med. doi:10.1007/s00134-014-3239-2 PubMed

Nair GB, Niederman MS (2015) Ventilator-associated pneumonia: present understanding and ongoing debates. Intensive Care Med 41:34–48. doi:10.1007/s00134-014-3564-5 CrossRefPubMed

Martin-Loeches I, Povoa P, Rodríguez A et al (2015) Incidence and prognosis of ventilator-associated tracheobronchitis (TAVeM): a multicentre, prospective, observational study. Lancet Respir Med 3:859–868. doi:10.1016/S2213-2600(15)00326-4 CrossRefPubMed

Bos LDJ, Martin-Loeches I, Artigas A (2014) Innovations that could improve early recognition of ventilator-associated pneumonia. Intensive Care Med 40:1352–1354

Albrich WC, Harbarth S (2015) Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting. Intensive Care Med 41:1739–1751. doi:10.1007/s00134-015-3978-8 CrossRefPubMed

Rodríguez AH, Avilés-Jurado FX, Díaz E et al (2015) Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: a CHAID decision-tree analysis. J Infect. doi:10.1016/j.jinf.2015.11.007

Martin-Loeches I, Bos LD, Povoa P et al (2015) Tumor necrosis factor receptor 1 (TNFRI) for ventilator-associated pneumonia diagnosis by cytokine multiplex analysis. Intensive Care Med Exp 3:26. doi:10.1186/s40635-015-0062-1 CrossRefPubMedPubMedCentral

Wolff M, Mourvillier B, Sonneville R, Timsit J-F (2014) My paper 10 years later: infective endocarditis in the intensive care unit. Intensive Care Med 40:1843–1852. doi:10.1007/s00134-014-3490-6 CrossRefPubMed

10.

Warhurst G, Maddi S, Dunn G et al (2015) Diagnostic accuracy of SeptiFast multi-pathogen real-time PCR in the setting of suspected healthcare-associated bloodstream infection. Intensive Care Med 41:86–93. doi:10.1007/s00134-014-3551-x CrossRefPubMed

11.

Dark P, Blackwood B, Gates S et al (2015) Accuracy of LightCycler^® SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis. Intensive Care Med 41:21–33. doi:10.1007/s00134-014-3553-8 CrossRefPubMed

12.

Chakrabarti A, Sood P, Rudramurthy SM et al (2015) Incidence, characteristics and outcome of ICU-acquired candidemia in India. Intensive Care Med 41:285–295. doi:10.1007/s00134-014-3603-2 CrossRefPubMed

13.

Colombo AL, Guimarães T, Sukienik T et al (2014) Prognostic factors and historical trends in the epidemiology of candidemia in critically ill patients: an analysis of five multicenter studies sequentially conducted over a 9-year period. Intensive Care Med 40:1489–1498. doi:10.1007/s00134-014-3400-y CrossRefPubMedPubMedCentral

14.

Bassetti M, Righi E, Ansaldi F et al (2015) A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality. Intensive Care Med 41:1601–1610. doi:10.1007/s00134-015-3866-2 CrossRefPubMed

15.

Martín-Mazuelos E, Loza A, Castro C et al (2015) β-d-Glucan and Candida albicans germ tube antibody in ICU patients with invasive candidiasis. Intensive Care Med 41:1424–1432. doi:10.1007/s00134-015-3922-y CrossRefPubMed

16.

Bailly S, Leroy O, Montravers P et al (2015) Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data. Intensive Care Med 41:1931–1940. doi:10.1007/s00134-015-4053-1 CrossRefPubMed

17.

León C, Ostrosky-Zeichner L, Schuster M (2014) What’s new in the clinical and diagnostic management of invasive candidiasis in critically ill patients. Intensive Care Med 40:808–819. doi:10.1007/s00134-014-3281-0 CrossRefPubMed

18.

Ferreira D, Grenouillet F, Blasco G et al (2015) Outcomes associated with routine systemic antifungal therapy in critically ill patients with Candida colonization. Intensive Care Med 41:1077–1088. doi:10.1007/s00134-015-3791-4 CrossRefPubMed

19.

Terraneo S, Ferrer M, Martín-Loeches I et al (2015) Impact of Candida spp. isolation in the respiratory tract in patients with intensive care unit-acquired pneumonia. Clin Microbiol Infect. doi:10.1016/j.cmi.2015.09.002 PubMed

20.

Albert M, Williamson D, Muscedere J et al (2014) Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study). Intensive Care Med 40:1313–1322. doi:10.1007/s00134-014-3352-2 CrossRefPubMed

Title: Focus on infection and sepsis in intensive care patients
Authors: Ignacio Martin-Loeches
Anders Perner
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 4/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-016-4234-6

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