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Published in: Intensive Care Medicine 5/2016

01-05-2016 | What's New in Intensive Care

Biomarkers of ARDS: what’s new?

Authors: Lorraine B. Ware, Carolyn S. Calfee

Published in: Intensive Care Medicine | Issue 5/2016

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Excerpt

Despite hundreds of studies of biomarkers in the acute respiratory distress syndrome (ARDS), there are no biomarkers of ARDS in use in clinical practice [1]. A recent meta-analysis highlights some of the limitations of current studies: small sample sizes, inadequate and inconsistent controls, and lack of large validation studies for many biomarkers [2]. Nevertheless, recent progress in several areas of biomarker research, including advances in the development of point-of-care testing technologies, has the potential to transform the application of biomarkers to clinical ARDS and may soon lead to the use of biomarkers at the bedside for diagnosis, risk stratification, and molecular phenotyping. …
Literature
1.
go back to reference Janz DR, Ware LB (2013) Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials. Semin Respir Crit Care Med 34(4):537–548CrossRefPubMed Janz DR, Ware LB (2013) Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials. Semin Respir Crit Care Med 34(4):537–548CrossRefPubMed
2.
go back to reference Terpstra ML, Aman J, van Nieuw Amerongen GP, Groeneveld AB (2014) Plasma biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med 42(3):691–700CrossRefPubMed Terpstra ML, Aman J, van Nieuw Amerongen GP, Groeneveld AB (2014) Plasma biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med 42(3):691–700CrossRefPubMed
3.
go back to reference Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K et al (2006) Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med 173(9):1008–1015CrossRefPubMedPubMedCentral Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K et al (2006) Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med 173(9):1008–1015CrossRefPubMedPubMedCentral
4.
go back to reference Jabaudon M, Blondonnet R, Roszyk L, Bouvier D, Audard J, Clairefond G et al (2015) Soluble RAGE predicts impaired alveolar fluid clearance in acute respiratory distress syndrome. Am J Respir Crit Care Med. doi:10.1164/rccm.201501-0020OC Jabaudon M, Blondonnet R, Roszyk L, Bouvier D, Audard J, Clairefond G et al (2015) Soluble RAGE predicts impaired alveolar fluid clearance in acute respiratory distress syndrome. Am J Respir Crit Care Med. doi:10.​1164/​rccm.​201501-0020OC
5.
go back to reference Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N et al (2008) Plasma receptor for advanced glycation end-products and clinical outcomes in acute lung injury. Thorax 63:1083–1089CrossRefPubMedPubMedCentral Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N et al (2008) Plasma receptor for advanced glycation end-products and clinical outcomes in acute lung injury. Thorax 63:1083–1089CrossRefPubMedPubMedCentral
6.
go back to reference Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT et al (2010) Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest 137(2):288–296CrossRefPubMedPubMedCentral Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT et al (2010) Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest 137(2):288–296CrossRefPubMedPubMedCentral
7.
go back to reference Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR et al (2010) Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma 68(5):1121–1127CrossRefPubMedPubMedCentral Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR et al (2010) Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma 68(5):1121–1127CrossRefPubMedPubMedCentral
8.
go back to reference Brown RM, Semler MW, Zhao Z, Koyama T, Janz DR, May AK et al (2015) Plasma angiopoietin-2 (Ang2) and receptor for advanced glycation end products (RAGE) improve diagnosis of ARDS compared to provider clinical assessment in adult trauma patients. Am J Respir Crit Care Med 191:A4417 Brown RM, Semler MW, Zhao Z, Koyama T, Janz DR, May AK et al (2015) Plasma angiopoietin-2 (Ang2) and receptor for advanced glycation end products (RAGE) improve diagnosis of ARDS compared to provider clinical assessment in adult trauma patients. Am J Respir Crit Care Med 191:A4417
9.
go back to reference Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR et al (2013) Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care 17(5):R253CrossRefPubMedPubMedCentral Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR et al (2013) Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care 17(5):R253CrossRefPubMedPubMedCentral
10.
go back to reference Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J et al (2006) Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am J Pathol 169(1):86–95CrossRefPubMedPubMedCentral Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J et al (2006) Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am J Pathol 169(1):86–95CrossRefPubMedPubMedCentral
11.
12.
go back to reference Gerszten RE, Accurso F, Bernard GR, Caprioli RM, Klee EW, Klee GG et al (2008) Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI clinical proteomics programs. Am J Physiol Lung Cell Mol Physiol 295(1):L16–L22CrossRefPubMedPubMedCentral Gerszten RE, Accurso F, Bernard GR, Caprioli RM, Klee EW, Klee GG et al (2008) Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI clinical proteomics programs. Am J Physiol Lung Cell Mol Physiol 295(1):L16–L22CrossRefPubMedPubMedCentral
13.
go back to reference McVey M, Tabuchi A, Kuebler WM (2012) Microparticles and acute lung injury. Am J Physiol Lung Cell Mol Physiol 303(5):L364–L381CrossRefPubMed McVey M, Tabuchi A, Kuebler WM (2012) Microparticles and acute lung injury. Am J Physiol Lung Cell Mol Physiol 303(5):L364–L381CrossRefPubMed
15.
go back to reference Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA et al (2015) Distinct molecular phenotypes of direct vs indirect ards in single-center and multicenter studies. Chest 147(6):1539–1548CrossRefPubMed Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA et al (2015) Distinct molecular phenotypes of direct vs indirect ards in single-center and multicenter studies. Chest 147(6):1539–1548CrossRefPubMed
16.
go back to reference Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L et al (2012) The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med 18(8):1217–1223CrossRefPubMed Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L et al (2012) The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med 18(8):1217–1223CrossRefPubMed
17.
go back to reference Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M et al (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351(4):327–336CrossRefPubMed Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M et al (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351(4):327–336CrossRefPubMed
18.
go back to reference Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N et al (2011) Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med 39(11):2511–2517CrossRefPubMedPubMedCentral Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N et al (2011) Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med 39(11):2511–2517CrossRefPubMedPubMedCentral
Metadata
Title
Biomarkers of ARDS: what’s new?
Authors
Lorraine B. Ware
Carolyn S. Calfee
Publication date
01-05-2016
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 5/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-015-3973-0

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