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Intensive Care Medicine
Published in: Intensive Care Medicine 6/2015

01-06-2015 | Systematic Review

Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis

Authors: Filippo Sanfilippo, Carlos Corredor, Nick Fletcher, Giora Landesberg, Umberto Benedetto, Pierre Foex, Maurizio Cecconi

Published in: Intensive Care Medicine | Issue 6/2015

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Abstract

Background

Myocardial dysfunction may contribute to the haemodynamic instability which accompanies sepsis, and may result in circulatory failure. There is no association between systolic dysfunction (SD) and mortality in septic patients and there is conflicting evidence regarding the effects of diastolic dysfunction (DD) on mortality in septic patients.

Methods

We conducted a systematic review and meta-analysis to investigate DD and mortality in septic patients. We included studies conducted in this patient population which investigated the association between DD reported according to tissue Doppler imaging (TDI) criteria and mortality, using the longest reported follow-up. As a secondary endpoint, we evaluated the association between SD and mortality according to the results reported by the retrieved studies.

Results

We included seven studies in our meta-analysis with 636 septic patients, 48 % of them were found to have DD. We found a significant association between DD and mortality (RR 1.82, 95 % CI 1.12–2.97, p = 0.02). This finding remained valid in a further analysis which including an older study reporting DD without TDI criteria. Five studies reported data on SD for a total of 581 patients, 29.6 % of them with SD. No association was found between SD and mortality (RR 0.93, 95 % CI 0.62–1.39, p = 0.73). Looking at subgroups, there was a trend towards higher mortality comparing isolated DD or combined SD–DD vs normal heart function (p = 0.10 and p = 0.05, respectively).

Conclusions

Diastolic dysfunction is common in septic patients and it is associated with mortality. Systolic dysfunction is less common and is not associated with mortality in this group of patients.
Appendix
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Metadata
Title
Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis
Authors
Filippo Sanfilippo
Carlos Corredor
Nick Fletcher
Giora Landesberg
Umberto Benedetto
Pierre Foex
Maurizio Cecconi
Publication date
01-06-2015
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 6/2015
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-015-3748-7

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