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Intensive Care Medicine
Published in: Intensive Care Medicine 6/2015

01-06-2015 | Understanding the Disease

Understanding the benefits and harms of oxygen therapy

Authors: Pierre Asfar, Mervyn Singer, Peter Radermacher

Published in: Intensive Care Medicine | Issue 6/2015

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Excerpt

The Dr. Jekyll and Mr. Hyde character of oxygen (O2) is well established [1], with O2 the vital final electron acceptor within the respiratory chain, but also a strong oxidizer that leads to the formation of “reactive oxygen species” (ROS). Hyperoxia-related increases in ROS production are particularly pronounced during ischaemia/reperfusion (I/R) and hypoxia/reoxygenation [2]. This dichotomy also holds true for ATP synthesis and ROS formation. Approximately 2 % of mitochondrial O2 consumption is directed towards ROS production, i.e., the more ATP produced, the more ROS generated [2]. ROS also share friend-and-foe characteristics, in that despite their toxic potential they are vital players in host defence systems and as signaling molecules [3]. …
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Metadata
Title
Understanding the benefits and harms of oxygen therapy
Authors
Pierre Asfar
Mervyn Singer
Peter Radermacher
Publication date
01-06-2015
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 6/2015
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-015-3670-z

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