Skip to main content
Top
Published in: Intensive Care Medicine 12/2014

01-12-2014 | Editorial

A revival for immunoglobulin therapy in septic shock?

Authors: Julien Textoris, Thierry Calandra, Frédéric Pène

Published in: Intensive Care Medicine | Issue 12/2014

Login to get access

Excerpt

As of 13 September 2014, World Sepsis Day, sepsis remains a leading cause of death worldwide. Over the last decade, the implementation of guidelines or bundles has had a major impact on the management of sepsis patients, stressing the need for prompt diagnosis and therapy including (1) early administration of antibiotics and source control, (2) hemodynamic resuscitation, and (3) prevention and management of organ failures. Besides antimicrobial therapy and supportive care, no immunomodulatory strategy has yielded clear-cut and reproducible results in terms of improved survival [1]. …
Literature
1.
go back to reference Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862–874PubMedCrossRef Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862–874PubMedCrossRef
2.
go back to reference Gatterre P, Oualha M, Dupic L, Iserin F, Bodemer C, Lesage F, Hubert P (2012) Kawasaki disease: an unexpected etiology of shock and multiple organ dysfunction syndrome. Intensive Care Med 38:872–878PubMedCrossRef Gatterre P, Oualha M, Dupic L, Iserin F, Bodemer C, Lesage F, Hubert P (2012) Kawasaki disease: an unexpected etiology of shock and multiple organ dysfunction syndrome. Intensive Care Med 38:872–878PubMedCrossRef
3.
go back to reference Schwab I, Nimmerjahn F (2013) Intravenous immunoglobulin therapy: how does IgG modulate the immune system? Nat Rev Immunol 13:176–189PubMedCrossRef Schwab I, Nimmerjahn F (2013) Intravenous immunoglobulin therapy: how does IgG modulate the immune system? Nat Rev Immunol 13:176–189PubMedCrossRef
4.
go back to reference Shankar-Hari M, Spencer J, Sewell WA, Rowan KM, Singer M (2012) Bench-to-bedside review: immunoglobulin therapy for sepsis—biological plausibility from a critical care perspective. Crit Care 16:206PubMedCentralPubMedCrossRef Shankar-Hari M, Spencer J, Sewell WA, Rowan KM, Singer M (2012) Bench-to-bedside review: immunoglobulin therapy for sepsis—biological plausibility from a critical care perspective. Crit Care 16:206PubMedCentralPubMedCrossRef
5.
go back to reference Jayasekera JP, Moseman EA, Carroll MC (2007) Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. J Virol 81:3487–3494PubMedCentralPubMedCrossRef Jayasekera JP, Moseman EA, Carroll MC (2007) Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. J Virol 81:3487–3494PubMedCentralPubMedCrossRef
6.
go back to reference Kinoshita M, Shinomiya N, Ono S, Tsujimoto H, Kawabata T, Matsumoto A, Hiraide H, Seki S (2006) Restoration of natural IgM production from liver B cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa. J Immunol 177:4627–4635PubMedCrossRef Kinoshita M, Shinomiya N, Ono S, Tsujimoto H, Kawabata T, Matsumoto A, Hiraide H, Seki S (2006) Restoration of natural IgM production from liver B cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa. J Immunol 177:4627–4635PubMedCrossRef
7.
go back to reference Ghumra A, Semblat JP, McIntosh RS, Raza A, Rasmussen IB, Braathen R, Johansen FE, Sandlie I, Mongini PK, Rowe JA, Pleass RJ (2008) Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). J Immunol 181:1988–2000PubMedCentralPubMedCrossRef Ghumra A, Semblat JP, McIntosh RS, Raza A, Rasmussen IB, Braathen R, Johansen FE, Sandlie I, Mongini PK, Rowe JA, Pleass RJ (2008) Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). J Immunol 181:1988–2000PubMedCentralPubMedCrossRef
8.
go back to reference Quartier P, Potter PK, Ehrenstein MR, Walport MJ, Botto M (2005) Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro. Eur J Immunol 35:252–260PubMedCrossRef Quartier P, Potter PK, Ehrenstein MR, Walport MJ, Botto M (2005) Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro. Eur J Immunol 35:252–260PubMedCrossRef
9.
go back to reference Notley CA, Brown MA, Wright GP, Ehrenstein MR (2011) Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells. J Immunol 186:4967–4972PubMedCrossRef Notley CA, Brown MA, Wright GP, Ehrenstein MR (2011) Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells. J Immunol 186:4967–4972PubMedCrossRef
10.
go back to reference Alejandria MM, Lansang MA, Dans LF, Mantaring JB 3rd (2013) Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Cochrane Database Syst Rev 9:CD001090 Alejandria MM, Lansang MA, Dans LF, Mantaring JB 3rd (2013) Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Cochrane Database Syst Rev 9:CD001090
11.
go back to reference Dechartres A, Boutron I, Trinquart L, Charles P, Ravaud P (2011) Single-center trials show larger treatment effects than multicenter trials: evidence from a meta-epidemiologic study. Ann Intern Med 155:39–51PubMedCrossRef Dechartres A, Boutron I, Trinquart L, Charles P, Ravaud P (2011) Single-center trials show larger treatment effects than multicenter trials: evidence from a meta-epidemiologic study. Ann Intern Med 155:39–51PubMedCrossRef
12.
go back to reference Dechartres A, Altman DG, Trinquart L, Boutron I, Ravaud P (2014) Association between analytic strategy and estimates of treatment outcomes in meta-analyses. JAMA 312:623–630PubMedCrossRef Dechartres A, Altman DG, Trinquart L, Boutron I, Ravaud P (2014) Association between analytic strategy and estimates of treatment outcomes in meta-analyses. JAMA 312:623–630PubMedCrossRef
13.
go back to reference Gelfand EW (2006) Differences between IGIV products: impact on clinical outcome. Int Immunopharmacol 6:592–599PubMedCrossRef Gelfand EW (2006) Differences between IGIV products: impact on clinical outcome. Int Immunopharmacol 6:592–599PubMedCrossRef
14.
go back to reference Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39:165–228PubMedCrossRef Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39:165–228PubMedCrossRef
15.
go back to reference Cavazzuti I, Serafini G, Busani S, Rinaldi L, Biagioni E, Buoncristiano M, Girardis M (2014) Early therapy with IgM-enriched polyclonal immunoglobulin in patients with septic shock. Intensive Care Med. doi:10.1007/s00134-014-3474-6 PubMed Cavazzuti I, Serafini G, Busani S, Rinaldi L, Biagioni E, Buoncristiano M, Girardis M (2014) Early therapy with IgM-enriched polyclonal immunoglobulin in patients with septic shock. Intensive Care Med. doi:10.​1007/​s00134-014-3474-6 PubMed
16.
go back to reference Venet F, Gebeile R, Bancel J, Guignant C, Poitevin-Later F, Malcus C, Lepape A, Monneret G (2011) Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients. Int Immunopharmacol 11:2086–2090PubMedCrossRef Venet F, Gebeile R, Bancel J, Guignant C, Poitevin-Later F, Malcus C, Lepape A, Monneret G (2011) Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients. Int Immunopharmacol 11:2086–2090PubMedCrossRef
Metadata
Title
A revival for immunoglobulin therapy in septic shock?
Authors
Julien Textoris
Thierry Calandra
Frédéric Pène
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 12/2014
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-014-3506-2

Other articles of this Issue 12/2014

Intensive Care Medicine 12/2014 Go to the issue