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Intensive Care Medicine

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01-10-2014 | Correspondence

De-escalation in severe sepsis: still an important part of our armamentarium against antimicrobial resistance, of course!

Authors: Marc Leone, Carole Bechis, Karine Baumstarck

Published in: Intensive Care Medicine | Issue 10/2014

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Dear Editor, …

Kapoor G, Saigal S (2014) De-escalation in severe sepsis: still an important part of our armamentarium against antimicrobial resistance. Intensive Care Med. doi:10.1007/s00134-014-3476-4

Leone M, Bechis C, Baumstarck K, Lefrant JY, Albanèse J, Jaber S, Lepape A, Constantin JM, Papazian L, Bruder N, Allaouchiche B, Bézulier K, Antonini F, Textoris J, Martin C, for the AZUREA Network Investigators (2014) De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial. Intensive Care Med. doi:10.1007/s00134-014-3411-8

Leone M, Bourgoin A, Cambon S, Dubuc M, Albanèse J, Martin C (2003) Empirical antimicrobial therapy of septic shock patients: adequacy and impact on the outcome. Crit Care Med 31:462–467PubMedCrossRef

Mokart D, Slehofer G, Lambert J, Sannini A, Chow-Chine L, Brun JP, Berger P, Duran S, Faucher M, Blache JL, Saillard C, Vey N, Leone M (2014) De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an observational study. Intensive Care Med 40:41–49PubMedCrossRef

Garnacho-Montero J, Gutiérrez-Pizarraya A, Escoresca-Ortega A, Corcia-Palomo Y, Fernández-Delgado E, Herrera-Melero I, Ortiz-Leyba C, Márquez-Vácaro JA (2014) De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock. Intensive Care Med 40:32–40PubMedCrossRef

Title: De-escalation in severe sepsis: still an important part of our armamentarium against antimicrobial resistance, of course!
Authors: Marc Leone
Carole Bechis
Karine Baumstarck
Publication date: 01-10-2014
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 10/2014
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3479-1

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De-escalation in severe sepsis: still an important part of our armamentarium against antimicrobial resistance, of course!

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De-escalation in severe sepsis: still an important part of our armamentarium against antimicrobial resistance