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Intensive Care Medicine

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01-10-2014 | Correspondence

Comment on Adamzik et al.: An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality

Authors: Benjamin D. Singer, Franco R. D’Alessio

Published in: Intensive Care Medicine | Issue 10/2014

Excerpt

Dear Editor, …

Adamzik M, Broll J, Steinmann J et al (2013) An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality. Intensive Care Med 39:1743–1751. doi:10.1007/s00134-013-3036-3 PubMedCrossRef

D’Alessio FR, Tsushima K, Aggarwal NR et al (2009) CD4 + CD25 + Foxp3 + Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest 119:2898–2913. doi:10.1172/JCI36498 PubMedCrossRefPubMedCentral

Mock JR, Garibaldi BT, Aggarwal NR et al (2014) Foxp3(+) regulatory T cells promote lung epithelial proliferation. Mucosal Immunol. doi:10.1038/mi.2014.33 PubMed

Garibaldi BT, D’Alessio FR, Mock JR et al (2013) Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment. Am J Respir Cell Mol Biol 48:35–43. doi:10.1165/rcmb.2012-0198OC PubMedCrossRefPubMedCentral

Singer BD, King LS, D’Alessio FR (2014) Regulatory T cells as immunotherapy. Front Immunol 5:46. doi:10.3389/fimmu.2014.00046 PubMedCrossRefPubMedCentral

Title: Comment on Adamzik et al.: An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality
Authors: Benjamin D. Singer
Franco R. D’Alessio
Publication date: 01-10-2014
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 10/2014
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3399-0

At a glance: The STEP trials

Springer Medicine

Comment on Adamzik et al.: An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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