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Intensive Care Medicine
Published in: Intensive Care Medicine 9/2013

01-09-2013 | Original

Neurodevelopmental, educational and behavioral outcome at 8 years after neonatal ECMO: a nationwide multicenter study

Authors: Marlous J. Madderom, Jolanda J. C. M. Reuser, Elisabeth M. W. J. Utens, Joost van Rosmalen, Marlou Raets, Paul Govaert, Katerina Steiner, Saskia J. Gischler, Dick Tibboel, Arno F. J. van Heijst, Hanneke IJsselstijn

Published in: Intensive Care Medicine | Issue 9/2013

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Abstract

Purpose

Reporting neurodevelopmental outcome of 8-year-old children treated with neonatal extracorporeal membrane oxygenation (ECMO).

Methods

In a follow-up study in 135 8-year-old children who received neonatal ECMO between 1996 and 2001 we assessed intelligence (Revised Amsterdam Intelligence Test), concentration (Bourdon-Vos test), eye-hand coordination (Developmental Test of Visual-Motor Integration) and behavior (Child Behavior Checklist and Teacher Report Form).

Results

Intelligence fell within normal range (mean IQ 99.9, SD 17.7, n = 125) with 91 % of the children following regular education. Significantly more children attended special education (9 %) or received extra support in regular education (39 %) compared with normative data. Slower working speed (χ2 = 132.36, p < 0.001) and less accuracy (χ2 = 12.90, p < 0.001) were found on the Bourdon-Vos test (n = 123) compared with normative data. Eye-hand coordination fell within the normal range (mean 97.6, SD 14.3, n = 126); children with congenital diaphragmatic hernia scored lowest but still normally (mean 91.0, SD 16.4, n = 28). Mothers (n = 117) indicated more somatic and attention behavior problems; teachers (n = 115) indicated more somatic, social, thought, aggression and total problems compared with normative data. Mothers indicated more somatic problems than teachers (p = 0.003); teachers reported more attention problems than mothers (p = 0.036; n = 111).

Conclusions

Eight-year-old children treated with neonatal ECMO fall in the normal range of intelligence with problems with concentration and behavior. Long-term follow-up for children treated with neonatal ECMO should focus on early detection of (subtle) learning deficits.

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Metadata
Title
Neurodevelopmental, educational and behavioral outcome at 8 years after neonatal ECMO: a nationwide multicenter study
Authors
Marlous J. Madderom
Jolanda J. C. M. Reuser
Elisabeth M. W. J. Utens
Joost van Rosmalen
Marlou Raets
Paul Govaert
Katerina Steiner
Saskia J. Gischler
Dick Tibboel
Arno F. J. van Heijst
Hanneke IJsselstijn
Publication date
01-09-2013
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 9/2013
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-013-2973-1

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