Skip to main content
Top
Published in: Intensive Care Medicine 10/2011

Open Access 01-10-2011 | Pediatric Original

Ventilator-associated pneumonia in children after cardiac surgery in The Netherlands

Authors: P. P. Roeleveld, D. Guijt, E. J. Kuijper, M. G. Hazekamp, R. B. P. de Wilde, E. de Jonge

Published in: Intensive Care Medicine | Issue 10/2011

Login to get access

Abstract

Purpose

We conducted a retrospective cohort study in an academic tertiary care center to characterize ventilator-associated pneumonia (VAP) in pediatric patients after cardiac surgery in The Netherlands.

Methods

All patients following cardiac surgery and mechanically ventilated for ≥24 h were included. The primary outcome was development of VAP. Secondary outcomes were duration of mechanical ventilation and length of ICU stay.

Results

A total of 125 patients were enrolled. Their mean age was 16.5 months. The rate of VAP was 17.1/1,000 mechanical ventilation days. Frequently found organisms were Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Pseudomonas aeruginosa. Patients with VAP had longer duration of ventilation and longer ICU stay. Risk factors associated with the development of VAP were a PRISM III score of ≥10 and transfusion of fresh frozen plasma.

Conclusion

The mean VAP rate in this population is higher than that reported in general pediatric ICU populations. Children with VAP had a prolonged need for mechanical ventilation and a longer ICU stay.
Literature
1.
go back to reference Elward AM (2003) Pediatric ventilator-associated pneumonia. Pediatr Infect Dis J 22:445–446PubMed Elward AM (2003) Pediatric ventilator-associated pneumonia. Pediatr Infect Dis J 22:445–446PubMed
2.
go back to reference National Nosocomial Infections Surveillance (NNIS) System (2001) National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992–June 2001, issued August 2001. Am J Infect Control 29:404–421CrossRef National Nosocomial Infections Surveillance (NNIS) System (2001) National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992–June 2001, issued August 2001. Am J Infect Control 29:404–421CrossRef
3.
go back to reference Tang CW, Liu PY, Huang YF, Pan JY, Lee SS, Hsieh KS, Liu YC, Ger LP (2009) Ventilator-associated pneumonia after pediatric cardiac surgery in southern Taiwan. J Microbiol Immunol Infect 42:413–419PubMed Tang CW, Liu PY, Huang YF, Pan JY, Lee SS, Hsieh KS, Liu YC, Ger LP (2009) Ventilator-associated pneumonia after pediatric cardiac surgery in southern Taiwan. J Microbiol Immunol Infect 42:413–419PubMed
4.
go back to reference Chastre J, Fagon JY (2002) Ventilator-associated pneumonia. Am J Respir Crit Care Med 165:867–903PubMed Chastre J, Fagon JY (2002) Ventilator-associated pneumonia. Am J Respir Crit Care Med 165:867–903PubMed
5.
go back to reference Hortal J, Giannella M, Perez MJ, Barrio JM, Desco M, Bouza E, Munoz P (2009) Incidence and risk factors for ventilator-associated pneumonia after major heart surgery. Intensive Care Med 35:1518–1525PubMedCrossRef Hortal J, Giannella M, Perez MJ, Barrio JM, Desco M, Bouza E, Munoz P (2009) Incidence and risk factors for ventilator-associated pneumonia after major heart surgery. Intensive Care Med 35:1518–1525PubMedCrossRef
6.
go back to reference Elward AM, Warren DK, Fraser VJ (2002) Ventilator-associated pneumonia in pediatric intensive care unit patients: risk factors and outcomes. Pediatrics 109:758–764PubMedCrossRef Elward AM, Warren DK, Fraser VJ (2002) Ventilator-associated pneumonia in pediatric intensive care unit patients: risk factors and outcomes. Pediatrics 109:758–764PubMedCrossRef
7.
go back to reference Srinivasan R, Asselin J, Gildengorin G, Wiener-Kronish J, Flori HR (2009) A prospective study of ventilator-associated pneumonia in children. Pediatrics 123:1108–1115PubMedCrossRef Srinivasan R, Asselin J, Gildengorin G, Wiener-Kronish J, Flori HR (2009) A prospective study of ventilator-associated pneumonia in children. Pediatrics 123:1108–1115PubMedCrossRef
8.
go back to reference Almuneef M, Memish ZA, Balkhy HH, Alalem H, Abutaleb A (2004) Ventilator-associated pneumonia in a pediatric intensive care unit in Saudi Arabia: a 30-month prospective surveillance. Infect Control Hosp Epidemiol 25:753–758PubMedCrossRef Almuneef M, Memish ZA, Balkhy HH, Alalem H, Abutaleb A (2004) Ventilator-associated pneumonia in a pediatric intensive care unit in Saudi Arabia: a 30-month prospective surveillance. Infect Control Hosp Epidemiol 25:753–758PubMedCrossRef
9.
go back to reference Fischer JE, Allen P, Fanconi S (2000) Delay of extubation in neonates and children after cardiac surgery: impact of ventilator-associated pneumonia. Intensive Care Med 26:942–949PubMedCrossRef Fischer JE, Allen P, Fanconi S (2000) Delay of extubation in neonates and children after cardiac surgery: impact of ventilator-associated pneumonia. Intensive Care Med 26:942–949PubMedCrossRef
10.
go back to reference Tan L, Sun X, Zhu X, Zhang Z, Li J, Shu Q (2004) Epidemiology of nosocomial pneumonia in infants after cardiac surgery. Chest 125:410–417PubMedCrossRef Tan L, Sun X, Zhu X, Zhang Z, Li J, Shu Q (2004) Epidemiology of nosocomial pneumonia in infants after cardiac surgery. Chest 125:410–417PubMedCrossRef
11.
go back to reference Horan TC, Andrus M, Dudeck MA (2008) CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 36:309–332PubMedCrossRef Horan TC, Andrus M, Dudeck MA (2008) CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 36:309–332PubMedCrossRef
12.
go back to reference Jacobs JP, Jacobs ML, Lacour-Gayet FG, Jenkins KJ, Gauvreau K, Bacha E, Maruszewski B, Clarke DR, Tchervenkov CI, Gaynor JW, Spray TL, Stellin G, O’Bien SM, Elliott MJ, Mavroudis C (2009) Stratification of complexity improves the utility and accuracy of outcomes analysis in a Multi-Institutional Congenital Heart Surgery Database: Application of the Risk Adjustment in Congenital Heart Surgery (RACHS-1) and Aristotle Systems in the Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database. Pediatr Cardiol 30:1117–1130PubMedCrossRef Jacobs JP, Jacobs ML, Lacour-Gayet FG, Jenkins KJ, Gauvreau K, Bacha E, Maruszewski B, Clarke DR, Tchervenkov CI, Gaynor JW, Spray TL, Stellin G, O’Bien SM, Elliott MJ, Mavroudis C (2009) Stratification of complexity improves the utility and accuracy of outcomes analysis in a Multi-Institutional Congenital Heart Surgery Database: Application of the Risk Adjustment in Congenital Heart Surgery (RACHS-1) and Aristotle Systems in the Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database. Pediatr Cardiol 30:1117–1130PubMedCrossRef
13.
go back to reference Miller MA, Arndt JL, Konkle MA, Chenoweth CE, Iwashyna TJ, Flaherty KR, Hyzy RC (2011) A polyurethane cuffed endotracheal tube is associated with decreased rates of ventilator-associated pneumonia. J Crit Care 26:280–286PubMedCrossRef Miller MA, Arndt JL, Konkle MA, Chenoweth CE, Iwashyna TJ, Flaherty KR, Hyzy RC (2011) A polyurethane cuffed endotracheal tube is associated with decreased rates of ventilator-associated pneumonia. J Crit Care 26:280–286PubMedCrossRef
14.
go back to reference Poelaert J, Depuydt P, De Wolf A, Van de Velde S, Herck I, Blot S (2008) Polyurethane cuffed endotracheal tubes to prevent early postoperative pneumonia after cardiac surgery: a pilot study. J Thorac Cardiovasc Surg 135:771–776PubMedCrossRef Poelaert J, Depuydt P, De Wolf A, Van de Velde S, Herck I, Blot S (2008) Polyurethane cuffed endotracheal tubes to prevent early postoperative pneumonia after cardiac surgery: a pilot study. J Thorac Cardiovasc Surg 135:771–776PubMedCrossRef
15.
go back to reference National Nosocomial Infections Surveillance (NNIS) System (2004) National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 32:470–485CrossRef National Nosocomial Infections Surveillance (NNIS) System (2004) National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 32:470–485CrossRef
16.
go back to reference Raymond J, Aujard Y (2000) Nosocomial infections in pediatric patients: a European, multicenter prospective study. European study group. Infect Control Hosp Epidemiol 21:260–263PubMedCrossRef Raymond J, Aujard Y (2000) Nosocomial infections in pediatric patients: a European, multicenter prospective study. European study group. Infect Control Hosp Epidemiol 21:260–263PubMedCrossRef
17.
go back to reference Craven DE, Chroneou A, Zias N, Hjalmarson KI (2009) Ventilator-associated tracheobronchitis: the impact of targeted antibiotic therapy on patient outcomes. Chest 135:521–528PubMedCrossRef Craven DE, Chroneou A, Zias N, Hjalmarson KI (2009) Ventilator-associated tracheobronchitis: the impact of targeted antibiotic therapy on patient outcomes. Chest 135:521–528PubMedCrossRef
18.
go back to reference Mentec H, May-Michelangeli L, Rabbat A, Varon E, Le Turdu F, Bleichner G (2004) Blind and bronchoscopic sampling methods in suspected ventilator-associated pneumonia. A multicentre prospective study. Intensive Care Med 30:1319–1326PubMedCrossRef Mentec H, May-Michelangeli L, Rabbat A, Varon E, Le Turdu F, Bleichner G (2004) Blind and bronchoscopic sampling methods in suspected ventilator-associated pneumonia. A multicentre prospective study. Intensive Care Med 30:1319–1326PubMedCrossRef
19.
go back to reference Sachdev A, Chugh K, Sethi M, Gupta D, Wattal C, Menon G (2010) Diagnosis of ventilator-associated pneumonia in children in resource-limited setting: a comparative study of bronchoscopic and non-bronchoscopic methods. Pediatr Crit Care Med 11:258–266PubMedCrossRef Sachdev A, Chugh K, Sethi M, Gupta D, Wattal C, Menon G (2010) Diagnosis of ventilator-associated pneumonia in children in resource-limited setting: a comparative study of bronchoscopic and non-bronchoscopic methods. Pediatr Crit Care Med 11:258–266PubMedCrossRef
20.
go back to reference Pawar M, Mehta Y, Khurana P, Chaudhary A, Kulkarni V, Trehan N (2003) Ventilator-associated pneumonia: incidence, risk factors, outcome, and microbiology. J Cardiothorac Vasc Anesth 17:22–28PubMedCrossRef Pawar M, Mehta Y, Khurana P, Chaudhary A, Kulkarni V, Trehan N (2003) Ventilator-associated pneumonia: incidence, risk factors, outcome, and microbiology. J Cardiothorac Vasc Anesth 17:22–28PubMedCrossRef
21.
go back to reference Sarani B, Dunkman WJ, Dean L, Sonnad S, Rohrbach JI, Gracias VH (2008) Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med 36:1114–1118PubMedCrossRef Sarani B, Dunkman WJ, Dean L, Sonnad S, Rohrbach JI, Gracias VH (2008) Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med 36:1114–1118PubMedCrossRef
22.
go back to reference Hawe CS, Ellis KS, Cairns CJ, Longmate A (2009) Reduction of ventilator-associated pneumonia: active versus passive guideline implementation. Intensive Care Med 35:1180–1186PubMedCrossRef Hawe CS, Ellis KS, Cairns CJ, Longmate A (2009) Reduction of ventilator-associated pneumonia: active versus passive guideline implementation. Intensive Care Med 35:1180–1186PubMedCrossRef
23.
go back to reference Brilli RJ, Sparling KW, Lake MR, Butcher J, Myers SS, Clark MD, Helpling A, Stutler ME (2008) The business case for preventing ventilator-associated pneumonia in pediatric intensive care unit patients. Jt Comm J Qual Patient Saf 34:629–638PubMed Brilli RJ, Sparling KW, Lake MR, Butcher J, Myers SS, Clark MD, Helpling A, Stutler ME (2008) The business case for preventing ventilator-associated pneumonia in pediatric intensive care unit patients. Jt Comm J Qual Patient Saf 34:629–638PubMed
25.
go back to reference Bigham MT, Amato R, Bondurrant P, Fridriksson J, Krawczeski CD, Raake J, Ryckman S, Schwartz S, Shaw J, Wells D, Brilli RJ (2009) Ventilator-associated pneumonia in the pediatric intensive care unit: characterizing the problem and implementing a sustainable solution. J Pediatr 154:582–587PubMedCrossRef Bigham MT, Amato R, Bondurrant P, Fridriksson J, Krawczeski CD, Raake J, Ryckman S, Schwartz S, Shaw J, Wells D, Brilli RJ (2009) Ventilator-associated pneumonia in the pediatric intensive care unit: characterizing the problem and implementing a sustainable solution. J Pediatr 154:582–587PubMedCrossRef
26.
go back to reference Safdar N, Dezfulian C, Collard HR, Saint S (2005) Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 33:2184–2193PubMedCrossRef Safdar N, Dezfulian C, Collard HR, Saint S (2005) Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 33:2184–2193PubMedCrossRef
Metadata
Title
Ventilator-associated pneumonia in children after cardiac surgery in The Netherlands
Authors
P. P. Roeleveld
D. Guijt
E. J. Kuijper
M. G. Hazekamp
R. B. P. de Wilde
E. de Jonge
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 10/2011
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-011-2349-3

Other articles of this Issue 10/2011

Intensive Care Medicine 10/2011 Go to the issue