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Intensive Care Medicine
Published in: Intensive Care Medicine 6/2011

Open Access 01-06-2011 | Pediatric Original

Intracranial bleeding due to vitamin K deficiency: advantages of using a pediatric intensive care registry

Authors: Désirée Y. Visser, Nicolaas J. Jansen, Marloes M. Ijland, Tom J. de Koning, Peter M. van Hasselt

Published in: Intensive Care Medicine | Issue 6/2011

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Abstract

Aim

To determine the incidence of late intracranial vitamin K deficiency bleeding (VKDB) in The Netherlands using the Dutch Pediatric Intensive Care Evaluation (PICE) registry.

Methods

The PICE registry was used to identify all infants who were admitted to a Dutch pediatric intensive care unit (PICU) with intracranial bleeding between 1 January 2004 and 31 December 2007. Cases of confirmed late intracranial VKDB were used to calculate the incidence for each year. To estimate the completeness of ascertainment of the PICE registry, data from 2005 were compared with general surveillance data from that year.

Results

In the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2–3.5). The single-year incidence varied markedly between 0.5 and 3.3 per 100,000 live births. All five ascertained cases in 2005 were identified using the PICE registry, while general surveillance identified only three.

Conclusions

The PICE registry allows ongoing monitoring of the incidence of late intracranial VKDB and appears to be associated with a higher rate of completeness than general surveillance. We propose the use of pediatric intensive care registries to assess the efficacy of national vitamin K prophylactic regimens.
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Metadata
Title
Intracranial bleeding due to vitamin K deficiency: advantages of using a pediatric intensive care registry
Authors
Désirée Y. Visser
Nicolaas J. Jansen
Marloes M. Ijland
Tom J. de Koning
Peter M. van Hasselt
Publication date
01-06-2011
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 6/2011
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-011-2175-7

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