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01-06-2009 | Brief Report

Hypercapnia in late-phase ALI/ARDS: providing spontaneous breathing using pumpless extracorporeal lung assist

Authors: Steffen Weber-Carstens, Sven Bercker, Matthias Hommel, Maria Deja, Martin MacGuill, Christiane Dreykluft, Udo Kaisers

Published in: Intensive Care Medicine | Issue 6/2009

Abstract

Objective

The fibroproliferative phase of late ALI/ARDS as described by Hudson and Hough (Clin Chest Med 27:671–677, 2006) is associated with pronounced reductions in pulmonary compliance and an accompanying hypercapnia complicating low tidal volume mechanical ventilation. We report the effects of extracorporeal CO₂ removal by means of a novel pumpless extracorporeal lung assist (p-ECLA) on tidal volumes, airway pressures, breathing patterns and sedation management in pneumonia patients during late-phase ARDS.

Design

Retrospective analysis.

Setting

Fourteen-bed university hospital ICU.

Patients

Ten consecutive late-phase ALI/ARDS patients with low pulmonary compliance, and severe hypercapnia.

Intervention

Gas exchange, tidal volumes, airway pressures, breathing patterns and sedation requirements before (baseline) and after (2–4 days) initiation of treatment with p-ECLA were analysed. Patients were ventilated in a pressure-controlled mode with PEEP adjusted to pre-defined oxygenation goals.

Measurements and main results

Median reduction in pCO₂ was 50% following institution of p-ECLA. Extracorporeal CO₂ removal enabled significant reduction in tidal volumes (to below 4 ml/kg predicted body weight) and inspiratory plateau pressures [30 (28.5/32.3) cmH₂O, median 25, 75% percentiles]. Normalization of pCO₂ levels permitted significant reduction in the dosages of analgesics and sedatives. The proportion of assisted spontaneous breathing increased within 24 h of instituting p-ECLA.

Conclusion

Elimination of CO₂ by p-ECLA therapy allowed reduction of ventilator-induced shear stress through ventilation with tidal volumes below 4 ml/kg predicted body weight in pneumonia patients with severely impaired pulmonary compliance during late-phase ARDS. p-ECLA treatment supported control of breathing pattern while sedation requirements were reduced and facilitated the implementation of assisted spontaneous breathing.

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Title: Hypercapnia in late-phase ALI/ARDS: providing spontaneous breathing using pumpless extracorporeal lung assist
Authors: Steffen Weber-Carstens
Sven Bercker
Matthias Hommel
Maria Deja
Martin MacGuill
Christiane Dreykluft
Udo Kaisers
Publication date: 01-06-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 6/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-009-1426-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hypercapnia in late-phase ALI/ARDS: providing spontaneous breathing using pumpless extracorporeal lung assist

Abstract

Objective

Design

Setting

Patients

Intervention

Measurements and main results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patients

Intervention

Measurements and main results

Conclusion

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