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01-06-2008 | Original

Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial

Authors: Lorenzo Berra, Theodor Kolobow, Patrice Laquerriere, Betsey Pitts, Simone Bramati, Joshua Pohlmann, Chiara Marelli, Miriam Panzeri, Pietro Brambillasca, Federico Villa, Andrea Baccarelli, Sylvie Bouthors, Henry T. Stelfox, Luca M. Bigatello, Joel Moss, Antonio Pesenti

Published in: Intensive Care Medicine | Issue 6/2008

Abstract

Objective

Coated medical devices have been shown to reduce catheter-related infections. We coated endotracheal tubes (ETT) with silver sulfadiazine (SSD), and tested them in a clinical study to assess the feasibility, safety, and efficacy of preventing bacterial colonization.

Design

A prospective, randomized clinical trial, phase I–II.

Setting

Academic intensive care unit (ICU).

Participants

Forty-six adult patients expected to need 12–24 h of intubation were randomized into two groups.

Interventions

Patients were randomized to be intubated with a standard non-coated ETT (St-ETT, n = 23; control group), or with a SSD-coated ETT (SSD-ETT, n = 23).

Measurements and results

Coating with SSD prevented bacterial colonization of the ETT (frequency of colonization: SSD-ETT 0/23, St-ETT 8/23; p < 0.01). No organized bacterial biofilm could be identified on the lumen of any ETT; however, SSD was associated with a thinner mucus layer (in the SSD-ETT secretion deposits ranged from 0 to 200 μm; in the St-ETT deposits ranged between 50 and 700 μm). No difference was observed between the two groups in the tracheobronchial brush samples (frequency of colonization: SSD-ETT 0/23, St-ETT 2/23; p = 0.48). No adverse reactions were observed with the implementation of the novel device.

Conclusion

SSD-ETT can be safely used in preventing bacterial colonization and narrowing of the ETT in patients intubated for up to 24 h (mean intubation time 16 h).

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Title: Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial
Authors: Lorenzo Berra
Theodor Kolobow
Patrice Laquerriere
Betsey Pitts
Simone Bramati
Joshua Pohlmann
Chiara Marelli
Miriam Panzeri
Pietro Brambillasca
Federico Villa
Andrea Baccarelli
Sylvie Bouthors
Henry T. Stelfox
Luca M. Bigatello
Joel Moss
Antonio Pesenti
Publication date: 01-06-2008
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 6/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1100-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial

Abstract

Objective

Design

Setting

Participants

Interventions

Measurements and results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Design

Setting

Participants

Interventions

Measurements and results

Conclusion

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