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Intensive Care Medicine
Published in: Intensive Care Medicine 4/2008

01-04-2008 | Editorial

Haem oxygenase: A model for therapeutic intervention

Authors: Gregory J. Quinlan, Anna L. Lagan, Timothy W. Evans

Published in: Intensive Care Medicine | Issue 4/2008

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Excerpt

The haem oxygenase (HO) enzyme system was first identified in 1968 by Tenhunen and colleagues [1]. Inducible (HO-1) and constitutive (HO-2) isoforms were characterised in 1974 [2] and 1986 [3] respectively. Subsequently, a third isoform, HO-3, has been demonstrated in rats, although the significance of this finding remains a matter for debate [4]. HO-1 and -2 form part of an enzymatic pathway for haem catabolism and are principally involved in the conversion of haem to biliverdin. Equimolar amounts of carbon monoxide (CO) and ferrous iron are also produced as by-products of this reaction (Fig. 1). …
Literature
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Maines MD, Kappas A (1974) Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity. Proc Natl Acad Sci USA 71:4293–4297PubMedCrossRef
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Maines MD, Trakshel GM, Kutty RK (1986) Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible. J Biol Chem 261:411–419PubMed
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McCoubrey WK Jr, Huang TJ, Maines MD (1997) Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem 247:725–732PubMedCrossRef
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Bauer M, Huse K, Settmacher U, Claus RA (2008) The heme oxygenase–carbon monoxide system: regulation and role in stress response and organ failure. Intensive Care Med DOI 10.​1007/​s00134-008-1010-2
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Hirai H, Kubo H, Yamaya M, Nakayama K, Numasaki M, Kobayashi S, Suzuki S, Shibahara S, Sasaki H (2003) Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 102:1619–1621PubMedCrossRef
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Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, Sasaki H (2000) Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 66:187–195PubMedCrossRef
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Lagan AL, Quinlan GJ, Mumby S, Melley DD, Goldstraw P, Bellingan GJ, Hill MR, Briggs D, Pantelidis P, du Bois RM, Welsh KI, Evans TW (2008) Variation in iron homeostasis genes between patients with acute respiratory distress syndrome and healthy controls. Chest (in press)
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Metadata
Title
Haem oxygenase: A model for therapeutic intervention
Authors
Gregory J. Quinlan
Anna L. Lagan
Timothy W. Evans
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 4/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-008-1013-z

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