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01-05-2008 | Brief Report

Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis

Authors: Jimmy F. P. Berbée, Caroline C. van der Hoogt, Carla J. C. de Haas, Kok P. M. van Kessel, Geesje M. Dallinga-Thie, Johannes A. Romijn, Louis M. Havekes, Henk J. van Leeuwen, Patrick C. N. Rensen

Published in: Intensive Care Medicine | Issue 5/2008

Abstract

Objective

We recently reported that apolipoprotein CI (apoCI) protects against the development of murine bacterial sepsis. We now examined the time course of plasma apoCI levels in survivors and non-survivors of severe sepsis.

Design

Prospective study in patients meeting predefined criteria for severe sepsis.

Setting

University hospital intensive care unit.

Patients and participants

Seventeen patients with severe sepsis.

Interventions

In each patient, serial blood samples for determination of total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apoCI, apoAI, apoB, and apoCIII protein as well as clinical outcome data were collected over 30 days.

Measurements and results

Upon hospitalization, apoCI levels were approximately 5 times lower than normal values in septic patients, i.e. median 1.34 [interquartile range (IQR) 0.82–2.16] mg/dl. ApoCI gradually increased to median values of 5.51 (IQR 3.64–6.97) mg/dl on day 28. At day 0, apoCI levels tended to be lower in non-survivors than in survivors. Remarkably, apoCI levels remained low in non-survivors, whereas apoCI levels gradually increased to normal levels in survivors. This difference was significant and remained so after adjustment for lipoprotein core lipids. No such effect between survivors and non-survivors could be detected for lipoprotein lipids or for apoAI, apoB, and apoCIII after lipid adjustment.

Conclusions

Plasma apoCI levels are markedly decreased in patients with severe sepsis. ApoCI levels were higher in survivors, even after adjustment for lipid levels, and recovered progressively to normal levels. In contrast, apoCI levels remained low in non-survivors. Therefore, a high plasma apoCI level predicts survival in patients with severe sepsis.

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Title: Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis
Authors: Jimmy F. P. Berbée
Caroline C. van der Hoogt
Carla J. C. de Haas
Kok P. M. van Kessel
Geesje M. Dallinga-Thie
Johannes A. Romijn
Louis M. Havekes
Henk J. van Leeuwen
Patrick C. N. Rensen
Publication date: 01-05-2008
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 5/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1006-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis

Abstract

Objective

Design

Setting

Patients and participants

Interventions

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patients and participants

Interventions

Measurements and results

Conclusions

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