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Intensive Care Medicine
Published in: Intensive Care Medicine 9/2007

01-09-2007 | Editorial

Acute kidney injury in sepsis: Is renal blood flow more than just an innocent bystander?

Authors: Martin Matejovic, Peter Radermacher, Michael Joannidis

Published in: Intensive Care Medicine | Issue 9/2007

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Excerpt

Sir, The kidney is a common “victim organ” of various insults in critically ill patients, and, conversely, renal dysfunction adds substantially to the morbidity and mortality of these patients [1, 2]. Even relatively minor increments in serum creatinine levels coincide with markedly increased morbidity and mortality [3], highlighting the potentially important role of the kidney dysfunction during the natural history of critical illness. Sepsis and septic shock are the dominant cause of acute kidney injury (AKI), accounting for nearly 50% of episodes of acute renal failure [4]. Nevertheless, the exact understanding of pathophysiologic mechanisms of sepsis-induced AKI that would allow the development of new therapeutic strategies to prevent AKI or to hasten its recovery still remains a mystery. …
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Metadata
Title
Acute kidney injury in sepsis: Is renal blood flow more than just an innocent bystander?
Authors
Martin Matejovic
Peter Radermacher
Michael Joannidis
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 9/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0735-7

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