Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Intensive Care Medicine
Published in: Intensive Care Medicine 5/2007

01-05-2007 | Original

Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects

Authors: Thomas-Thi Pluess, Daniel Hayoz, Mette M. Berger, Luc Tappy, Jean-Pierre Revelly, Burkhard Michaeli, Yvon A. Carpentier, René L. Chioléro

Published in: Intensive Care Medicine | Issue 5/2007

Login to get access

Abstract

Objective

To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers.

Design

Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. The FO group received twice 0.5 g/kg 10% emulsion (Omegaven) 48 and 24 h before investigation. LPS (2 ng/kg) was injected as a bolus on the investigation day. Systemic parameters, indirect calorimetry, heart rate variability, and platelet membrane phospholipid composition were measured.

Results

Basal EPA and DHA content in platelet phospholipids was low (0.28% and 2.54%, respectively) and increased significantly after FO to 1.68% and 3.32%. LPS induced reproducible effects in all subjects. Fever was higher in the FO group than in controls; the difference was significant from t 120 until t 360. FO blunted the neuroendocrine response: the rise in plasma norepinephrine was sevenfold lower at t 120 while the ACTH peak was fourfold lower. Tumor necrosis factor α was significantly lower between t 360 and t 180 in the FO group.

Conclusions

Two doses of intravenous FO fat emulsion modified the phospholipid composition of platelets in healthy subjects. FO blunted fever and increased the neuroendocrine and the inflammatory responses to LPS.
Literature
1.
Calder PC (2004) n-3 fatty acids, inflammation, and immunity-relevance to postsurgical and critically ill patients. Lipids 39:1147–1161CrossRefPubMed
2.
Mayer K, Gokorsch S, Fegbeutel C, Hattar K, Rosseau S, Walmrath D, Seeger W, Grimminger F (2003) Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Respir Crit Care Med 167:1321–1328CrossRefPubMed
3.
Calder PC (2006) Use of fish oil in parenteral nutrition: rationale and reality. Proc Nutr Soc 65:264–277CrossRefPubMed
4.
Heller AR, Rossler S, Litz RJ, Stehr SN, Heller SC, Koch R, Koch T (2006) Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med 34:972–979CrossRefPubMed
5.
Livesey G, Elia M (1988) Estimation of energy expenditure, net carbohydrate utilization, and net fat oxydation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed composition of fuels. Am J Clin Nutr 47:608–628CrossRefPubMed
6.
Parati G, Di Rienzo M, Bertinieri G, Pomidossi G, Casadei R, Groppelli A, Pedotti A, Zanchetti A, Mancia G (1988) Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans. Hypertension 12:214–222CrossRefPubMed
7.
Bertinieri G, Di Rienzo M, Cavallazzi A, Ferrari A. U, Pedotti A, Mancia G (1988) Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats. Am J Physiol 254:H377–H383PubMed
8.
Lin E, Lowry SF (1998) The human response to endotoxin. Sepsis 2:255–262CrossRef
9.
Van der Poll T, Romijn JA, Endert E, Born JJJ, Büller HR, Sauerwein HP (1991) Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. Am J Physiol 261:H457–H465
10.
Spinas GA, Keller U, Brockhaus M (1992) Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia. J Clin Invest 90:533–536CrossRefPubMedPubMedCentral
11.
Bloesch D, Keller U, Spinas GA, Kury D, Girard J, Stauffacher W (1993) Effects of endotoxin on leucine and glucose kinetics in man: contribution of prostaglandin E2 assessed by a cyclooxygenase inhibitor. J Clin Endocrinol Metab 77:1156–1163PubMed
12.
Schmidt H, Muller-Werdan U, Hoffmann T, Francis DP, Piepoli MF, Rauchhaus M, Prondzinsky R, Loppnow H, Buerke M, Hoyer D, Werdan K (2005) Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups. Crit Care Med 33:1994–2002CrossRefPubMed
13.
Chiolero R, Kinney JM (2001) Metabolic and nutritional support in critically ill patients: feeding the whole body or individual organs? Curr Opin Clin Nutr Metab Care 4:127–130CrossRefPubMed
14.
Mascioli E, Leader L, Flores E, Trimbo S, Bistrian B, Blackburn G (1988) Enhanced survival to endotoxin in guinea pigs fed IV fish oil emulsion. Lipids 23:623–625CrossRefPubMed
15.
Pscheidl E, Schywalsky M, Tschaikowsky K, Böke-Pröls T (2000) Fish oil-supplemented parenteral diets normalize splanchnic blood flow and improve killing of translocated bacteria in a low-dose endotoxin rat model. Crit Care Med 28:1489–1496CrossRefPubMed
16.
Ellis EF, Police RJ, Dodson LY, McKinney JS, Holt SA (1992) Effect of dietary n-3 fatty acids on cerebral microcirculation. Am J Physiol 262:H1379–H1386PubMed
17.
Pomposelli JJ, Flores E, Hirschberg Y, Teo TC, Blackburn GL, Zeisel SH, Bistrian BR (1990) Short-term TPN containing n-3 fatty acids ameliorate lactic acidosis induced by endotoxin in guinea pigs. Am J Clin Nutr 52:548–552CrossRefPubMed
18.
Pomposelli JJ, Mascioli EA, Bistrian BR, Lopes SM, Blackburn GL (1989) Attenuation of the febrile response in guinea pigs by fish oil enriched diets. JPEN J Parenter Enteral Nutr 13:136–140CrossRefPubMed
19.
Teo TC, Selleck KM, Wan JM, Pomposelli JJ, Babayan VK, Blackburn GL, Bistrian BR (1991) Long-term feeding with structured lipid composed of medium-chain and N-3 fatty acids ameliorates endotoxic shock in guinea pigs. Metabolism 40:1152–1159CrossRefPubMed
20.
Michaeli B, Berger MM, Revelly JP, Tappy L, Chiolero R (2007) Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers. Clin Nutr 26:70–77CrossRefPubMed
21.
Weiss G, Meyer F, Matthies B, Pross M, Koenig W, Lippert H (2002) Immunomodulation by perioperative administration of n-3 fatty acids. Br J Nutr 87 Suppl 1:S89–S94
22.
Assenmacher I, Barbanel G, Gaillet S, Givalois L, Ixart G, Malaval F, Mekaouche M, Siaud P, Szafarczyk A (1995) Central regulation of ACTH release in stress. Ann N Y Acad Sci 771:41–54CrossRefPubMed
23.
Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351–1362CrossRefPubMed
24.
Delarue J, Matzinger O, Binnert C, Schneiter P, Chiolero R, Tappy L (2003) Fish-oil prevents the adrenal activation elicited by mental stress in healthy men. Diabet Med 29:289–295
25.
Copper AL, Gibbons L, Horan MA, Little RA, Rothwell NJ (1993) Effect of dietary fish oil supplementation on fever and cytokine production in human volunteers. Clin Nutr 12:3212–3328
26.
Lee JY, Plakidas A, Lee WH, Heikkinen A, Chanmugam P, Bray G, Hwang DH (2003) Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res 44:479–486CrossRefPubMed
27.
Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, van der Meer JW, Cannon JG, Rogers TS, Klempner MS, Weber PC et al (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320:265–271CrossRefPubMed
28.
Wachtler P, Konig W, Senkal M, Kemen M, Koller M (1997) Influence of a total parenteral nutrition enriched with omega-3 fatty acids on leukotriene synthesis of peripheral leukocytes and systemic cytokine levels in patients with major surgery. J Trauma 42:191–198CrossRefPubMed
29.
Carpentier YA, Dupont IE (2002) Optimizing intravenous supply of functional lipid components. Nestle Nutr Workshop Ser Clin Perform Programme 7:87–98CrossRefPubMed
30.
Harris HW, Johnson JA, Wigmore SJ (2002) Endogenous lipoproteins impact the response to endotoxin in humans. Crit Care Med 30:23–31CrossRefPubMed
31.
Feingold KR, Funk JL, Moser AH, Shigenaga JK, Rapp JH, Grunfeld C (1995) Role for circulating lipoproteins in protection from endotoxin toxicity. Infect Immun 63:2041–2046PubMedPubMedCentral
Metadata
Title
Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects
Authors
Thomas-Thi Pluess
Daniel Hayoz
Mette M. Berger
Luc Tappy
Jean-Pierre Revelly
Burkhard Michaeli
Yvon A. Carpentier
René L. Chioléro
Publication date
01-05-2007
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 5/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0591-5

Other articles of this Issue 5/2007

Intensive Care Medicine 5/2007 Go to the issue

Brief Report

Global cerebral blood flow and CPP after severe head injury: a xenon-CT study

Brief Report

The effect of exogenous surfactant in patients with lung contusions and acute lung injury

Editorial

Targeting caspase-1 in sepsis: a novel approach to an old problem

Experimental

Glycogen synthase kinase-3β inhibition attenuates the development of ischaemia/reperfusion injury of the gut

Correspondence

Entropy and bispectral index in brain-dead organ donors: authors' reply

Original

Failure to achieve glycemic control despite intensive insulin therapy in a medical ICU: incidence and influence on ICU mortality