Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Intensive Care Medicine
Published in: Intensive Care Medicine 2/2007

01-02-2007 | EXPERIMENTAL

Effects of vaporized perfluorohexane and partial liquid ventilation on regional distribution of alveolar damage in experimental lung injury

Authors: Peter M. Spieth, Lilla Knels, Michael Kasper, André Domingues Quelhas, Bärbel Wiedemann, Amelie Lupp, Matthias Hübler, Antonio Gianella Neto, Thea Koch, Marcelo Gama de Abreu

Published in: Intensive Care Medicine | Issue 2/2007

Login to get access

Abstract

Objective

To determine whether the patterns of distribution of histological effects of vaporized perfluorohexane (PFH) and partial liquid ventilation (PLV) differ significantly in acute lung injury.

Design and setting

Experimental study in an animal research laboratory.

Subjects

Eighteen pigs.

Interventions

After induction of acute lung injury by means of infusion of oleic acid animals were randomly assigned to PFH, PLV, or gas ventilation (GV) groups. Six hours thereafter animals were killed, and lung tissue samples were taken for analysis.

Measurements and results

Histopathological analysis revealed less damage with PFH than with GV or PLV in the nondependent and central regions. PFH and PLV showed less injury in the dependent regions than GV. GV and PFH were associated with less histological damage in the nondependent than the dependent regions, whereas PLV presented the opposite pattern. Morphometric analysis showed increased aeration in nondependent than dependent regions with PFH and GV. PLV led to more aeration in the periphery than in central areas.

Conclusions

PFH was associated with a more homogeneous attenuation of alveolar damage across the lungs, although this therapy had more pronounced effects in nondependent zones. PLV showed the opposite pattern, with more important reduction in alveolar damage in dependent lung regions. Interestingly, reduction in alveolar damage with PFH was as effective as with PLV in dependent zones. Our findings suggest that vaporized perfluorocarbon could be advantageous as adjunctive therapy in the treatment of acute lung injury.
Appendix
Available only for authorised users
Literature
1.
Hirschl RB, Pranikoff T, Gauger P, Schreiner RJ, Dechert R, Bartlett RH (1995) Liquid ventilation in adults, children, and full-term neonates. Lancet 346:1201–1202PubMedCrossRef
2.
Hirschl RB, Croce M, Gore D, Wiedemann H, Davis K, Zwischenberger J, Bartlett RH (2002) Prospective, randomized, controlled pilot study of partial liquid ventilation in adult acute respiratory distress syndrome. Am J Respir Crit Care Med 165:781–787PubMed
3.
Kacmarek RM, Wiedemann HP, Lavin PT, Wedel MK, Tutuncu AS, Slutsky AS (2006) Partial liquid ventilation in adult patients with the acute respiratory distress syndrome. Am J Respir Crit Care Med 173:882–889PubMedCrossRef
4.
Bleyl JU, Ragaller M, Tscho U, Regner M, Kanzow M, Hubler M, Rasche S, Albrecht M (1999) Vaporized perfluorocarbon improves oxygenation and pulmonary function in an ovine model of acute respiratory distress syndrome. Anesthesiology 91:461–469PubMedCrossRef
5.
Ragaller M, Bleyl J, Tscho U, Winkler T, Regner M, Rasche S, Koch T, Albrecht M (2001) Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury. Intensive Care Med 27:889–897PubMedCrossRef
6.
Kelly KP, Stenson BJ, Drummond GB (2000) Randomised comparison of partial liquid ventilation, nebulised perfluorocarbon, porcine surfactant, artificial surfactant, and combined treatments on oxygenation, lung mechanics, and survival in rabbits after saline lung lavage. Intensive Care Med 26:1523–1530PubMedCrossRef
7.
Gama de Abreu M, Quelhas AD, Spieth P, Brauer G, Knels L, Kasper M, Pino AV, Bleyl JU, Hubler M, Bozza F, Salluh J, Kuhlisch E, Giannella-Neto A, Koch T (2006) Comparative effects of vaporized perfluorohexane and partial liquid ventilation in oleic acid-induced lung injury. Anesthesiology 104:278–289PubMedCrossRef
8.
Spieth PM, Knels L, Kasper M, Bräuer G, Quelhas AD, Bleyl J-U, Hübler M, Koch T, Gianella-Neto A, Gama de Abreu M (2005) Effects of liquid and vaporized perfluorocarbons on histological correlates in oleic acid induced lung injury. Proc Am Thorac Soc 2:A147CrossRef
9.
Fujino Y, Goddon S, Chiche JD, Hromi J, Kacmarek RM (2000) Partial liquid ventilation ventilates better than gas ventilation. Am J Respir Crit Care Med 162:650–657PubMed
10.
Pakulla MA, Seidel D, Obal D, Loer SA (2004) Hydrochloric acid-induced lung injury: effects of early partial liquid ventilation on survival rate, gas exchange, and pulmonary neutrophil accumulation. Intensive Care Med 30:2110–2119PubMedCrossRef
11.
Koch T, Ragaller M, Haufe D, Hofer A, Grosser M, Albrecht DM, Kotzsch M, Luther T (2001) Perfluorohexane attenuates proinflammatory and procoagulatory response of activated monocytes and alveolar macrophages. Anesthesiology 94:101–109PubMedCrossRef
12.
Cox PN, Frndova H, Karlsson O, Holowka S, Bryan CA (2003) Fluorocarbons facilitate lung recruitment. Intensive Care Med 29:2297–2302PubMedCrossRef
13.
Morris KP, Cox PN, Mazer CD, Frndova H, McKerlie C, Wolfe R (2000) Distribution of pulmonary blood flow in the perfluorocarbon-filled lung. Intensive Care Med 26:756–763PubMedCrossRef
14.
Kemming GI, Flondor M, Hanser A, Pallivathukal S, Holtmannspotter M, Kneisel FF, Reuter DA, Kisch-Wedel H, Zwissler B (2005) Effects of perfluorohexan vapor on gas exchange, respiratory mechanics, and lung histology in pigs with lung injury after endotoxin infusion. Anesthesiology 103:585–594PubMedCrossRef
15.
Rudiger S, Gross U, Kemnitz E (2000) Perfluorocarbons useful tools for medicine. Eur J Med Res 5:209–216PubMed
16.
Shashikant BN, Miller TL, Jeng MJ, Davis J, Shaffer TH, Wolfson MR (2005) Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury. Crit Care Med 33:1096–1103PubMedCrossRef
Metadata
Title
Effects of vaporized perfluorohexane and partial liquid ventilation on regional distribution of alveolar damage in experimental lung injury
Authors
Peter M. Spieth
Lilla Knels
Michael Kasper
André Domingues Quelhas
Bärbel Wiedemann
Amelie Lupp
Matthias Hübler
Antonio Gianella Neto
Thea Koch
Marcelo Gama de Abreu
Publication date
01-02-2007
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 2/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-006-0428-7

Other articles of this Issue 2/2007

Intensive Care Medicine 2/2007 Go to the issue

Correspondence

Comment on Aboab et al.: Relation between PaO2/FiO2 ratio and FiO2: a mathematical description

Review

Posterior reversible encephalopathy syndrome in intensive care medicine

Editorial

Invasive devices: no need? No use!

Case Discussion

Acute respiratory distress and hemorrhagic shock in a patient 12 days after elective hepatic surgery

Original

The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial

Pediatric Original

Airway humidification with a heat and moisture exchanger in mechanically ventilated neonates