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Intensive Care Medicine
Published in: Intensive Care Medicine 9/2006

01-09-2006 | Original

Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock

Authors: Marjut Varpula, Sari Karlsson, Esko Ruokonen, Ville Pettilä

Published in: Intensive Care Medicine | Issue 9/2006

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Abstract

Objective

Central venous oxygen saturation (ScvO2) in initial resuscitation is included in the Surviving Sepsis Campaign guidelines. ScvO2 monitoring has also been suggested to be comparable to mixed venous oxygen saturation (SvO2) for clinical purposes. The aim of our study was to assess the correlation and agreement of ScvO2 and SvO2 and compare ScvO2–SvO2 difference to lactate, oxygen-derived and hemodynamic parameters in early septic shock in ICU after initial resuscitation.

Design and setting

Prospective clinical study with 16 patients with septic shock at two university hospital ICUs. A dose of norepinephrine over 0.1 μg/kg/min was required for inclusion.

Measurements and results

Five paired ScvO2 and SvO2 samples at 6-h intervals, altogether 72 samples, were collected during 24 h. The mean SvO2 was below the mean ScvO2 at all time points. Bias of difference was 4.2% and 95% limits of agreement ranged from –8.1% to 16.5%. The difference correlated significantly to CI and DO2.

Conclusions

The difference between paired ScvO2 and SvO2 varies highly. Therefore, SvO2 may not be estimated on the basis of ScvO2 in treatment of septic shock after resuscitation period in ICU.
Appendix
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Metadata
Title
Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock
Authors
Marjut Varpula
Sari Karlsson
Esko Ruokonen
Ville Pettilä
Publication date
01-09-2006
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 9/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-006-0270-y

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