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Intensive Care Medicine
Published in: Intensive Care Medicine 12/2005

01-12-2005 | Original

Static pressure volume curves and body posture in acute respiratory failure

Authors: Spyros D. Mentzelopoulos, Charis Roussos, Spyros G. Zakynthinos

Published in: Intensive Care Medicine | Issue 12/2005

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Abstract

Objective

In acute respiratory distress syndrome the body posture effects on pressure-volume (PV) curves are still unclear. We examined the effects of prone position on inflation PV curves and their potential relationships with postural alterations in gas exchange.

Design and setting

Prospective study with patients serving as their own controls in a university-affiliated 30-bed intensive care unit.

Patients and participants

Thirteen anesthetized, paralyzed, semirecumbent, mechanically ventilated patients with early/severe/diffuse ARDS.

Interventions

Sequential body posture changes: preprone semirecumbent, prone, and postprone semirecumbent.

Measurements and results

In each posture hemodynamics, gas exchange, and lung volumes were determined before/during removal and after restoration of positive end-expiratory pressure (PEEP=10.2±0.6 cmH2O). At zero PEEP PV curves of respiratory system, lung, and chest wall were constructed. Prone position vs. preprone semirecumbent resulted in significantly reduced pressure at lower inflection point of lung PV curve (2.2±0.2 vs. 3.7±0.5 cmH2O) and increased volume at upper inflection point (0.87±0.03 vs. 0.69±0.05 l). Postural reduction in lower inflection point pressure of lung PV curve was the sole independent predictor of pronation-induced increases in PaO2/FIO2 (R2=0.76). PaO2/FIO2 increases were also significantly related with increases in functional residual capacity (R2=0.60).

Conclusions

In early/severe/diffuse ARDS prone position reduces lower inflection point pressure and increases upper inflection point UIP volume of the lung PV curve. Lower inflection point pressure reductions explain oxygenation improvements, which are also associated with a postural increase in functional residual capacity.
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Metadata
Title
Static pressure volume curves and body posture in acute respiratory failure
Authors
Spyros D. Mentzelopoulos
Charis Roussos
Spyros G. Zakynthinos
Publication date
01-12-2005
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 12/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-005-2838-3

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