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Intensive Care Medicine
Published in: Intensive Care Medicine 7/2004

01-07-2004 | Original

Fluid resuscitation with colloids of different molecular weight in septic shock

Authors: Zsolt Molnár, András Mikor, Tamás Leiner, Tamás Szakmány

Published in: Intensive Care Medicine | Issue 7/2004

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Abstract

Objective

The aim of this study was to investigate the short-term effect of fluid resuscitation with 4% modified fluid gelatine (GEL) versus 6% hydroxyethyl starch (HES) on haemodynamics and oxygenation in patients with septic shock and acute lung injury (ALI).

Design

Prospective randomised clinical trial.

Setting

Twenty-bed intensive care unit in a university hospital.

Patients

Thirty hypovolemic patients (intrathoracic blood volume index, ITBVI <850 ml/m2) in septic shock with ALI were randomised into HES (mean molecular weight: 200,000 Dalton, degree of substitution 0.6) and GEL (mean molecular weight: 30,000 Dalton) groups (15 patients each).

Interventions

For fluid resuscitation 250 ml/15 min boluses (max. 1,000 ml) were given until the end point of ITBVI >900 ml/m2 was reached. Repeated haemodynamic measurements were done at baseline (tb), at the end point (tep) then at 30 min and 60 min after the end point was reached (t30, t60). Cardiac output, stroke volume, extravascular lung water (EVLW), and oxygen delivery was determined at each assessment point. For statistical analysis two-way ANOVA was used.

Measurements and results

ITBVI, cardiac index, and oxygen delivery index increased significantly at tep and remained elevated for t30 and t60, but there was no significant difference between the two groups. The increase in the ITBVI by 100 ml of infusion was similar in both groups (HES: 26±19 ml/m2 vs GEL: 30±19 ml/m2). EVLW, remained unchanged, and there was no significant difference between the groups (HES, tb: 8±6, t60: 8±6; GEL, tb: 8±3, t60: 8±3 ml/kg). The PaO2/FiO2 did not change significantly over time or between groups (HES, tb: 207±114, t60: 189±78; GEL, tb: 182±85, t60: 182±85 mmHg).

Conclusion

The results of this study indicate that both HES and GEL infusions caused similar short-term change in ITBVI in septic shock, without increasing EVLW or worsening oxygenation.
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Metadata
Title
Fluid resuscitation with colloids of different molecular weight in septic shock
Authors
Zsolt Molnár
András Mikor
Tamás Leiner
Tamás Szakmány
Publication date
01-07-2004
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 7/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-004-2278-5

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