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Intensive Care Medicine
Published in: Intensive Care Medicine 6/2004

01-06-2004 | Brief Report

Thrombotic microangiopathy: an atypical cause of acute renal failure in patients with acute pancreatitis

Authors: Alexandre Boyer, Karim Chadda, Amar Salah, Guy Bonmarchand

Published in: Intensive Care Medicine | Issue 6/2004

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Abstract

Objective

To report on the development and treatment of thrombotic microangiopathy, an atypical cause of acute renal failure in patients with acute pancreatitis.

Design

Case reports.

Setting

A 21-bed medical intensive care unit at an university hospital.

Patients

Two men with acute pancreatitis presented with acute renal failure, neurological manifestations, haemolytic anaemia and thrombocytopenia. Both patients required intensive care.

Measurements

Fragmented red cell count; levels of haptoglobin, amylase and lipase; serological testing for Escherichia Coli O157; computed tomography of the abdomen.

Main results

The patients’ courses were rapidly favourable after daily plasma exchange. A review of the existing medical literature was also undertaken.

Conclusion

As thrombotic microangiopathy may be life-threatening without administration of fresh frozen plasma or plasma exchange, physicians should consider this disease as a possible cause of acute renal failure in patients with acute pancreatitis.
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Metadata
Title
Thrombotic microangiopathy: an atypical cause of acute renal failure in patients with acute pancreatitis
Authors
Alexandre Boyer
Karim Chadda
Amar Salah
Guy Bonmarchand
Publication date
01-06-2004
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 6/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-004-2272-y

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