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01-04-2004 | Special Article

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

Authors: R. Phillip Dellinger, Jean M. Carlet, Henry Masur, Herwig Gerlach, Thierry Calandra, Jonathan Cohen, Juan Gea-Banacloche, Didier Keh, John C. Marshall, Margaret M. Parker, Graham Ramsay, Janice L. Zimmerman, Jean-Louis Vincent, M. M. Levy

Published in: Intensive Care Medicine | Issue 4/2004

Abstract

Objective

To develop management guidelines for severe sepsis and septic shock that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an international effort to increase awareness and improve outcome in severe sepsis.

Design

The process included a modified Delphi method, a consensus conference, several subsequent smaller meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. The modified Delphi methodology used for grading recommendations built upon a 2001 publication sponsored by the International Sepsis Forum. We undertook a systematic review of the literature graded along 5 levels to create recommendation grades from A–E, with A being the highest grade. Pediatric considerations were provided to contrast adult and pediatric management.

Participants

Participants included 44 critical care and infectious disease experts representing 11 international organizations.

Results

A total of 46 recommendations plus pediatric management considerations.

Conclusions

Evidence-based recommendations can be made regarding many aspects of the acute management of sepsis and septic shock that will hopefully translate into improved outcomes for the critically ill patient. The impact of these guidelines will be formally tested and guidelines updated annually, and even more rapidly when some important new knowledge becomes available.

Available only for authorised users

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Title: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Authors: R. Phillip Dellinger
Jean M. Carlet
Henry Masur
Herwig Gerlach
Thierry Calandra
Jonathan Cohen
Juan Gea-Banacloche
Didier Keh
John C. Marshall
Margaret M. Parker
Graham Ramsay
Janice L. Zimmerman
Jean-Louis Vincent
M. M. Levy
Publication date: 01-04-2004
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 4/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2210-z

At a glance: The STEP trials

Springer Medicine

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

Abstract

Objective

Design

Participants

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Design

Participants

Results

Conclusions

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