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Intensive Care Medicine
Published in: Intensive Care Medicine 6/2004

01-06-2004 | Original Article

A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient

Authors: Natasha Koroloff, Robert Boots, Jeff Lipman, Peter Thomas, Claire Rickard, Fiona Coyer

Published in: Intensive Care Medicine | Issue 6/2004

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Abstract

Objective

To compare the efficacy of two forms of eye care (hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.

Design

Randomised-controlled trial.

Setting

University affiliated, tertiary referral hospital.

Patients and participants

One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection.

Interventions

All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber.

Measurements and results

Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group.

Conclusions

Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
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Metadata
Title
A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Authors
Natasha Koroloff
Robert Boots
Jeff Lipman
Peter Thomas
Claire Rickard
Fiona Coyer
Publication date
01-06-2004
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 6/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-004-2203-y

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