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01-08-2003 | Brief Report

Plasma oxidative parameters and mortality in patients with severe burn injury

Authors: Cristiane Ritter, Michael Andrades, Márcio Guerreiro, Leonardo Zavaschi, Daniel Pens Gelain, Luis Fernando Souza, Cyntia A. Ribeiro, Nadine Clausell, Sérgio Menna-Barreto, José Cláudio F. Moreira, Felipe Dal-Pizzol

Published in: Intensive Care Medicine | Issue 8/2003

Abstract

Objective

To determine xanthine oxidase and superoxide dismutase activities, lipid peroxidation, protein carbonylation, and total radical-trapping antioxidant parameter in survivors and nonsurvivors patients with severe burn injury.

Design and setting

Prospective, comparative observational study in an intensive care unit, burn division, in a trauma hospital.

Patients

Twenty-five consecutive patients who met the established criteria for severe burn injury (total burn surface area of more than 30%).

Measurements and results

Plasma thiobarbituric acid reactive species and protein carbonyls levels were significantly higher in nonsurvivors than in survivors at 0 and 6 h. Elevated xanthine oxidase activity at 0 h was associated with adverse outcome after burn injury. In contrast, plasma superoxide dismutase activity and total radical-trapping antioxidant parameter did not differ significantly between nonsurvivors and survivors at any time point.

Conclusions

For the first time we demonstrate the value of oxidative parameters, namely thiobarbituric acid reactive species, protein carbonyls, and xanthine oxidase activity, in identifying burn patients with a poor prognosis. Whether these parameters are merely markers of clinical course, or whether they signal specific deleterious effects of oxidative stress during the burn injury remains to be elucidated.

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Title: Plasma oxidative parameters and mortality in patients with severe burn injury
Authors: Cristiane Ritter
Michael Andrades
Márcio Guerreiro
Leonardo Zavaschi
Daniel Pens Gelain
Luis Fernando Souza
Cyntia A. Ribeiro
Nadine Clausell
Sérgio Menna-Barreto
José Cláudio F. Moreira
Felipe Dal-Pizzol
Publication date: 01-08-2003
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 8/2003
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-003-1833-9

At a glance: The STEP trials

Springer Medicine

Plasma oxidative parameters and mortality in patients with severe burn injury

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

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