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Published in: Social Psychiatry and Psychiatric Epidemiology 5/2018

Open Access 01-05-2018 | Original Paper

Adverse life outcomes associated with adolescent psychotic experiences and depressive symptoms

Authors: Jonathan Davies, Sarah Sullivan, Stanley Zammit

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 5/2018

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Abstract

Purpose

To investigate whether psychotic experiences and depressive symptoms at ages 12 and 18 years are associated with adverse life outcomes across a range of functional domains between 16 and 20 years of age.

Methods

Data were gathered from ALSPAC, a UK birth cohort. Individuals were assessed with the semi-structured Psychosis-Like Symptoms Interview and the Short Mood and Feeling Questionnaire at ages 12 and 18 years. Logistic regression was used to explore associations with outcomes in education, occupation, social functioning, substance use (alcohol, cannabis, smoking, and other drugs), and illegal behaviour between the ages of 16 and 20 years. All associations were adjusted for socio-demographic and childhood confounders and for comorbid psychotic experiences or depressive symptoms.

Results

Psychotic experiences and depression at age 12 were associated with poorer educational, occupational, and social outcomes between the ages of 16 and 20; these withstood adjustment for confounding. Depressive symptoms at age 12 were also associated with harmful drinking. Psychotic experiences and depression at age 18 were additionally associated with other forms of substance use and illegal behaviour. Comorbidity had little impact at age 12, but was associated with significantly worse educational, social, and substance use outcomes at age 18.

Conclusions

Adolescent psychotic experiences and depression represent a risk marker for a number of later adverse outcomes, most consistently with education and employment, but also social impairment, harmful drinking, and substance use. This highlights the importance of recognizing adolescent psychopathology, so that support can be provided to try and minimize adverse outcomes.
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Literature
1.
go back to reference van Os J et al (2009) A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychol Med 39(2):179 – 95CrossRefPubMed van Os J et al (2009) A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychol Med 39(2):179 – 95CrossRefPubMed
2.
go back to reference Hankin BL et al (1998) Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. J Abnorm Psychol 107(1):128–140CrossRefPubMed Hankin BL et al (1998) Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. J Abnorm Psychol 107(1):128–140CrossRefPubMed
3.
go back to reference Kessler RC, Walters EE (1998) Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey. Depress Anxiety 7(1):3–14CrossRefPubMed Kessler RC, Walters EE (1998) Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey. Depress Anxiety 7(1):3–14CrossRefPubMed
4.
go back to reference Cheung AH, Dewa CS (2006) Canadian community health survey: major depressive disorder and suicidality in adolescents. Healthc Policy 2(2):76–89PubMedPubMedCentral Cheung AH, Dewa CS (2006) Canadian community health survey: major depressive disorder and suicidality in adolescents. Healthc Policy 2(2):76–89PubMedPubMedCentral
5.
6.
go back to reference Polanczyk G et al (2010) Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch Gen Psychiatry 67(4):328–338CrossRefPubMedPubMedCentral Polanczyk G et al (2010) Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch Gen Psychiatry 67(4):328–338CrossRefPubMedPubMedCentral
7.
go back to reference Zammit S et al (2013) Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study. Am J Psychiatry 170(7):742–750CrossRefPubMed Zammit S et al (2013) Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study. Am J Psychiatry 170(7):742–750CrossRefPubMed
8.
go back to reference Kelleher I et al (2012) Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies. Psychol Med 42(9):1857–1863CrossRefPubMed Kelleher I et al (2012) Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies. Psychol Med 42(9):1857–1863CrossRefPubMed
10.
go back to reference Fergusson DM, Woodward LJ (2002) Mental health, educational, and social role outcomes of adolescents with depression. Arch Gen Psychiatry 59(3):225–231CrossRefPubMed Fergusson DM, Woodward LJ (2002) Mental health, educational, and social role outcomes of adolescents with depression. Arch Gen Psychiatry 59(3):225–231CrossRefPubMed
11.
go back to reference McLeod GF, Horwood LJ, Fergusson DM (2016) Adolescent depression, adult mental health and psychosocial outcomes at 30 and 35 years. Psychol Med 46(7):1401–1412CrossRefPubMed McLeod GF, Horwood LJ, Fergusson DM (2016) Adolescent depression, adult mental health and psychosocial outcomes at 30 and 35 years. Psychol Med 46(7):1401–1412CrossRefPubMed
12.
go back to reference Poulton R et al (2000) Children’s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry 57(11):1053–1058CrossRefPubMed Poulton R et al (2000) Children’s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry 57(11):1053–1058CrossRefPubMed
13.
go back to reference Yung AR et al (2009) Psychotic-like experiences in a community sample of adolescents: implications for the continuum model of psychosis and prediction of schizophrenia. Aust N Z J Psychiatry 43(2):118–128CrossRefPubMed Yung AR et al (2009) Psychotic-like experiences in a community sample of adolescents: implications for the continuum model of psychosis and prediction of schizophrenia. Aust N Z J Psychiatry 43(2):118–128CrossRefPubMed
14.
go back to reference Kelleher I et al (2012) Psychotic symptoms in adolescence index risk for suicidal behavior: findings from 2 population-based case-control clinical interview studies. Arch Gen Psychiatry 69(12):1277–1283CrossRefPubMed Kelleher I et al (2012) Psychotic symptoms in adolescence index risk for suicidal behavior: findings from 2 population-based case-control clinical interview studies. Arch Gen Psychiatry 69(12):1277–1283CrossRefPubMed
15.
go back to reference Sullivan SA et al (2015) The longitudinal association between psychotic experiences, depression and suicidal behaviour in a population sample of adolescents. Soc Psychiatry Psychiatr Epidemiol 50(12):1809–1817CrossRefPubMedPubMedCentral Sullivan SA et al (2015) The longitudinal association between psychotic experiences, depression and suicidal behaviour in a population sample of adolescents. Soc Psychiatry Psychiatr Epidemiol 50(12):1809–1817CrossRefPubMedPubMedCentral
16.
go back to reference Kandel DB, Davies M (1986) Adult sequelae of adolescent depressive symptoms. Arch Gen Psychiatry 43(3):255–262CrossRefPubMed Kandel DB, Davies M (1986) Adult sequelae of adolescent depressive symptoms. Arch Gen Psychiatry 43(3):255–262CrossRefPubMed
17.
go back to reference Fergusson DM, Boden JM, Horwood LJ (2007) Recurrence of major depression in adolescence and early adulthood, and later mental health, educational and economic outcomes. Br J Psychiatry 191:335–342CrossRefPubMed Fergusson DM, Boden JM, Horwood LJ (2007) Recurrence of major depression in adolescence and early adulthood, and later mental health, educational and economic outcomes. Br J Psychiatry 191:335–342CrossRefPubMed
18.
go back to reference Marmorstein NR (2009) Longitudinal associations between alcohol problems and depressive symptoms: early adolescence through early adulthood. Alcohol Clin Exp Res 33(1):49–59CrossRefPubMed Marmorstein NR (2009) Longitudinal associations between alcohol problems and depressive symptoms: early adolescence through early adulthood. Alcohol Clin Exp Res 33(1):49–59CrossRefPubMed
19.
go back to reference Naicker K et al (2013) Social, demographic, and health outcomes in the 10 years following adolescent depression. J Adolesc Health 52(5):533–538CrossRefPubMed Naicker K et al (2013) Social, demographic, and health outcomes in the 10 years following adolescent depression. J Adolesc Health 52(5):533–538CrossRefPubMed
20.
go back to reference Kelleher I et al (2014) Psychotic experiences in a mental health clinic sample: implications for suicidality, multimorbidity and functioning. Psychol Med 44(8):1615–1624CrossRefPubMed Kelleher I et al (2014) Psychotic experiences in a mental health clinic sample: implications for suicidality, multimorbidity and functioning. Psychol Med 44(8):1615–1624CrossRefPubMed
21.
go back to reference Armando M et al (2010) Psychotic-like experiences and correlation with distress and depressive symptoms in a community sample of adolescents and young adults. Schizophr Res 119(1–3):258–265CrossRefPubMed Armando M et al (2010) Psychotic-like experiences and correlation with distress and depressive symptoms in a community sample of adolescents and young adults. Schizophr Res 119(1–3):258–265CrossRefPubMed
22.
go back to reference Kelleher I et al (2015) Psychotic experiences in the population: association with functioning and mental distress. Schizophr Res 165(1):9–14CrossRefPubMed Kelleher I et al (2015) Psychotic experiences in the population: association with functioning and mental distress. Schizophr Res 165(1):9–14CrossRefPubMed
23.
go back to reference Nishida A et al (2008) Associations between psychotic-like experiences and mental health status and other psychopathologies among Japanese early teens. Schizophr Res 99(1–3):125 – 33CrossRefPubMed Nishida A et al (2008) Associations between psychotic-like experiences and mental health status and other psychopathologies among Japanese early teens. Schizophr Res 99(1–3):125 – 33CrossRefPubMed
24.
go back to reference Dolphin L, Dooley B, Fitzgerald A (2015) Prevalence and correlates of psychotic like experiences in a nationally representative community sample of adolescents in Ireland. Schizophr Res 169(1–3):241–247CrossRefPubMed Dolphin L, Dooley B, Fitzgerald A (2015) Prevalence and correlates of psychotic like experiences in a nationally representative community sample of adolescents in Ireland. Schizophr Res 169(1–3):241–247CrossRefPubMed
25.
go back to reference Scott J et al (2009) The prevalence and correlates of hallucinations in Australian adolescents: results from a national survey. Schizophr Res 107(2–3):179 – 85CrossRefPubMed Scott J et al (2009) The prevalence and correlates of hallucinations in Australian adolescents: results from a national survey. Schizophr Res 107(2–3):179 – 85CrossRefPubMed
26.
go back to reference Rossler W et al (2007) Psychotic experiences in the general population: a twenty-year prospective community study. Schizophr Res 92(1–3):1–14CrossRefPubMed Rossler W et al (2007) Psychotic experiences in the general population: a twenty-year prospective community study. Schizophr Res 92(1–3):1–14CrossRefPubMed
27.
go back to reference Bartels-Velthuis AA et al (2010) Prevalence and correlates of auditory vocal hallucinations in middle childhood. Br J Psychiatry 196(1):41–46CrossRefPubMed Bartels-Velthuis AA et al (2010) Prevalence and correlates of auditory vocal hallucinations in middle childhood. Br J Psychiatry 196(1):41–46CrossRefPubMed
28.
go back to reference Bartels-Velthuis AA et al (2011) Course of auditory vocal hallucinations in childhood: 5-year follow-up study. Br J Psychiatry 199(4):296–302CrossRefPubMed Bartels-Velthuis AA et al (2011) Course of auditory vocal hallucinations in childhood: 5-year follow-up study. Br J Psychiatry 199(4):296–302CrossRefPubMed
29.
go back to reference Asher L et al (2013) The relationship between psychotic symptoms and social functioning in a non-clinical population of 12 year olds. Schizophr Res 150(2–3): 404–409CrossRefPubMed Asher L et al (2013) The relationship between psychotic symptoms and social functioning in a non-clinical population of 12 year olds. Schizophr Res 150(2–3): 404–409CrossRefPubMed
30.
go back to reference Kelleher I et al (2012) Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies. Br J Psychiatry 201(1):26–32CrossRefPubMed Kelleher I et al (2012) Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies. Br J Psychiatry 201(1):26–32CrossRefPubMed
31.
go back to reference Kounali D et al (2014) Common versus psychopathology-specific risk factors for psychotic experiences and depression during adolescence. Psychol Med 44(12):2557–2566CrossRefPubMedPubMedCentral Kounali D et al (2014) Common versus psychopathology-specific risk factors for psychotic experiences and depression during adolescence. Psychol Med 44(12):2557–2566CrossRefPubMedPubMedCentral
32.
go back to reference Stochl J et al (2015) Mood, anxiety and psychotic phenomena measure a common psychopathological factor. Psychol Med 45(7):1483–1493CrossRefPubMed Stochl J et al (2015) Mood, anxiety and psychotic phenomena measure a common psychopathological factor. Psychol Med 45(7):1483–1493CrossRefPubMed
33.
go back to reference Fisher HL et al (2013) Specificity of childhood psychotic symptoms for predicting schizophrenia by 38 years of age: a birth cohort study. Psychol Med 43(10):2077–2086CrossRefPubMedPubMedCentral Fisher HL et al (2013) Specificity of childhood psychotic symptoms for predicting schizophrenia by 38 years of age: a birth cohort study. Psychol Med 43(10):2077–2086CrossRefPubMedPubMedCentral
34.
go back to reference Boyd A et al (2013) Cohort Profile: the ‘children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol 42(1):111 – 27CrossRefPubMed Boyd A et al (2013) Cohort Profile: the ‘children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol 42(1):111 – 27CrossRefPubMed
35.
go back to reference Angold A et al (1995) Development of a short questionnaire for use in epidemiologyical studies of depression in children and adolescent. Int J Methods Psychiatr Res 5:237–249 Angold A et al (1995) Development of a short questionnaire for use in epidemiologyical studies of depression in children and adolescent. Int J Methods Psychiatr Res 5:237–249
36.
go back to reference Patton GC et al (2008) Predicting female depression across puberty: a two-nation longitudinal study. J Am Acad Child Adolesc Psychiatry 47(12):1424–1432CrossRefPubMedPubMedCentral Patton GC et al (2008) Predicting female depression across puberty: a two-nation longitudinal study. J Am Acad Child Adolesc Psychiatry 47(12):1424–1432CrossRefPubMedPubMedCentral
37.
go back to reference Office for National Statistics (2013) Young People Not in Education, Employment or Training (NEET). The Stationary Office, London Office for National Statistics (2013) Young People Not in Education, Employment or Training (NEET). The Stationary Office, London
38.
go back to reference Goodman R (1997) The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry 38(5):581–586CrossRefPubMed Goodman R (1997) The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry 38(5):581–586CrossRefPubMed
39.
go back to reference Meltzer H et al (2000) The mental health of children and adolescents in Great Britain. The Stationary Office, London, p 148 Meltzer H et al (2000) The mental health of children and adolescents in Great Britain. The Stationary Office, London, p 148
40.
go back to reference Saunders JB et al (1993) Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption–II. Addiction 88(6):791–804CrossRefPubMed Saunders JB et al (1993) Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption–II. Addiction 88(6):791–804CrossRefPubMed
41.
go back to reference Babor TF et al (2001) AUDIT: the alcohol use disorders identification test, guidelines for use in primary care, D.o.M.H.a.S. Dependence, Editor. 2001, World Health Organisation Babor TF et al (2001) AUDIT: the alcohol use disorders identification test, guidelines for use in primary care, D.o.M.H.a.S. Dependence, Editor. 2001, World Health Organisation
42.
go back to reference Legleye S et al (2013) A validation of the Cannabis Abuse Screening Test (CAST) using a latent class analysis of the DSM-IV among adolescents. Int J Methods Psychiatr Res 22(1):16–26CrossRefPubMed Legleye S et al (2013) A validation of the Cannabis Abuse Screening Test (CAST) using a latent class analysis of the DSM-IV among adolescents. Int J Methods Psychiatr Res 22(1):16–26CrossRefPubMed
43.
go back to reference Heron J et al (2013) Childhood conduct disorder trajectories, prior risk factors and cannabis use at age 16: birth cohort study. Addiction 108(12):2129–2138CrossRefPubMedPubMedCentral Heron J et al (2013) Childhood conduct disorder trajectories, prior risk factors and cannabis use at age 16: birth cohort study. Addiction 108(12):2129–2138CrossRefPubMedPubMedCentral
45.
46.
go back to reference National Institute for Health and Clinical Excellence (2013) Psychosis and schizophrenia in children and young people: recognition and management. NICE guideline (CG155) National Institute for Health and Clinical Excellence (2013) Psychosis and schizophrenia in children and young people: recognition and management. NICE guideline (CG155)
47.
go back to reference National Institute for Health and Clinical Excellence (2005) Depression in children and young people: identification and management., NICE guideline (CG28) National Institute for Health and Clinical Excellence (2005) Depression in children and young people: identification and management., NICE guideline (CG28)
Metadata
Title
Adverse life outcomes associated with adolescent psychotic experiences and depressive symptoms
Authors
Jonathan Davies
Sarah Sullivan
Stanley Zammit
Publication date
01-05-2018
Publisher
Springer Berlin Heidelberg
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 5/2018
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-018-1496-z

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