Skip to main content
Top
Published in: Social Psychiatry and Psychiatric Epidemiology 4/2016

Open Access 01-04-2016 | Study Protocols and Samples

Ethnicity and cardiovascular health inequalities in people with severe mental illnesses: protocol for the E-CHASM study

Authors: J. Das-Munshi, M. Ashworth, F. Gaughran, S. Hull, C. Morgan, J. Nazroo, A. Roberts, D. Rose, P. Schofield, R. Stewart, G. Thornicroft, M. J. Prince

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 4/2016

Login to get access

Abstract

Purpose

People with severe mental illnesses (SMI) experience a 17- to 20-year reduction in life expectancy. One-third of deaths are due to cardiovascular disease. This study will establish the relationship of SMI with cardiovascular disease in ethnic minority groups (Indian, Pakistani, Bangladeshi, black Caribbean, black African and Irish), in the UK.

Methods

E-CHASM is a mixed methods study utilising data from 1.25 million electronic patient records. Secondary analysis of routine patient records will establish if differences in cause-specific mortality, cardiovascular disease prevalence and disparities in accessing healthcare for ethnic minority people living with SMI exist. A nested qualitative study will be used to assess barriers to accessing healthcare, both from the perspectives of service users and providers.

Results

In primary care, 993,116 individuals, aged 18+, provided data from 186/189 (98 %) practices in four inner-city boroughs (local government areas) in London. Prevalence of SMI according to primary care records, ranged from 1.3–1.7 %, across boroughs. The primary care sample included Bangladeshi [n = 94,643 (10 %)], Indian [n = 6086 (6 %)], Pakistani [n = 35,596 (4 %)], black Caribbean [n = 45,013 (5 %)], black African [n = 75,454 (8 %)] and Irish people [n = 13,745 (1 %)]. In the secondary care database, 12,432 individuals with SMI over 2007–2013 contributed information; prevalent diagnoses were schizophrenia [n = 6805 (55 %)], schizoaffective disorders [n = 1438 (12 %)] and bipolar affective disorder [n = 4112 (33 %)]. Largest ethnic minority groups in this sample were black Caribbean [1432 (12 %)] and black African (1393 (11 %)).

Conclusions

There is a dearth of research examining cardiovascular disease in minority ethnic groups with severe mental illnesses. The E-CHASM study will address this knowledge gap.
Literature
1.
go back to reference Chang C-K et al (2011) Life expectancy at birth for people with serious mental illness and other major disorders from a Secondary Mental Health Care Case Register in London. PLoS One 6(5):e19590CrossRefPubMedPubMedCentral Chang C-K et al (2011) Life expectancy at birth for people with serious mental illness and other major disorders from a Secondary Mental Health Care Case Register in London. PLoS One 6(5):e19590CrossRefPubMedPubMedCentral
2.
go back to reference Wahlbeck K et al (2011) Outcomes of nordic mental health systems: life expectancy of patients with mental disorders. Br J Psychiatry 199(6):453–458CrossRefPubMed Wahlbeck K et al (2011) Outcomes of nordic mental health systems: life expectancy of patients with mental disorders. Br J Psychiatry 199(6):453–458CrossRefPubMed
3.
go back to reference Lawrence D, Hancock KJ, Kisely S (2013) The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers. BMJ 346:f2539CrossRefPubMedPubMedCentral Lawrence D, Hancock KJ, Kisely S (2013) The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers. BMJ 346:f2539CrossRefPubMedPubMedCentral
4.
go back to reference Desai M et al (2002) Mental disorders and quality of diabetes care in the veterans health administration. Am J Psychiatry 159:1584–1590CrossRefPubMed Desai M et al (2002) Mental disorders and quality of diabetes care in the veterans health administration. Am J Psychiatry 159:1584–1590CrossRefPubMed
5.
go back to reference Daumit G et al (2006) Adverse events during medical and surgical hospitalizations for persons with schizophrenia. Arch Gen Psychiatry 63:267–272CrossRefPubMed Daumit G et al (2006) Adverse events during medical and surgical hospitalizations for persons with schizophrenia. Arch Gen Psychiatry 63:267–272CrossRefPubMed
6.
go back to reference Lawrence DM et al (2003) Death rate from ischaemic heart disease in Western Australian psychiatric patients 1980–1998. Br J Psychiatry 182(1):31–36CrossRefPubMed Lawrence DM et al (2003) Death rate from ischaemic heart disease in Western Australian psychiatric patients 1980–1998. Br J Psychiatry 182(1):31–36CrossRefPubMed
7.
go back to reference Taylor DM, McAskill R (2000) Atypical antipsychotics and weight gain—a systematic review. Acta Psychiatr Scand 101(6):416–432CrossRefPubMed Taylor DM, McAskill R (2000) Atypical antipsychotics and weight gain—a systematic review. Acta Psychiatr Scand 101(6):416–432CrossRefPubMed
8.
go back to reference Rummel-Kluge C et al (2010) Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res 123(2–3):225–233CrossRefPubMedPubMedCentral Rummel-Kluge C et al (2010) Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res 123(2–3):225–233CrossRefPubMedPubMedCentral
9.
go back to reference Smith M et al (2008) First-v. second-generation antipsychotics and risk for diabetes in schizophrenia: systematic review and meta-analysis. Br J Psychiatry 192(6):406–411CrossRefPubMed Smith M et al (2008) First-v. second-generation antipsychotics and risk for diabetes in schizophrenia: systematic review and meta-analysis. Br J Psychiatry 192(6):406–411CrossRefPubMed
10.
go back to reference de Leon J, Diaz FJ (2005) A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors. Schizophr Res 76(2–3):135–157CrossRefPubMed de Leon J, Diaz FJ (2005) A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors. Schizophr Res 76(2–3):135–157CrossRefPubMed
11.
go back to reference Osborn DJ et al (2007) Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom’s General Practice Research Database. Arch Gen Psychiatry 64(2):242–249CrossRefPubMed Osborn DJ et al (2007) Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom’s General Practice Research Database. Arch Gen Psychiatry 64(2):242–249CrossRefPubMed
13.
go back to reference Chang C-K et al (2010) All-cause mortality among people with serious mental illness (SMI), substance use disorders, and depressive disorders in southeast London: a cohort study. BMC Psychiatry 10(1):77CrossRefPubMedPubMedCentral Chang C-K et al (2010) All-cause mortality among people with serious mental illness (SMI), substance use disorders, and depressive disorders in southeast London: a cohort study. BMC Psychiatry 10(1):77CrossRefPubMedPubMedCentral
14.
go back to reference Carliner H et al (2014) Prevalence of cardiovascular risk factors among racial and ethnic minorities with schizophrenia spectrum and bipolar disorders: a critical literature review. Compr Psychiatry 55(2):233–247CrossRefPubMedPubMedCentral Carliner H et al (2014) Prevalence of cardiovascular risk factors among racial and ethnic minorities with schizophrenia spectrum and bipolar disorders: a critical literature review. Compr Psychiatry 55(2):233–247CrossRefPubMedPubMedCentral
15.
go back to reference Bhui K et al (2003) Ethnic variations in pathways to and use of specialist mental health services in the UK: systematic review. Br J Psychiatry 182(2):105–116CrossRefPubMed Bhui K et al (2003) Ethnic variations in pathways to and use of specialist mental health services in the UK: systematic review. Br J Psychiatry 182(2):105–116CrossRefPubMed
16.
go back to reference Boydell J et al (2012) Satisfaction with inpatient treatment for first-episode psychosis among different ethnic groups: a report from the UK AESOP study. Int J Soc Psychiatry 58(1):98–105CrossRefPubMed Boydell J et al (2012) Satisfaction with inpatient treatment for first-episode psychosis among different ethnic groups: a report from the UK AESOP study. Int J Soc Psychiatry 58(1):98–105CrossRefPubMed
17.
go back to reference Walkup J et al (2000) Patients with schizophrenia at risk for excessive antipsychotic dosing. J Clin Psychiatry 61:344–348CrossRefPubMed Walkup J et al (2000) Patients with schizophrenia at risk for excessive antipsychotic dosing. J Clin Psychiatry 61:344–348CrossRefPubMed
18.
go back to reference Diaz F, Leon Jd (2002) Excessive antipsychotic dosing in 2 US state hospitals. J Clin Psychiatry 63:998–1003CrossRefPubMed Diaz F, Leon Jd (2002) Excessive antipsychotic dosing in 2 US state hospitals. J Clin Psychiatry 63:998–1003CrossRefPubMed
19.
go back to reference Segal SP, Bola JR, Watson MA (1996) Race, quality of care, and antipsychotic prescribing practices in psychiatric emergency services. Psychiatr serv 47(3):282–286CrossRefPubMed Segal SP, Bola JR, Watson MA (1996) Race, quality of care, and antipsychotic prescribing practices in psychiatric emergency services. Psychiatr serv 47(3):282–286CrossRefPubMed
20.
go back to reference Pinto R et al (2010) Differences in the primary care management of patients with psychosis from two ethnic groups: a population-based cross-sectional study. Fam Pract 27(4):439–446CrossRefPubMed Pinto R et al (2010) Differences in the primary care management of patients with psychosis from two ethnic groups: a population-based cross-sectional study. Fam Pract 27(4):439–446CrossRefPubMed
21.
go back to reference Agyemang C et al (2009) Cardiovascular disease, diabetes and established risk factors among populations of sub-Saharan African descent in Europe: a literature review. Glob Health 5(7):1–17 Agyemang C et al (2009) Cardiovascular disease, diabetes and established risk factors among populations of sub-Saharan African descent in Europe: a literature review. Glob Health 5(7):1–17
25.
go back to reference Leeser R (2011) English indices of deprivation 2010: A London perspective, in Intelligence briefing. Greater London Authority, London Leeser R (2011) English indices of deprivation 2010: A London perspective, in Intelligence briefing. Greater London Authority, London
26.
go back to reference Fekadu A, Medhin G, Kebede D et al (2015) Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia. Br J Psychiatry 206(4):289–296CrossRefPubMed Fekadu A, Medhin G, Kebede D et al (2015) Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia. Br J Psychiatry 206(4):289–296CrossRefPubMed
27.
go back to reference Herrett E et al (2010) Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol 69(1):4–14CrossRefPubMedPubMedCentral Herrett E et al (2010) Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol 69(1):4–14CrossRefPubMedPubMedCentral
28.
go back to reference Schofield P, Chen R, Crichton N (2012) Methods for assessing cardiovascular disease risk in a UK black population. Heart 98(18):1373–1377CrossRefPubMed Schofield P, Chen R, Crichton N (2012) Methods for assessing cardiovascular disease risk in a UK black population. Heart 98(18):1373–1377CrossRefPubMed
29.
go back to reference Schofield P, Ashworth M, Jones R (2011) Ethnic isolation and psychosis: re-examining the ethnic density effect. Psychol Med 41(06):1263–1269CrossRefPubMed Schofield P, Ashworth M, Jones R (2011) Ethnic isolation and psychosis: re-examining the ethnic density effect. Psychol Med 41(06):1263–1269CrossRefPubMed
30.
go back to reference Mathur R, Pollara E, Hull S et al (2013) Ethnicity and stroke risk in patients with atrial fibrillation. Heart 99:1087–1092CrossRefPubMed Mathur R, Pollara E, Hull S et al (2013) Ethnicity and stroke risk in patients with atrial fibrillation. Heart 99:1087–1092CrossRefPubMed
32.
go back to reference Noble M et al (2006) Measuring multiple deprivation at the small-area level. Environ Plan A 38(1):169–185CrossRef Noble M et al (2006) Measuring multiple deprivation at the small-area level. Environ Plan A 38(1):169–185CrossRef
33.
go back to reference World Health Organisation (1978) Mental disorders: glossary and guide to their classification in accordance with the ninth revision of the international classification of diseases. WHO, Geneva World Health Organisation (1978) Mental disorders: glossary and guide to their classification in accordance with the ninth revision of the international classification of diseases. WHO, Geneva
36.
go back to reference (2015) British National Formulary (BNF), vol 70. BMJ Publishing Group Ltd and Royal Pharmaceutical Society of Great Britain (2015) British National Formulary (BNF), vol 70. BMJ Publishing Group Ltd and Royal Pharmaceutical Society of Great Britain
37.
go back to reference Stewart R, Soremekun M, Perera G et al (2009) The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive data. BMC Psychiatry 9(51). doi:10.1186/1471-244X-9-51 Stewart R, Soremekun M, Perera G et al (2009) The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive data. BMC Psychiatry 9(51). doi:10.​1186/​1471-244X-9-51
38.
go back to reference Kadra G et al (2015) Extracting antipsychotic polypharmacy data from electronic health records: developing and evaluating a novel process. BMC Psychiatry 15(1):166CrossRefPubMedPubMedCentral Kadra G et al (2015) Extracting antipsychotic polypharmacy data from electronic health records: developing and evaluating a novel process. BMC Psychiatry 15(1):166CrossRefPubMedPubMedCentral
39.
go back to reference World Health Organisation (1993) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. WHO, Geneva World Health Organisation (1993) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. WHO, Geneva
40.
go back to reference Murdoch TB, Detsky AS (2013) The inevitable application of big data to health care. JAMA 309(13):1351–1352CrossRefPubMed Murdoch TB, Detsky AS (2013) The inevitable application of big data to health care. JAMA 309(13):1351–1352CrossRefPubMed
41.
go back to reference Meystre SM et al (2008) Extracting information from textual documents in the electronic health record: a review of recent research. IMIA Yearbook 2008: access to health. Information 3(1):128–144 Meystre SM et al (2008) Extracting information from textual documents in the electronic health record: a review of recent research. IMIA Yearbook 2008: access to health. Information 3(1):128–144
42.
go back to reference Su Y-P et al (2014) Mini-mental state examination as a predictor of mortality among older people referred to secondary mental healthcare. PLoS One 9(9):e105312CrossRefPubMedPubMedCentral Su Y-P et al (2014) Mini-mental state examination as a predictor of mortality among older people referred to secondary mental healthcare. PLoS One 9(9):e105312CrossRefPubMedPubMedCentral
43.
go back to reference Wu C-Y et al (2013) Evaluation of smoking status identification using electronic health records and open-text information in a large mental health case register. PLoS One 8(9):e74262CrossRefPubMedPubMedCentral Wu C-Y et al (2013) Evaluation of smoking status identification using electronic health records and open-text information in a large mental health case register. PLoS One 8(9):e74262CrossRefPubMedPubMedCentral
44.
go back to reference Patel R et al (2015) Negative symptoms in schizophrenia: a study in a large clinical sample of patients using a novel automated method. BMJ Open 5:e007619CrossRefPubMedPubMedCentral Patel R et al (2015) Negative symptoms in schizophrenia: a study in a large clinical sample of patients using a novel automated method. BMJ Open 5:e007619CrossRefPubMedPubMedCentral
45.
go back to reference Cunningham H et al (2013) Getting more out of biomedical documents with GATE’s full lifecycle open source text analytics. PLoS Comput Biol 9(2):e1002854CrossRefPubMedPubMedCentral Cunningham H et al (2013) Getting more out of biomedical documents with GATE’s full lifecycle open source text analytics. PLoS Comput Biol 9(2):e1002854CrossRefPubMedPubMedCentral
47.
go back to reference Chandola T, Jenkinson C (1999) Social class differences in morbidity using the New UK. National statistics socio-economic classification: do class differences in employment relations explain class differences in health? Ann N Y Acad Sci 896(1):313–315CrossRefPubMed Chandola T, Jenkinson C (1999) Social class differences in morbidity using the New UK. National statistics socio-economic classification: do class differences in employment relations explain class differences in health? Ann N Y Acad Sci 896(1):313–315CrossRefPubMed
48.
49.
go back to reference Carrà G et al (2014) The prevalence of metabolic syndrome in people with severe mental illness: a mediation analysis. Soc Psychiatry Psychiatr Epidemiol 49(11):1739–1746CrossRefPubMed Carrà G et al (2014) The prevalence of metabolic syndrome in people with severe mental illness: a mediation analysis. Soc Psychiatry Psychiatr Epidemiol 49(11):1739–1746CrossRefPubMed
50.
go back to reference Bourque F (2015) A mixed methods study of the relation between migration, ethnicity and psychosis, in Institute of Psychiatry, Psychology and Neuroscience. King’s College London, London Bourque F (2015) A mixed methods study of the relation between migration, ethnicity and psychosis, in Institute of Psychiatry, Psychology and Neuroscience. King’s College London, London
51.
go back to reference Mallett R et al (2002) Social environment, ethnicity and schizophrenia. Soc Psychiatry Psychiatr Epidemiol 37(7):329–335CrossRefPubMed Mallett R et al (2002) Social environment, ethnicity and schizophrenia. Soc Psychiatry Psychiatr Epidemiol 37(7):329–335CrossRefPubMed
52.
go back to reference Braun V, Clarke V (2013) Successful qualitative research. Sage Publications Ltd., London Braun V, Clarke V (2013) Successful qualitative research. Sage Publications Ltd., London
53.
go back to reference NVivo qualitative data analysis Software; QSR International Pty Ltd. Version 10 NVivo qualitative data analysis Software; QSR International Pty Ltd. Version 10
55.
go back to reference Fernandes AC et al (2013) Development and evaluation of a de-identification procedure for a case register sourced from mental health electronic records. BMC Med Inform Decis Mak 13:71CrossRefPubMedPubMedCentral Fernandes AC et al (2013) Development and evaluation of a de-identification procedure for a case register sourced from mental health electronic records. BMC Med Inform Decis Mak 13:71CrossRefPubMedPubMedCentral
56.
go back to reference Mathur R et al (2012) Ethnic differences in primary care management of diabetes and cardiovascular disease in people with serious mental illness. Br J Gen Pract 62(601):e582–e588CrossRefPubMedPubMedCentral Mathur R et al (2012) Ethnic differences in primary care management of diabetes and cardiovascular disease in people with serious mental illness. Br J Gen Pract 62(601):e582–e588CrossRefPubMedPubMedCentral
57.
go back to reference Bhopal R et al (1999) Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study. BMJ 319(7204):215–220CrossRefPubMedPubMedCentral Bhopal R et al (1999) Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study. BMJ 319(7204):215–220CrossRefPubMedPubMedCentral
58.
go back to reference Becker E et al (2006) Health survey for England: 2004. In: Sproston K, Mindell J (eds) The health of minority ethnic groups, in health survey for England. The information centre, Leeds Becker E et al (2006) Health survey for England: 2004. In: Sproston K, Mindell J (eds) The health of minority ethnic groups, in health survey for England. The information centre, Leeds
61.
go back to reference Bhopal RS (2012) Research agenda for tackling inequalities related to migration and ethnicity in Europe. J Public Health 34(2):167–173CrossRef Bhopal RS (2012) Research agenda for tackling inequalities related to migration and ethnicity in Europe. J Public Health 34(2):167–173CrossRef
63.
go back to reference Stuart EA, DuGoff E, Abrams M, Salkever D, Steinwachs D (2013) Estimating causal effects in observational studies using electronic health data: challenges and (some) solutions. eGEMs (Generating Evidence & Methods to improve patient outcomes) 1(3), article 4. doi:10.13063/2327-9214.1038 Stuart EA, DuGoff E, Abrams M, Salkever D, Steinwachs D (2013) Estimating causal effects in observational studies using electronic health data: challenges and (some) solutions. eGEMs (Generating Evidence & Methods to improve patient outcomes) 1(3), article 4. doi:10.​13063/​2327-9214.​1038
64.
go back to reference Welch C, Bartlett J, Petersen I (2014) Application of multiple imputation using the two-fold fully conditional specification algorithm in longitudinal clinical data. Stata J 14(2):418–431PubMedPubMedCentral Welch C, Bartlett J, Petersen I (2014) Application of multiple imputation using the two-fold fully conditional specification algorithm in longitudinal clinical data. Stata J 14(2):418–431PubMedPubMedCentral
Metadata
Title
Ethnicity and cardiovascular health inequalities in people with severe mental illnesses: protocol for the E-CHASM study
Authors
J. Das-Munshi
M. Ashworth
F. Gaughran
S. Hull
C. Morgan
J. Nazroo
A. Roberts
D. Rose
P. Schofield
R. Stewart
G. Thornicroft
M. J. Prince
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 4/2016
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-016-1185-8

Other articles of this Issue 4/2016

Social Psychiatry and Psychiatric Epidemiology 4/2016 Go to the issue