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Published in: Social Psychiatry and Psychiatric Epidemiology 5/2016

01-05-2016 | Review

The Great Smoky Mountains Study: developmental epidemiology in the southeastern United States

Authors: E. Jane Costello, William Copeland, Adrian Angold

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 5/2016

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Abstract

Aims

To describe the Great Smoky Mountains Study (GSMS).

Methods

GSMS is a longitudinal study of child psychiatric disorders that began in 1992 to look at need for mental health services in a rural area of the USA. Over 20 years it has expanded its range to include developmental epidemiology more generally, not only the development of psychiatric and substance abuse problems but also their correlates and predictors: family and environmental risk, physical development including puberty, stress and stress-related hormones, trauma, the impact of poverty, genetic markers, and epigenetics. Now that participants are in their 30s the focus has shifted to adult outcomes of childhood psychopathology and risk, and early physical, cognitive, and psychological markers of aging.

Results

This paper describes the results from over 11,000 interviews, examples of the study’s contributions to science and policy, and plans for the future.

Conclusions

Longitudinal studies can provide insights that aid in policy planning.
Literature
2.
go back to reference Kleinbaum DG, Kupper LL, Morgenstern H (1982) Epidemiologic research: principles and quantitative methods. Van Nostrand Reinhold, New York Kleinbaum DG, Kupper LL, Morgenstern H (1982) Epidemiologic research: principles and quantitative methods. Van Nostrand Reinhold, New York
3.
go back to reference Kellam SG, Werthamer-Larsson L (1986) Developmental epidemiology: a basis for prevention. In: Kessler M, Goldston SE (eds) A decade of progress in primary prevention. University Press of New England, Hanover, NH, pp 154–180 Kellam SG, Werthamer-Larsson L (1986) Developmental epidemiology: a basis for prevention. In: Kessler M, Goldston SE (eds) A decade of progress in primary prevention. University Press of New England, Hanover, NH, pp 154–180
4.
go back to reference Costello EJ, Angold A (2000) Developmental epidemiology: a framework for developmental psychopathology. In: Sameroff A, Lewis M, Miller S (eds) Handbook of developmental psychopathology. Kluwer Academic/Plenum Publishers, New York, pp 57–73CrossRef Costello EJ, Angold A (2000) Developmental epidemiology: a framework for developmental psychopathology. In: Sameroff A, Lewis M, Miller S (eds) Handbook of developmental psychopathology. Kluwer Academic/Plenum Publishers, New York, pp 57–73CrossRef
5.
go back to reference Dohrenwend BP et al (1992) Socioeconomic status and psychiatric disorders: the causation-selection issue. Science 255(Feb. 21):946–952CrossRefPubMed Dohrenwend BP et al (1992) Socioeconomic status and psychiatric disorders: the causation-selection issue. Science 255(Feb. 21):946–952CrossRefPubMed
6.
go back to reference Rutter M, Tizard J, Whitmore K (1970) Education, health, and behaviour. Longman, London Rutter M, Tizard J, Whitmore K (1970) Education, health, and behaviour. Longman, London
7.
go back to reference Bird HR et al (1988) Estimates of the prevalence of childhood maladjustment in a community survey in Puerto Rico: the use of combined measures. Arch Gen Psychiatry 45:1120–1126CrossRefPubMed Bird HR et al (1988) Estimates of the prevalence of childhood maladjustment in a community survey in Puerto Rico: the use of combined measures. Arch Gen Psychiatry 45:1120–1126CrossRefPubMed
8.
go back to reference Achenbach TM, Edelbrock CS (1981) Behavorial problems and competencies reported by parents of normal and disturbed children aged four through sixteen. Monogr Soc Res Child Dev 46:1–82CrossRefPubMed Achenbach TM, Edelbrock CS (1981) Behavorial problems and competencies reported by parents of normal and disturbed children aged four through sixteen. Monogr Soc Res Child Dev 46:1–82CrossRefPubMed
9.
go back to reference Shrout PE, Skodol AE, Dohrenwend BP (1985) A two-stage approach for case identification and diagnosis: First stage instruments. In: Presented at the 75th Annual Meeting of the American Psychopathological Association, New York City. No Journal Found, March 1 Shrout PE, Skodol AE, Dohrenwend BP (1985) A two-stage approach for case identification and diagnosis: First stage instruments. In: Presented at the 75th Annual Meeting of the American Psychopathological Association, New York City. No Journal Found, March 1
10.
go back to reference U.S. Congress and Office of Technology Assessment (1991) Mental health problems: prevention and services, in adolescent health: volume II: background and the effectiveness of selected prevention and treatment services. U.S. Government Printing Office, Washington, DC, p 433–496 U.S. Congress and Office of Technology Assessment (1991) Mental health problems: prevention and services, in adolescent health: volume II: background and the effectiveness of selected prevention and treatment services. U.S. Government Printing Office, Washington, DC, p 433–496
11.
go back to reference Costello AJ et al (1984) Development and testing of the NIMH diagnostic interview schedule for children in a clinic population: final report (contract no. RFP-DB-81-0027). NIMH Center for Epidemiologic Studies, Rockville Costello AJ et al (1984) Development and testing of the NIMH diagnostic interview schedule for children in a clinic population: final report (contract no. RFP-DB-81-0027). NIMH Center for Epidemiologic Studies, Rockville
12.
go back to reference Breton J-J et al (1995) Do children aged 9 to 11 years understand the DISC version 2.25 questions? J Am Acad Child Adolesc Psychiatry 34:946–956CrossRefPubMed Breton J-J et al (1995) Do children aged 9 to 11 years understand the DISC version 2.25 questions? J Am Acad Child Adolesc Psychiatry 34:946–956CrossRefPubMed
14.
go back to reference Rutter M (2013) Developmental psychopathology: a paradigm shift or just a relabeling? Dev Psychopathol 25(4pt2):1201CrossRefPubMed Rutter M (2013) Developmental psychopathology: a paradigm shift or just a relabeling? Dev Psychopathol 25(4pt2):1201CrossRefPubMed
15.
go back to reference Wing JK, Cooper JE, Sartorius N (eds) (1974) The measurement and classification of psychiatric symptoms: an instruction manual for the present state examination and CATEGO programme. Cambridge University Press, Cambridge Wing JK, Cooper JE, Sartorius N (eds) (1974) The measurement and classification of psychiatric symptoms: an instruction manual for the present state examination and CATEGO programme. Cambridge University Press, Cambridge
16.
go back to reference Robins LN et al (1981) National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics, and validity. Arch Gen Psychiatry 38:381–389CrossRefPubMed Robins LN et al (1981) National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics, and validity. Arch Gen Psychiatry 38:381–389CrossRefPubMed
17.
go back to reference Angold A (2002) Diagnostic interviews with parents and children. In: Rutter M, Taylor E (eds) Child and adolescent psychiatry: modern approaches. Blackwell Scientific Publications, Oxford, pp 32–51 Angold A (2002) Diagnostic interviews with parents and children. In: Rutter M, Taylor E (eds) Child and adolescent psychiatry: modern approaches. Blackwell Scientific Publications, Oxford, pp 32–51
18.
go back to reference Egger HL, Angold A (2004) The preschool age psychiatric assessment (PAPA): a structured parent interview for diagnosing psychiatric disorders in preschool children. In: DelCarmen-Wiggins R, Carter A (eds) Handbook of infant, toddler, and preschool mental assessment. Oxford University Press, New York, pp 223–243 Egger HL, Angold A (2004) The preschool age psychiatric assessment (PAPA): a structured parent interview for diagnosing psychiatric disorders in preschool children. In: DelCarmen-Wiggins R, Carter A (eds) Handbook of infant, toddler, and preschool mental assessment. Oxford University Press, New York, pp 223–243
19.
go back to reference Angold A, Cox A, Prendergast M, Rutter M, Simonoff E, Costello E, Ascher B (1999) The young adult psychiatric assessment (YAPA). Duke University Medical Center, Durham (Unpublished) Angold A, Cox A, Prendergast M, Rutter M, Simonoff E, Costello E, Ascher B (1999) The young adult psychiatric assessment (YAPA). Duke University Medical Center, Durham (Unpublished)
20.
go back to reference Angold A, Cox A, Prendergast M, Rutter M, Simonoff E (1995) Glossary for the child and adoelscent assessment. Duke University Medical Center, Durham (Unpublished) Angold A, Cox A, Prendergast M, Rutter M, Simonoff E (1995) Glossary for the child and adoelscent assessment. Duke University Medical Center, Durham (Unpublished)
21.
go back to reference Farmer EMZ et al (1994) Reliability of self-reported service use: test–retest consistency of children’s responses to the Child and Adolescent Services Assessment (CASA). J Child Fam Stud 3(3):307–325CrossRef Farmer EMZ et al (1994) Reliability of self-reported service use: test–retest consistency of children’s responses to the Child and Adolescent Services Assessment (CASA). J Child Fam Stud 3(3):307–325CrossRef
22.
go back to reference Costello EJ et al (1998) Life events and post-traumatic stress: the development of a new measure for children and adolescents. Psychol Med 28:1275–1288CrossRefPubMed Costello EJ et al (1998) Life events and post-traumatic stress: the development of a new measure for children and adolescents. Psychol Med 28:1275–1288CrossRefPubMed
23.
24.
go back to reference McDade TW, Williams S, Snodgrass JJ (2007) What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research. Demography 44(4):899–925CrossRefPubMed McDade TW, Williams S, Snodgrass JJ (2007) What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research. Demography 44(4):899–925CrossRefPubMed
25.
go back to reference McDade T, Angold A, Costello EJ, Stallings JF, Worthman CM (1995) Physiologic bases of individual variation in pubertal timing and progression: report from the great smoky mountains study. Am J Phys Anthropol Suppl. 20:148 McDade T, Angold A, Costello EJ, Stallings JF, Worthman CM (1995) Physiologic bases of individual variation in pubertal timing and progression: report from the great smoky mountains study. Am J Phys Anthropol Suppl. 20:148
26.
go back to reference Worthman CM, Stallings JF (1994) Measurement of gonadotropins in dried blood spots. Clin Chem 40:448–453PubMed Worthman CM, Stallings JF (1994) Measurement of gonadotropins in dried blood spots. Clin Chem 40:448–453PubMed
28.
go back to reference Costello EJ, Eaves L, Sullivan P, Kennedy M, Conway K, Adkins DE, Angold A, Clark SL, Erkanli A, McClay JL (2013) Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. Twin Res Hum Genet 16:505–515CrossRefPubMedPubMedCentral Costello EJ, Eaves L, Sullivan P, Kennedy M, Conway K, Adkins DE, Angold A, Clark SL, Erkanli A, McClay JL (2013) Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. Twin Res Hum Genet 16:505–515CrossRefPubMedPubMedCentral
29.
go back to reference Dorn LD et al (1990) Perceptions of puberty: adolescent, parent, and health care personnel. Dev Psychopathol 26(2):322–329CrossRef Dorn LD et al (1990) Perceptions of puberty: adolescent, parent, and health care personnel. Dev Psychopathol 26(2):322–329CrossRef
30.
go back to reference Petersen AC (1985) Pubertal development as a cause of disturbance: myths, realities, and unanswered questions. Genet Soc Gen Psychol Monogr 111(2):205–232PubMed Petersen AC (1985) Pubertal development as a cause of disturbance: myths, realities, and unanswered questions. Genet Soc Gen Psychol Monogr 111(2):205–232PubMed
31.
go back to reference U.S. Public Health Service (1988) National Health Interview Survey: supplement booklet. U.S. Department of Commerce Bureau of the Census, Washington, DC U.S. Public Health Service (1988) National Health Interview Survey: supplement booklet. U.S. Department of Commerce Bureau of the Census, Washington, DC
32.
go back to reference Angold A, Costello EJ (2006) Puberty and depression. Child Adolesc Psychiatr Clin N Am 15:919–937CrossRefPubMed Angold A, Costello EJ (2006) Puberty and depression. Child Adolesc Psychiatr Clin N Am 15:919–937CrossRefPubMed
33.
go back to reference Tanner JM (1962) Growth at adolescence: with a general consideration of the effects of hereditary and environmental factors upon growth and maturation from birth to maturity. Vol. Second Edition, Fifth Printing. Blackwell Scientific Publications, Oxford Tanner JM (1962) Growth at adolescence: with a general consideration of the effects of hereditary and environmental factors upon growth and maturation from birth to maturity. Vol. Second Edition, Fifth Printing. Blackwell Scientific Publications, Oxford
34.
go back to reference Worthman CM, Stallings JF (1997) Hormone measures in finger-prick blood spot samples: new field methods for reproductive endocrinology. Am J Phys Anthropol 103(1):1–21CrossRef Worthman CM, Stallings JF (1997) Hormone measures in finger-prick blood spot samples: new field methods for reproductive endocrinology. Am J Phys Anthropol 103(1):1–21CrossRef
35.
go back to reference Angold A, Costello EJ, Worthman CM (1998) Puberty and depression: the roles of age, pubertal status, and pubertal timing. Psychol Med 28:51–61CrossRefPubMed Angold A, Costello EJ, Worthman CM (1998) Puberty and depression: the roles of age, pubertal status, and pubertal timing. Psychol Med 28:51–61CrossRefPubMed
36.
go back to reference Costello EJ et al (2007) Prediction from low birth weight to female adolescent depression: a test of competing hypotheses. Arch Gen Psychiatry 64:338–344CrossRefPubMed Costello EJ et al (2007) Prediction from low birth weight to female adolescent depression: a test of competing hypotheses. Arch Gen Psychiatry 64:338–344CrossRefPubMed
37.
go back to reference Costello EJ et al (2003) Relationships between poverty and psychopathology: a natural experiment. JAMA 290(15):2023–2029CrossRefPubMed Costello EJ et al (2003) Relationships between poverty and psychopathology: a natural experiment. JAMA 290(15):2023–2029CrossRefPubMed
38.
go back to reference Costello EJ (2010) Family income supplements and development of psychiatric and substance use disorders among an american indian population—reply. JAMA J Am Med Assoc 304(9):963CrossRef Costello EJ (2010) Family income supplements and development of psychiatric and substance use disorders among an american indian population—reply. JAMA J Am Med Assoc 304(9):963CrossRef
39.
go back to reference Huang B et al (2004) Statistical assessment of mediational effects for logistic mediational models. Stat Med 23:2713–2728CrossRefPubMed Huang B et al (2004) Statistical assessment of mediational effects for logistic mediational models. Stat Med 23:2713–2728CrossRefPubMed
40.
go back to reference Baron RM, Kenny DA (1986) The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173–1182CrossRefPubMed Baron RM, Kenny DA (1986) The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173–1182CrossRefPubMed
41.
go back to reference Kim-Cohen J et al (2003) Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Arch Gen Psychiatry 60:709–717CrossRefPubMed Kim-Cohen J et al (2003) Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Arch Gen Psychiatry 60:709–717CrossRefPubMed
42.
go back to reference Copeland W et al (2011) Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the great smoky mountains study. J Am Acad Child Adolesc Psychiatry 50(3):252–261CrossRefPubMedPubMedCentral Copeland W et al (2011) Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the great smoky mountains study. J Am Acad Child Adolesc Psychiatry 50(3):252–261CrossRefPubMedPubMedCentral
43.
go back to reference Kessler RC et al (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62(6):593–602CrossRefPubMed Kessler RC et al (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62(6):593–602CrossRefPubMed
44.
45.
go back to reference Lewinsohn PM et al (2004) The prevalence of comorbidity of subthreshold psychiatric conditions. Psychol Med 34:613–622CrossRefPubMed Lewinsohn PM et al (2004) The prevalence of comorbidity of subthreshold psychiatric conditions. Psychol Med 34:613–622CrossRefPubMed
46.
go back to reference Herrenkohl EC et al (1995) Risk factors for behavioral dysfunction: the relative impact of maltreatment, SES, physical health problems, cognitive ability, and quality of parent-child interaction. Child Abuse Negl 19(2):191–203CrossRefPubMed Herrenkohl EC et al (1995) Risk factors for behavioral dysfunction: the relative impact of maltreatment, SES, physical health problems, cognitive ability, and quality of parent-child interaction. Child Abuse Negl 19(2):191–203CrossRefPubMed
47.
go back to reference Harhay MO, King CH (2012) Global burden of disease in young people aged 10–24 years. Lancet 379(9810):27–28CrossRefPubMed Harhay MO, King CH (2012) Global burden of disease in young people aged 10–24 years. Lancet 379(9810):27–28CrossRefPubMed
Metadata
Title
The Great Smoky Mountains Study: developmental epidemiology in the southeastern United States
Authors
E. Jane Costello
William Copeland
Adrian Angold
Publication date
01-05-2016
Publisher
Springer Berlin Heidelberg
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 5/2016
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-015-1168-1

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