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Published in: Social Psychiatry and Psychiatric Epidemiology 7/2007

01-07-2007 | ORIGINAL PAPER

Psychosis and adults with intellectual disabilities

Prevalence, incidence, and related factors

Authors: Sally-Ann Cooper, Elita Smiley, Jillian Morrison, Linda Allan, Andrew Williamson, Janet Finlayson, Alison Jackson, Dipali Mantry

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 7/2007

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Abstract

Objective

To determine the point prevalence, incidence, and remission over a 2-year period of psychosis in adults with intellectual disabilities, and to investigate demographic and clinical factors hypothesised to be associated with psychosis.

Method

A population-based cohort of adults with intellectual disabilities (n = 1,023) was longitudinally studied. Comprehensive face-to-face mental health assessments to detect psychosis, plus review of family physician, psychiatric, and psychology case notes were undertaken at two time points, 2 years apart.

Results

Point prevalence is 2.6% (95% CI = 1.8–3.8%) to 4.4% (95% CI = 3.2–5.8%), dependant upon the diagnostic criteria employed. Two-year incidence is 1.4% (95% CI = 0.6–2.6), and for first episode is 0.5% (95% CI = 0.1–1.3). Compared with the general population, the standardised incidence ratio for first episode psychosis is 10.0 (95% CI = 2.1–29.3). Full remission after 2 years is 14.3%. Visual impairment, previous long-stay hospital residence, smoking, and not having epilepsy were independently associated with psychosis, whereas other factors relevant to the general population were not.

Conclusions

The study of psychosis in persons with intellectual disabilities benefits the population with intellectual disabilities, and advances the understanding of psychosis for the general population. Mental health professionals need adequate knowledge in order to address the high rates of psychosis in this population.
Literature
1.
go back to reference American Psychiatric Association (1980) Diagnostic, statistical manual of mental disorders, 3rd edn. A.P.A.,Washington DC American Psychiatric Association (1980) Diagnostic, statistical manual of mental disorders, 3rd edn. A.P.A.,Washington DC
2.
go back to reference American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. (revised). A.P.A., Washington, DC American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. (revised). A.P.A., Washington, DC
3.
go back to reference Beardsmore A, Dorman T, Cooper S-A, Webb T (1998) Affective psychosis and Prader-Willi syndrome. J Intellect Disabil Res 42:463–471PubMedCrossRef Beardsmore A, Dorman T, Cooper S-A, Webb T (1998) Affective psychosis and Prader-Willi syndrome. J Intellect Disabil Res 42:463–471PubMedCrossRef
4.
go back to reference Boer H, Holland A, Whittington J, Butler J, Webb T, Clark D (2002) Psychotic illness in people with Prader Willi syndrome due to chromosome 15 maternal uniparental disomy. Lancet 359:135PubMedCrossRef Boer H, Holland A, Whittington J, Butler J, Webb T, Clark D (2002) Psychotic illness in people with Prader Willi syndrome due to chromosome 15 maternal uniparental disomy. Lancet 359:135PubMedCrossRef
5.
go back to reference Boydell J, van Os J, McKenzie K, Murray RM (2004) The association of inequality with the incidence of schizophrenia – an ecological study. Soc Psychiatry Psychiatr Epidemiol 39:597–599PubMedCrossRef Boydell J, van Os J, McKenzie K, Murray RM (2004) The association of inequality with the incidence of schizophrenia – an ecological study. Soc Psychiatry Psychiatr Epidemiol 39:597–599PubMedCrossRef
6.
go back to reference Bredkjær SR, Mortensen PB, Parnas J (1998) Epilepsy and non-organic non-affective psychosis. National epidemiological study. Br J Psychiatry 172:235–238PubMed Bredkjær SR, Mortensen PB, Parnas J (1998) Epilepsy and non-organic non-affective psychosis. National epidemiological study. Br J Psychiatry 172:235–238PubMed
7.
go back to reference Brugha T, Singleton N, Meltzer H, Bebbington P, Farrell M, Jenkins R, Coid J, Fryers T, Melzer D, Lewis G (2005) Psychosis in the community and in prisons: a report from the British National Survey of psychiatric morbidity. Am J Psychiatry 162:774–780PubMedCrossRef Brugha T, Singleton N, Meltzer H, Bebbington P, Farrell M, Jenkins R, Coid J, Fryers T, Melzer D, Lewis G (2005) Psychosis in the community and in prisons: a report from the British National Survey of psychiatric morbidity. Am J Psychiatry 162:774–780PubMedCrossRef
8.
go back to reference Cooper S-A (1997) Epidemiology of psychiatric disorders in elderly compared with younger adults with learning disabilities. Br J Psychiatry 170:375–380PubMed Cooper S-A (1997) Epidemiology of psychiatric disorders in elderly compared with younger adults with learning disabilities. Br J Psychiatry 170:375–380PubMed
9.
go back to reference Cooper S-A, Bailey N (2001) Psychiatric disorders amongst adults with learning disabilities: prevalence and relationship to ability level. Psychol Med 18:45–53 Cooper S-A, Bailey N (2001) Psychiatric disorders amongst adults with learning disabilities: prevalence and relationship to ability level. Psychol Med 18:45–53
10.
go back to reference Corbett JA (1979) Psychiatric morbidity and mental retardation. In: James FE, Snaith RP (eds) Psychiatric illness and mental handicap. Gaskell, London, pp 11–25 Corbett JA (1979) Psychiatric morbidity and mental retardation. In: James FE, Snaith RP (eds) Psychiatric illness and mental handicap. Gaskell, London, pp 11–25
11.
go back to reference Curtice L, Cooper S-A, Espie CA, Morrison J, Ibbotson T, Long L, Allan L (2001) Implementing partnership for health: piloting health checks for people with learning disabilities in Glasgow – final report. Greater Glasgow Primary Care NHS Trust R&D Directorate, Glasgow, Scotland Curtice L, Cooper S-A, Espie CA, Morrison J, Ibbotson T, Long L, Allan L (2001) Implementing partnership for health: piloting health checks for people with learning disabilities in Glasgow – final report. Greater Glasgow Primary Care NHS Trust R&D Directorate, Glasgow, Scotland
12.
go back to reference Deb S, Thomas M, Bright C (2001) Mental disorder in adults with intellectual disability I: Prevalence of functional psychiatric disorder among a community-based population aged between 16 and 64 years. J Intellect Disabil Res 45:495–505PubMedCrossRef Deb S, Thomas M, Bright C (2001) Mental disorder in adults with intellectual disability I: Prevalence of functional psychiatric disorder among a community-based population aged between 16 and 64 years. J Intellect Disabil Res 45:495–505PubMedCrossRef
13.
go back to reference Doody GA, Johnstone EC, Sanderson TL, Owens DG, Muir WJ (1998) Propfschizophrenie revisited. Schizophrenia in people with mild learning disability. Br J Psychiatry 173:145–153PubMedCrossRef Doody GA, Johnstone EC, Sanderson TL, Owens DG, Muir WJ (1998) Propfschizophrenie revisited. Schizophrenia in people with mild learning disability. Br J Psychiatry 173:145–153PubMedCrossRef
14.
go back to reference Farmer R, Rohde J, Sacks B (1993) Changing services for people with learning disabilities. Chapman and Hall, London, pp 17–30 Farmer R, Rohde J, Sacks B (1993) Changing services for people with learning disabilities. Chapman and Hall, London, pp 17–30
15.
go back to reference Glasgow CEDD (2001) The C21st Health Check. University of Glasgow, Glasgow, Scotland Glasgow CEDD (2001) The C21st Health Check. University of Glasgow, Glasgow, Scotland
16.
go back to reference Hemmings CP (2006) Schizophrenia spectrum disorders in people with intellectual disabilities. Curr Opin Psychiatry 19:470–474PubMedCrossRef Hemmings CP (2006) Schizophrenia spectrum disorders in people with intellectual disabilities. Curr Opin Psychiatry 19:470–474PubMedCrossRef
17.
go back to reference Jenkins R, Lewis G, Bebbington P, Brugha T, Farrell M, Gill B, Meltzer H (1997) The national psychiatric morbidity survey of Great Britain – initial findings from the household survey. Psychol Med 77:775–789CrossRef Jenkins R, Lewis G, Bebbington P, Brugha T, Farrell M, Gill B, Meltzer H (1997) The national psychiatric morbidity survey of Great Britain – initial findings from the household survey. Psychol Med 77:775–789CrossRef
18.
go back to reference Johns LC, Cannon M, Singleton N, Murray RM, Farrell M, Brugha T, Bebbington P, Jenkins R, Meltzer H (2004) Prevalence and correlates of self-reported psychotic symptoms in the British population. Br J Psychiatry 185:298–305PubMedCrossRef Johns LC, Cannon M, Singleton N, Murray RM, Farrell M, Brugha T, Bebbington P, Jenkins R, Meltzer H (2004) Prevalence and correlates of self-reported psychotic symptoms in the British population. Br J Psychiatry 185:298–305PubMedCrossRef
19.
go back to reference Kelly C, McCreadie R (1999) Smoking habits, current symptoms, and premorbid characteristics of schizophrenic patients in Nithsdale, Scotland. Am J Psychiatry 156:1751–1757PubMed Kelly C, McCreadie R (1999) Smoking habits, current symptoms, and premorbid characteristics of schizophrenic patients in Nithsdale, Scotland. Am J Psychiatry 156:1751–1757PubMed
20.
go back to reference Kerker BD, Owens PL, Zigler PI, Horwitz SM (2004) Mental health disorders among individuals with mental retardation: challenges to accurate prevalence estimates. Public Health Rep 119:409–417PubMedCrossRef Kerker BD, Owens PL, Zigler PI, Horwitz SM (2004) Mental health disorders among individuals with mental retardation: challenges to accurate prevalence estimates. Public Health Rep 119:409–417PubMedCrossRef
21.
go back to reference Kirkbride JB, Fearon P, Morgan C, Dazzan P, Morgan K, Tarrant J, Lloyd T, Holloway J, Hutchinson G, Leff J, Mallett RM, Harrison GL, Murray RM, Jones PB (2006) Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes. Arch Gen Psychiatry 63:250–258PubMedCrossRef Kirkbride JB, Fearon P, Morgan C, Dazzan P, Morgan K, Tarrant J, Lloyd T, Holloway J, Hutchinson G, Leff J, Mallett RM, Harrison GL, Murray RM, Jones PB (2006) Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes. Arch Gen Psychiatry 63:250–258PubMedCrossRef
22.
go back to reference Leonard H, Wen X (2002) The epidemiology of mental retardation: challenges and opportunities in the new millennium. Mental Retard Dev Disabil Res Rev 8:117–134CrossRef Leonard H, Wen X (2002) The epidemiology of mental retardation: challenges and opportunities in the new millennium. Mental Retard Dev Disabil Res Rev 8:117–134CrossRef
23.
go back to reference Leonard H, Petterson B, Bower C (2002) Prevalence of intellectual disability in Western Australia. Paediatr Perinat Epidemiol Leonard H, Petterson B, Bower C (2002) Prevalence of intellectual disability in Western Australia. Paediatr Perinat Epidemiol
24.
go back to reference Lund J (1985) The prevalence of psychiatric disorder in mentally retarded adults. Acta Psychiatr Scand 72:563–570PubMed Lund J (1985) The prevalence of psychiatric disorder in mentally retarded adults. Acta Psychiatr Scand 72:563–570PubMed
25.
go back to reference Maughan B, Collishaw S, Pickles A (1999) Mild mental retardation: psychosocial functioning in adulthood. Psychol Med 29:351–366PubMedCrossRef Maughan B, Collishaw S, Pickles A (1999) Mild mental retardation: psychosocial functioning in adulthood. Psychol Med 29:351–366PubMedCrossRef
26.
go back to reference McGrother C, Thorp C, Taub N, Machado O (2001) Prevalence, disability and need in adults with severe learning disability. Tizard Learn Disabil Rev 6:4–13 McGrother C, Thorp C, Taub N, Machado O (2001) Prevalence, disability and need in adults with severe learning disability. Tizard Learn Disabil Rev 6:4–13
27.
go back to reference McLaren GL, Bain MRS (1998) Deprivation and health in Scotland: insights from NHS data. ISD Scotland Publications, Edinburgh McLaren GL, Bain MRS (1998) Deprivation and health in Scotland: insights from NHS data. ISD Scotland Publications, Edinburgh
28.
go back to reference Moss S, Prosser H, Costello H, Simpson N, Patel P, Rowe S, Turner S, Hatton C (1998) Reliability and validity of the PAS-ADD Checklist for detecting psychiatric disorders in adults with intellectual disability. J Intellect Disabil Res 42:173–183PubMedCrossRef Moss S, Prosser H, Costello H, Simpson N, Patel P, Rowe S, Turner S, Hatton C (1998) Reliability and validity of the PAS-ADD Checklist for detecting psychiatric disorders in adults with intellectual disability. J Intellect Disabil Res 42:173–183PubMedCrossRef
29.
go back to reference Murphy KC, Owen MJ (2001) Velo-cardio-facial syndrome: a model for understanding the genetics and pathogenesis of schizophrenia. Br J Psychiatry 179:397–402PubMedCrossRef Murphy KC, Owen MJ (2001) Velo-cardio-facial syndrome: a model for understanding the genetics and pathogenesis of schizophrenia. Br J Psychiatry 179:397–402PubMedCrossRef
30.
go back to reference O’Dwyer JM (1997) Schizophrenia in people with intellectual disability: the role of pregnancy and birth complications. J Intellect Disabil Res 41:238–251PubMedCrossRef O’Dwyer JM (1997) Schizophrenia in people with intellectual disability: the role of pregnancy and birth complications. J Intellect Disabil Res 41:238–251PubMedCrossRef
31.
go back to reference Reiss S (1993) Handbook of challenging behaviour; Mental health aspects of mental retardation. IDS Publishing Corporation, Worthington, Ohio, pp 6–10 Reiss S (1993) Handbook of challenging behaviour; Mental health aspects of mental retardation. IDS Publishing Corporation, Worthington, Ohio, pp 6–10
32.
go back to reference Richards M, Maugan B, Hardy R, Hall I, Srydom A, Wadsworth M (2001) Long-term affective disorder in people with learning disability. Br J Psychiatry 170:523–527CrossRef Richards M, Maugan B, Hardy R, Hall I, Srydom A, Wadsworth M (2001) Long-term affective disorder in people with learning disability. Br J Psychiatry 170:523–527CrossRef
33.
go back to reference Royal College of Psychiatrists (2001) DC-LD [Diagnostic criteria for psychiatric disorders for use with adults with learning disabilities/mental retardation]. Gaskell Press, London Royal College of Psychiatrists (2001) DC-LD [Diagnostic criteria for psychiatric disorders for use with adults with learning disabilities/mental retardation]. Gaskell Press, London
34.
go back to reference Sanderson TL, Doody GA, Best J, Owens DG, Johnstone EC (2001) Correlations between clinical and historical variables, and cerebral structural variables in people with mild intellectual disability and schizophrenia. J Intellect Disabil Res 45:89–98PubMedCrossRef Sanderson TL, Doody GA, Best J, Owens DG, Johnstone EC (2001) Correlations between clinical and historical variables, and cerebral structural variables in people with mild intellectual disability and schizophrenia. J Intellect Disabil Res 45:89–98PubMedCrossRef
35.
go back to reference Schurbert EW, Henriksson KM, McNeil TF (2005) A prospective study of offspring of women with psychosis: visual dysfunction in early childhood predicts schizophrenia spectrum disorder in adulthood. Acta Psychiatr Scand 112:385–393CrossRef Schurbert EW, Henriksson KM, McNeil TF (2005) A prospective study of offspring of women with psychosis: visual dysfunction in early childhood predicts schizophrenia spectrum disorder in adulthood. Acta Psychiatr Scand 112:385–393CrossRef
36.
go back to reference Simpson NJ (1999) Psychiatric disorders in people with learning disabilities: measuring prevalence and validating a screening instrument. Thesis/Dissertation, University of Manchester, pp 160–161 Simpson NJ (1999) Psychiatric disorders in people with learning disabilities: measuring prevalence and validating a screening instrument. Thesis/Dissertation, University of Manchester, pp 160–161
37.
go back to reference Smiley E (2005) Epidemiology of mental health problems in adults with learning disabilities: an update. Adv Psychiatr Treat 11:214–222CrossRef Smiley E (2005) Epidemiology of mental health problems in adults with learning disabilities: an update. Adv Psychiatr Treat 11:214–222CrossRef
38.
go back to reference Sparrow SS, Balla DA, Cicchetti DV (1984) A revision of the Vineland social maturity scale by E A Doll. American Guidance Service, Inc., Minnesota Sparrow SS, Balla DA, Cicchetti DV (1984) A revision of the Vineland social maturity scale by E A Doll. American Guidance Service, Inc., Minnesota
39.
go back to reference Sturmey P, Newton JT, Cowley A, Bouras N, Holt G (2005) The PAS-ADD Checklist: independent replication of its psychometric properties in a community sample. Br J Psychiatr 186:319–323CrossRef Sturmey P, Newton JT, Cowley A, Bouras N, Holt G (2005) The PAS-ADD Checklist: independent replication of its psychometric properties in a community sample. Br J Psychiatr 186:319–323CrossRef
40.
go back to reference Turner TH (1989) Schizophrenia and mental handicap: an historical review, with implications for further research. Psychol Med 19:301–314PubMedCrossRef Turner TH (1989) Schizophrenia and mental handicap: an historical review, with implications for further research. Psychol Med 19:301–314PubMedCrossRef
41.
go back to reference Van Schrojenstein Lantman de-Valk HMJ, Wullink M, van den Akker M, van Heurn-Nijsten EWA, Metsemakers JFM, Dinant GJ (2006) The prevalence of intellectual disability in Limburg, the Netherlands. J Intellect Disabil Res 50:61–68 Van Schrojenstein Lantman de-Valk HMJ, Wullink M, van den Akker M, van Heurn-Nijsten EWA, Metsemakers JFM, Dinant GJ (2006) The prevalence of intellectual disability in Limburg, the Netherlands. J Intellect Disabil Res 50:61–68
42.
go back to reference Wadsworth MEJ, Mann SL, Rodgers B, Kuh DJL, Hilder WS, Yusuf EJ (1992) Loss and representativeness in a 43 year follow up of a national birth cohort. J Epidemiol Community Health 46:300–304PubMed Wadsworth MEJ, Mann SL, Rodgers B, Kuh DJL, Hilder WS, Yusuf EJ (1992) Loss and representativeness in a 43 year follow up of a national birth cohort. J Epidemiol Community Health 46:300–304PubMed
43.
go back to reference World Health Organisation (1968) Eighth revision of the international classification of diseases: glossary of psychiatric disorders. W.H.O., Geneva World Health Organisation (1968) Eighth revision of the international classification of diseases: glossary of psychiatric disorders. W.H.O., Geneva
44.
go back to reference World Health Organization (1992) Schedules for clinical assessment in neuropsychiatry. World Health Organization, Geneva World Health Organization (1992) Schedules for clinical assessment in neuropsychiatry. World Health Organization, Geneva
45.
go back to reference World Health Organisation (1993) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. WHO, Geneva World Health Organisation (1993) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. WHO, Geneva
Metadata
Title
Psychosis and adults with intellectual disabilities
Prevalence, incidence, and related factors
Authors
Sally-Ann Cooper
Elita Smiley
Jillian Morrison
Linda Allan
Andrew Williamson
Janet Finlayson
Alison Jackson
Dipali Mantry
Publication date
01-07-2007
Publisher
D. Steinkopff-Verlag
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 7/2007
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-007-0197-9

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