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European Journal of Trauma and Emergency Surgery

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01-02-2022 | Bisoprolol | Original Article

β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury

Authors: Mengyang Yu, Qi Lv, Jie Shi, Yahua Liu, Haojun Fan, Hui Ding, Ziquan Liu, Juan Cao, Yanhua Gong, Shike Hou

Published in: European Journal of Trauma and Emergency Surgery | Issue 1/2022

Abstract

Background

Crush injury/crush syndrome (CI/CS) is the second most common cause of death during earthquakes. Most studies of CI/CS have mainly focused on kidney injury after decompression. Few studies have focused on myocardial injury caused by crush injury and its potential mechanisms.

Methods

We first verified cardiomyocyte injury during compression in rats with a crush injury. The survival rate, electrocardiographic results, histological results, catecholamine changes and cardiac β1-AR expression were evaluated. Next, we explored the effects of pretreatment with a selective β1-blocker (bisoprolol) with or without fluid resuscitation on rats with a crush injury. In addition to evaluating the survival rates, biochemical and histological analyses and echocardiographic measurements were also performed.

Results

Reduced heart rates, elevated ST segments, and tall-peaked T waves were observed in the rats with a crush injury. The changes in the myocardial enzymes and pathological results demonstrated that myocardial damage occurred during compression in rats with a crush injury. The levels of the catecholamine norepinephrine in both the serum and myocardial tissue were elevated during compression. Pretreatment with a selective β1-blocker combined with fluid resuscitation significantly improved the survival rates of the rats with lethal crush injury. The myocardial enzymes and pathological results showed that the combined therapy decreased myocardial damage. The echocardiography measurements showed that the rats that received the combined therapy exhibited decreased left ventricular mass (LVM), left ventricular volume at end-systole (LVVs) and left ventricular internal diameter (LVID) compared with the rats with a crush injury.

Conclusions

Our findings demonstrated the presence of myocardial injury in the early stage of compression in rats with a crush injury. Pretreatment with a β1-blocker (bisoprolol) with fluid resuscitation significantly reduced mortality, decreased myocardial tissue damage, and improved ventricular remodelling in rats with a lethal crush injury.

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Title: β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury
Authors: Mengyang Yu
Qi Lv
Jie Shi
Yahua Liu
Haojun Fan
Hui Ding
Ziquan Liu
Juan Cao
Yanhua Gong
Shike Hou
Publication date: 01-02-2022
Publisher: Springer Berlin Heidelberg
Keyword: Bisoprolol
Published in: European Journal of Trauma and Emergency Surgery / Issue 1/2022
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI: https://doi.org/10.1007/s00068-020-01408-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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